home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
CD-ROM Today (UK) (Spanish) 15
/
CDRT.iso
/
dp
/
0422
/
04222.txt
< prev
next >
Wrap
Text File
|
1994-01-17
|
5KB
|
139 lines
$Unique_ID{BRK04222}
$Pretitle{}
$Title{Simian B Virus Infection}
$Subject{Simian B Virus Infection Herpesvirus Simiae, B Virus H Simiae
Encephalomyelitis Monkey B Virus Acute Disseminated Encephalomyelitis}
$Volume{}
$Log{}
Copyright (C) 1987, 1989 National Organization for Rare Disorders, Inc.
487:
Simian B Virus Infection
** IMPORTANT **
It is possible the main title of the article (Simian B Virus) is not the
name you expected. Please check the SYNONYMS listing on the next page to
find alternate names, disorder subdivisions, and related disorders covered by
this article.
Synonyms
Herpesvirus Simiae, B Virus
H Simiae Encephalomyelitis
Monkey B Virus
Information on the following diseases can be found in the Related
Disorders section of this report:
Acute Disseminated Encephalomyelitis
General Discussion
** REMINDER **
The information contained in the Rare Disease Database is provided for
educational purposes only. It should not be used for diagnostic or treatment
purposes. If you wish to obtain more information about this disorder, please
contact your personal physician and/or the agencies listed in the "Resources"
section of this report.
Simian B Virus Infection is caused by a type of herpesvirus. It is an
infectious disorder contracted chiefly by laboratory workers exposed to
infected monkeys and/or simian tissue cultures. It is characterized by a
viral invasion of the brain (Encephalitis) and the membranes (meninges)
surrounding the brain. Occasionally, the infection affects the spinal cord
structures as well (Encephalomyelitis). Neurological damage may result from
this infection. Without treatment, some cases of Simian B Virus may be life-
threatening.
Symptoms
Simian B Virus Infection is characterized by fever, headache, vomiting,
discomfort (malaise), and a stiff neck and back. These symptoms may be
associated with neuromuscular dysfunction, respiratory difficulties, vision
problems, cranial nerve abnormalities, alteration of consciousness,
personality changes, seizures and/or partial paralysis (paresis). Some
patients may go into a coma.
Causes
Simian B Virus Infection is caused by exposure to infected monkeys and/or
simian tissue cultures of the virus, usually in laboratory settings.
Affected Population
Simian B Virus Infection usually affects laboratory workers bitten or
scratched by infected monkeys, or those exposed to virus infected simian
tissue cultures. According to one study, an estimated twenty-four cases of
the disorder occurred between 1932 and 1972 in the United States.
Related Disorders
Symptoms of the following disorders can be similar to those of Simian B
Virus. Comparisons may be useful for a differential diagnosis:
Acute Disseminated Encephalomyelitis is an infection of the nervous
system characterized by headache, irritability, vomiting, drowsiness, light-
sensitivity, difficulty in swallowing, lockjaw, incontinence, and diminished
or exaggerated skin sensations. This disorder can be caused by viral
infections acquired from sources other than Simian B Virus infected monkeys.
It may be an allergic or toxic response of the nervous system to invading
organisms such as bacteria or viruses. Neurological damage and intellectual
impairment can follow an attack of this condition. (For more information on
this disorder, choose "Encephalomyelitis" as your search term in the Rare
Disease Database).
Therapies: Standard
Prevention of infection with Simian B Virus among laboratory workers should
include wearing protective clothing when handling potentially infected
monkeys or their tissue cultures. The antiviral drug acyclovir may be
effective against Simian B Virus infection. Other treatment is symptomatic
and supportive.
Therapies: Investigational
Formalin-activated vaccine is under investigation as a possible measure to
prevent Simian B Virus infection. More research is necessary before this
therapy can be made available for general use by laboratory workers exposed
to infected monkeys.
This disease entry is based upon medical information available through
September 1989. Since NORD's resources are limited, it is not possible to
keep every entry in the Rare Disease Database completely current and
accurate. Please check with the agencies listed in the Resources section for
the most current information about this disorder.
Resources
For more information on Simian B Virus, please contact:
National Organization for Rare Disorders (NORD)
P.O. Box 8923
New Fairfield, CT 06812-1783
(203) 746-6518
NIH/National Institute of Allergy and Infections Diseases (NIAID)
9000 Rockville Pike
Bethesda, MD 20892
(301) 496-5717
Centers for Disease Control (CDC)
1600 Clifton Road, NE
Atlanta, GA 30333
(404) 639-3534
References
B VIRUS, HERPESVIRUS SIMIAE: HISTORICAL PERSPECTIVE: A.E. Palmer; J Med
Primatol (1987, issue 16(2)). Pp. 99-130.
THE SPECTRUM OF ANTIVIRAL ACTIVITIES OF ACYCLOVIR IN VITRO AND IN VIVO:
P. Collins; J Antimicrob Chemother (September 1983, issue 12 Suppl B). Pp.
19-27.
SUCCESSFUL TREATMENT OF EXPERIMENTAL B VIRUS (HERPESVIRUS SIMIAE)
INFECTION WITH ACYCLOVIR: E.A. Boulter, et al.; Br Med J (March 8, 1980,
issue 280(6215)). Pp. 681-683.