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$Unique_ID{BRK03763}
$Pretitle{}
$Title{Gastritis, Chronic, Erosive}
$Subject{Gastritis Chronic Erosive Gastritis Varioliform Gastritis Idiopathic
Chronic Erosive Gastritis Crohn's Disease Acute Gastritis Peptic Ulcer
Zollinger-Ellison Syndrome}
$Volume{}
$Log{}
Copyright (C) 1989 National Organization for Rare Disorders, Inc.
719:
Gastritis, Chronic, Erosive
** IMPORTANT **
It is possible that the main title of the article (Chronic, Erosive
Gastritis) is not the name you expected. Please check the SYNONYM listing to
find the alternate names and disorder subdivisions covered by this article.
Synonyms
Gastritis
Varioliform Gastritis
Idiopathic Chronic, Erosive Gastritis
Information on the following diseases can be found in the Related
Disorders section of this report:
Crohn's Disease
Acute Gastritis
Peptic Ulcer
Zollinger-Ellison Syndrome
General Discussion
** REMINDER **
The information contained in the Rare Disease Database is provided for
educational purposes only. It should not be used for diagnostic or treatment
purposes. If you wish to obtain more information about this disorder, please
contact your personal physician and/or the agencies listed in the "Resources"
section of this report.
Chronic, Erosive Gastritis is characterized by many inflamed lesions in
the mucous lining of the stomach. It may be a transitory or a chronic
condition lasting for years.
Symptoms
Chronic, Erosive Gastritis is an inflammation of the stomach characterized
by multiple lesions in the mucous lining causing ulcer-like symptoms. These
symptoms may include a burning and heavy feeling in the pit of the stomach,
mild nausea, vomiting, loss of appetite and weakness. In severe cases there
can be bleeding of the stomach which may result in anemia. Some people with
this disorder, especially chronic aspirin users, may show no apparent
symptoms until the disease has advanced. An accurate diagnosis can be made
by physician's visual inspection of the stomach using a gastroscope.
Causes
The exact cause of Chronic, Erosive Gastritis is unknown. It may be the
result of an infection, over indulgence of alcohol, or persistent use of
aspirin or non-steroidal anti-inflammatory medications such as ibuprofen.
Stress tends to make symptoms worse. Crohn's disease and Sarcoidosis have
been known to be factors in some cases of Chronic, Erosive Gastritis, while
some cases have no apparent cause at all.
Affected Population
Chronic, Erosive Gastritis usually occurs during middle age and is more
common in males than females. Alcoholics and chronic aspirin or ibuprofen
users (e.g. people with arthritis) are more susceptible to this disorder.
Related Disorders
The following disorders may have symptoms similar to Chronic, Erosive
Gastritis. Comparisons may be useful for a differential diagnosis:
Crohn's Disease, also known as ileitis, regional enteritis, or
granulomatous colitis is a form of inflammatory bowel disease characterized
by severe, often granulomatous, chronic inflammation of the wall of the
gastrointestinal tract. In most cases, a segment of the intestines called
the ileum. Crohn's disease can be difficult to manage. Mortality due to the
disease itself, or to complications from the disease, is low. (For more
information on this disorder, choose "Crohn's" as your search term in the
Rare Disease Database).
Acute Erosive Gastritis is an inflammation of the stomach characterized
by lesions in the mucous membranes of the stomach and ulcer-like symptoms.
This type of Gastritis is caused by a variety of stresses such as major
trauma, multiple injuries or serious burns.
Peptic Ulcer is a common disorder usually characterized by a single
lesion of the mucous membranes of the esophagus, stomach or duodenum. These
lesions may be caused by an over secretion of acid or pepsin and are
characterized by pain, heartburn, nausea and vomiting.
Zollinger-Ellison Syndrome is a rare condition characterized by stomach
ulcers and small tumors (usually of the pancreas) which secrete a hormone
that produces excessive amounts of gastric juices in the stomach. These
tumors can also appear in the lower stomach wall, spleen or lymph nodes close
to the stomach. Large amounts of gastric acid can be found in lower stomach
areas where ulcers can form. Ulcers can appear suddenly even in areas where
they are rarely found, may persist following treatment, and can be
accompanied by diarrhea. Prompt medical treatment of these ulcers is
necessary to prevent complications such as bleeding and perforation. (For
more information on this disorder, choose "Zollinger-Ellison" as your search
term in the Rare Disease Database.)
Therapies: Standard
Because Chronic, Erosive Gastritis may cause symptoms similar to other
gastrointestinal disorders, a full medical history must be known before an
effective treatment can be determined. Most cases are usually treated with
acid neutralizing medications (antacids) and H2 blocker drugs such as Zantac
(ranitidine) or Tagamet (cimetidine). Dietary changes and avoiding the
irritating causes such as stomach irritating drugs or stressful situations
are also helpful in eliminating the symptoms of Chronic, Erosive Gastritis.
The prostaglandin E1 analog drug, Cytotec (misoprostol) has proven to be
an effective preventative medication for gastric lesions associated with
high-dose aspirin or ibuprofen therapy. This drug is effective in healing
the gastric mucosal lesions without altering the therapeutic benefits of the
non-steroidal anti-inflammatory drugs given to arthritis patients. Other
treatment is symptomatic and supportive.
Therapies: Investigational
At the present time, a study is being conducted on the effectiveness of the
drug bismuthsubsalicylate as a treatment for Chronic, Erosive Gastritis.
More research must be conducted to determine long-term safety and
effectiveness of this drug.
This disease entry is based upon medical information available through
December 1989. Since NORD's resources are limited, it is not possible to
keep every entry in the Rare Disease Database completely current and
accurate. Please check with the agencies listed in the Resources section for
the most current information about this disorder.
Resources
For more information on Chronic, Erosive Gastritis, please contact:
National Organization for Rare Disorders (NORD)
P.O. Box 8923
New Fairfield, CT 06812-1783
(203) 746-6518
National Digestive Diseases Information Clearinghouse
Box NDDIC
Bethesda, MD 20892
(301) 468-2162
National Foundation for Ileitis and Colitis
444 Park Avenue, South
New York, NY 10016
(212)685-3440
References
INTERNAL MEDICINE, 2nd Ed.: Jay H. Stein, ed-in-chief; Little, Brown and Co.,
1987. Pp. 110.
THE MERCK MANUAL, 15th Ed.: Robert Berkow, M.D. ed-in-chief; Merck, Sharp
& Dohme Laboratories., 1987. Pp. 736.
TREATMENT OF CHRONIC EROSIVE GASTRITIS WITH PREDNISOLONE. M. Farthing,
et al.; GUT, (September 1981, issue 22 (9)). Pp. 759-762.
MECHANISMS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUG-INDUCED GASTRIC
DAMAGE. R. Schoen et al.; AM J MED, (April 1989, issue 86 (4)). Pp. 449-
558.
NEOPLASIA IN CHRONIC EROSIVE (VALIOLIFORM) GASTRITIS. M. Cappell et
al.; DIG DIS SCI, (August 1988, issue 33 (8)). Pp. 1035-1039.
MISOPROSTOL HEALS GASTRODUODENAL INJURY IN PATIENTS WITH RHEUMATOID
ARTHRITIS RECEIVING ASPIRIN. S. Roth et al.; ARCH INTERN MED, (April 1989
issue 149 (4)). Pp. 775-779.
PROSTAGLANDIN E1 ANALOGUE THERAPY IN THE TREATMENT OF REFRACTORY GASTRIC
ULCER IN AN ELDERLY PATIENT. E. Ramsey et al.; ARCH INTERN MED, (October
1988 issue 148 (10)). Pp. 2275-2276.
CHRONIC EROSIVE GASTRITIS: A CLINICAL STUDY. C. Gallagher et al.; AM J
GASTROENTEROL, (April 1987, issue 82 (4)). Pp. 302-306.
CHRONIC EROSIVE GASTRITIS--A RECENTLY RECOGNIZED DISORDER. G. Elta et
al.; DIG DIS SCI (January 1983, issue 28 (1)). Pp. 7-12.