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- $Unique_ID{BRK03339}
- $Pretitle{}
- $Title{sulfonamide antibiotics (oral)}
- $Subject{Gantanol Roche Gantrisin Gulfasin Major Microsulfon CMC multiple
- sulfonamides Neotrizine Lilly Renoquid Glenwood sulfacytine sulfadiazine
- sulfamethizole sulfamethoxazole sulfisoxazole Terfonyl Thiosulfil Forte Squibb
- Ayerst Triple Sulfa systemic Urobak Shionogi USA Anti-infective sulfacytine
- sulfadiazine sulfamethiazole sulfamethoxazole sulfisoxazole bacteria urinary
- tract infections infection}
- $Volume{}
- $Log{
- Gantanol*0333901.scf
- Gantrisin*0333902.scf}
-
- Copyright (C) 1993 Publications International, Ltd.
-
-
- sulfonamide antibiotics (oral)
- ------------------------------------------------------------------------------
-
- BRAND NAMES (Manufacturers)
-
- Gantanol (Roche)
- Gantrisin (Roche)
- Gulfasin (Major)
- Microsulfon (CMC)
- multiple sulfonamides (various manufacturers)
- Neotrizine (Lilly)
- Renoquid (Glenwood)
- sulfacytine (various manufacturers)
- sulfadiazine (various manufacturers)
- sulfamethizole (various manufacturers)
- sulfamethoxazole (various manufacturers)
- sulfisoxazole (various manufacturers)
- Terfonyl (Squibb)
- Thiosulfil Forte (Ayerst)
- Triple Sulfa (systemic) (various manufacturers)
- Urobak (Shionogi USA)
-
- TYPE OF DRUG
-
- Anti-infective
-
- INGREDIENTS AND DOSAGE FORMS
-
- sulfacytine (Renoquid)
- Tablets (250 mg)
-
- sulfadiazine (Microsulfon)
- Tablets (500 mg)
-
- sulfamethiazole (Proklar, Thiosulfil Forte)
- Tablets (250 mg and 500 mg)
-
- sulfamethoxazole (Gamazole, Gantanol, Gantanol DS, Urobak)
- Tablets (500 mg and 1 g)
- Suspension (500 mg per 5-ml spoonful)
-
- sulfisoxazole (Gantrisin, Gulfasin, Lipo-Gantrisin)
- Tablets (500 mg)
- Syrup (500 mg per 5-ml spoonful)
- Pediatric suspension (500 mg per 5-ml spoonful)
- Emulsion, long-acting (1 g per 5-ml spoonful)
-
- multiple sulfonamides (Neotrizine, Sul-Trio MM #2, Terfonyl, Triple
- Sulfa)
- Tablets (167 mg sulfadiazine, 167 mg sulfamerazine, and 167 mg
- sulfamethazine)
- Suspension (167 mg sulfadiazine, 167 mg sulfamerazine, and 167 mg
- sulfamethazine per 5-ml spoonful, with 2% alcohol)
-
- STORAGE
-
- Store at room temperature in the original container.
-
- USES
-
- Sulfonamide antibiotics are a family of related drugs that have activity
- against many types of bacteria. This group of medications is often used to
- treat urinary tract infections, as well as other infections. These
- medications kill the bacteria responsible for the infection.
-
- TREATMENT
-
- Sulfonamide antibiotics should be taken with a full glass of water on an
- empty stomach (either one hour before or two hours after a meal). Several
- additional glasses of water should also be taken every day (unless your doctor
- directs you to do otherwise). Sulfonamide antibiotics work best when the
- level of the medicine in your bloodstream is kept constant. It is best,
- therefore, to take the doses at evenly spaced intervals day and night. For
- example, if you are to take four doses a day, the doses should be spaced about
- six hours apart.
- If the liquid suspension or emulsion form of the sulfonamides has been
- prescribed for you, be sure to shake the bottle well. The contents tend to
- settle on the bottom of the bottle, so it is necessary to shake the container
- to distribute the ingredients evenly and equalize the doses. Be sure to use
- specially marked droppers or spoons to accurately measure the correct amount
- of liquid. Household teaspoons vary in size and may not give you the correct
- dosage.
- If you miss a dose, take the missed dose as soon as possible, unless it
- is almost time for your next dose. In that case, if you are taking two doses
- a day, space the missed dose and the following dose five to six hours apart;
- if you are taking three or more doses a day, space the missed dose and the
- following dose two to four hours apart, or double the next dose. Then return
- to your regular dosing schedule.
- It is very important to continue to take these medications for the entire
- time prescribed by your doctor (usually ten days), even if the symptoms
- disappear before the end of that period. If you stop taking the drug too
- soon, resistant bacteria are given a chance to continue growing, and your
- infection could recur.
-
- SIDE EFFECTS
-
- Minor.
-
- Diarrhea, dizziness, headache, loss of appetite, nausea, or vomiting. As
- your body adjusts to the medication, these side effects should disappear.
- These drugs can increase your sensitivity to sunlight. You should,
- therefore, avoid prolonged exposure to sunlight and sunlamps. Wear protective
- clothing and sunglasses; and use an effective sunscreen, but not one that
- contains para-aminobenzoic acid (PABA). PABA interferes with the
- antibacterial activity of this medication.
-
- Major.
-
- Tell your doctor about any side effects that are persistent or
- particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
- aching of joints and muscles; blood in the urine; difficulty in swallowing;
- itching; lower back pain; pain while urinating; pale skin; redness,
- blistering, or peeling of the skin; skin rash; sore throat and fever; swelling
- of the front part of the neck; unusual bleeding or bruising; unusual
- tiredness; or yellowing of the eyes or skin. Also, if your symptoms of
- infection seem to be getting worse rather than improving, you should contact
- your doctor.
-
- INTERACTIONS
-
- Sulfonamides interact with several types of drugs:
- 1. Para-aminobenzoic acid products (sunscreens) can decrease the
- effectiveness of the sulfonamides.
- 2. The activity and side effects of anticoagulants (blood thinners, such
- as warfarin), oral antidiabetic medications, methotrexate, aspirin, phenytoin,
- and thiopental may be increased when sulfonamides are also taken.
- 3. Oxyphenbutazone, phenylbutazone, methenamine, probenecid, and
- sulfinpyrazone can increase the toxicity of the sulfonamides.
- BE SURE TO TELL YOUR DOCTOR about any medications you are currently
- taking, especially any of those listed above.
-
- WARNINGS
-
- * Before starting to take this medication, tell your doctor about any
- unusual or allergic reactions you have had to any medications, especially to
- sulfonamide antibiotics or other sulfa drugs, including diuretics (water
- pills), dapsone, sulfoxone, oral antidiabetics, and oral antiglaucoma
- medication.
- * Tell your doctor if you now have or if you have ever had
- glucose-6-phosphate dehydrogenase (G6PD) deficiency, liver disease, porphyria,
- or kidney disease.
- * Before having surgery or any other medical or dental treatment, be sure
- to tell your doctor or dentist that you are taking a sulfonamide antibiotic.
- * This medication has been prescribed for your current infection only.
- Another infection later on, or one that someone else has, may require a
- different medicine. You should not give your medicine to other people, and
- you should not use it for other infections, unless your doctor specifically
- directs you to do so.
- * Be sure to tell your doctor if you are pregnant. These medications, if
- given to a woman late in pregnancy, can be toxic to the fetus. Also, tell
- your doctor if you are breast-feeding an infant. Sulfonamides can pass into
- breast milk and may cause side effects in a small number of nursing
- infants--those who have glucose-6-phosphate dehydrogenase (G6PD) deficiency.
- In addition, you should not give sulfonamides to an infant less than one month
- of age, unless your doctor specifically directs you to do so.
-
- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
-