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1994-01-17
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$Unique_ID{BRK03318}
$Pretitle{}
$Title{pseudoephedrine, carbinoxamine, and dextromethorphan combination}
$Subject{Carbodec DM Rugby Cardec Mycadec My-K Labs Pseudo-Car Geneva Generics
Rondec-DM Ross Tussafed Everett Adrenergic decongestant antihistamine
suppressant pseudoephedrine carbinoxamine dextromethorphan coughs upper
respiratory tract infections hay fever allergies sinusitis inflammation
sinuses constricting narrowing blood vessels nasal passages swelling
congestion histamine allergic reaction allergy cough reflex center brain}
$Volume{}
$Log{}
Copyright (C) 1993 Publications International, Ltd.
pseudoephedrine, carbinoxamine, and dextromethorphan combination
------------------------------------------------------------------------------
BRAND NAMES (Manufacturers)
Carbodec DM (Rugby)
Cardec DM (various manufacturers)
Mycadec DM (My-K Labs)
Pseudo-Car DM (Geneva Generics)
Rondec-DM (Ross)
Tussafed (Everett)
TYPE OF DRUG
Adrenergic (decongestant), antihistamine, and cough suppressant
INGREDIENTS
pseudoephedrine, carbinoxamine, and dextromethorphan
DOSAGE FORMS
Oral syrup (60 mg pseudoephedrine, 4 mg carbinoxamine, and 15 mg
dextromethorphan per 5-ml spoonful)
Oral drops (25 mg pseudoephedrine, 2 mg carbinoxamine, and 4 mg
dextromethorphan per 1-ml dropperful)
STORAGE
Pseudoephedrine, carbinoxamine, and dextromethorphan combination oral
syrup and oral drops should be stored at room temperature in a tightly closed,
light-resistant glass container. Avoid exposing these medications to
excessive heat.
USES
This drug combination is used to relieve coughs and the symptoms of upper
respiratory tract infections, hay fever and other allergies, and sinusitis
(inflammation of the sinuses).
Pseudoephedrine belongs to a group of drugs known as adrenergic agents
(decongestants). They act by constricting (narrowing) blood vessels in the
nasal passages to reduce swelling and congestion.
Carbinoxamine belongs to a group of drugs known as antihistamines, which
block the actions of histamine, a chemical released by the body during an
allergic reaction. It is, therefore, used to relieve or prevent symptoms of
allergy.
Dextromethorphan is a cough suppressant, which acts at the cough reflex
center in the brain.
TREATMENT
In order to avoid stomach upset, you can take this medicine with food or
with a full glass of water (unless your doctor directs you to do otherwise).
The oral drops should be measured carefully with the dropper provided.
The oral syrup should be measured carefully with a specially designed 5-ml
measuring spoon. An ordinary kitchen teaspoon is not accurate enough.
If you miss a dose of this medication, take the missed dose as soon as
possible, unless it is almost time for your next dose. In that case, do not
take the missed dose at all; just return to your regular dosing schedule. Do
not double the next dose.
SIDE EFFECTS
Minor.
Abdominal pain, blurred vision, decreased sweating, diarrhea, dizziness,
drowsiness, dry mouth, headache, heartburn, loss of appetite, nausea,
nervousness, sleeping problems, vomiting, or weakness. These side effects
should disappear as your body adjusts to the medication.
Chew sugarless gum or suck on ice chips or hard candy to reduce mouth
dryness.
If you feel dizzy or light-headed, sit or lie down for a while; get up
slowly from a sitting or reclining position, and be careful on stairs.
This medication can increase your sensitivity to sunlight. Avoid
prolonged exposure to sunlight and sunlamps. Wear protective clothing, and
use an effective sunscreen.
In order to avoid difficulty in falling asleep, you should take the last
dose of this medication several hours before bedtime.
Major.
Tell your doctor about any side effects that are persistent or
particularly bothersome, especially chest pain, difficult or painful
urination, difficulty in breathing, hallucinations, pallor, palpitations,
seizures, or tremors.
INTERACTIONS
This medication can interact with several types of drugs:
1. Concurrent use of it with central nervous system depressants (drugs
that slow the activity of the brain and spinal cord), such as alcohol,
barbiturates, benzodiazepine tranquilizers, muscle relaxants, narcotics, pain
medications, and phenothiazine tranquilizers, or with tricyclic
antidepressants can cause extreme drowsiness.
2. Monoamine oxidase (MAO) inhibitors (isocarboxazid, pargyline,
phenelzine, or tranylcypromine), beta blockers (acebutolol, atenolol,
betaxolol, carteolol, esmolol, labetalol, metoprolol, nadolol, penbutolol,
pindolol, propranolol, or timolol), and tricyclic antidepressants can increase
the side effects of this drug. At least 14 days should separate the use of
this drug and the use of an MAO inhibitor.
3. The side effects of the antihistamine part of this medication may be
increased by quinidine, procainamide, haloperidol, and phenothiazine
tranquilizers.
4. The side effects of the decongestant component may be increased by
digoxin or over-the-counter (nonprescription) asthma, allergy, cough, cold,
diet, or sinus preparations.
5. The blood-pressure-lowering effects of guanethidine, methyldopa, and
reserpine may be decreased by this drug.
Before starting pseudoephedrine, carbinoxamine, and dextromethorphan
combination, TELL YOUR DOCTOR about any medications you are curently taking.
WARNINGS
* Tell your doctor about unusual or allergic reactions you have had to
any medications, especially to carbinoxamine or other antihistamines (such as
azatadine, chlorpheniramine, clemastine, cyproheptadine, dexchlorpheniramine,
dimenhydrinate, dimethindene, diphenhydramine, diphenylpyraline, doxylamine,
hydroxyzine, promethazine, pyrilamine, trimeprazine, tripelennamine, and
triprolidine), to pseudoephedrine or other adrenergic agents (such as
albuterol, amphetamines, ephedrine, epinephrine, isoproterenol,
metaproterenol, norepinephrine, phenylpropanolamine, and terbutaline), or to
dextromethorphan.
* Tell your doctor if you have ever had diabetes mellitus, glaucoma,
heart or blood vessel disease, high blood pressure, myasthenia gravis,
obstructed bladder or intestinal tract, peptic ulcers, enlarged prostate, or
thyroid disease.
* Because this drug can reduce sweating and heat release from the body,
avoid excessive work and exercise in hot weather, and do not take hot baths,
showers, and saunas.
* This medication can cause drowsiness. Your ability to perform tasks
that require alertness.
* Tell your doctor if you are pregnant. The safe use of this drug in
human pregnancy has not been established. Also, tell your doctor if you are
breast-feeding an infant. Small amounts of this medication pass into breast
milk and may cause unusual excitement or irritability in nursing infants.
----------------
The material contained here is "FOR INFORMATION ONLY" and should not replace
the counsel and advice of your personal physician. Promptly consulting your
doctor is the best path to a quick and successful resolution of any medical
problem.