ocr: Summary and Review Tools Mechanism Review: Substitution versus Elimination SN2 SN1 and E1 Primary substrate Tertiary substrate Back-side attack of Nu: with respect to LG Carbocation intermediate Strong/polarizable unhindered nucleophile Weak nucleophile/base (e.g., solvent) Favored Inversion Concerted Bimolecular by of bond in polar stereochemistry aprotic forming/bond rate-determining solvent step breaking Protic Removal Racemization Unimolecular solvent of if in B-hydrogen assists SNl if rate-determining ionization E1 of LG step Low temperature (SN1)/high temperature (E2) Nu/B8- LGS Nu:/B: V ...
