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CD-ROM Today (UK) (Spanish) 15
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0309
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03098.txt
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1994-01-17
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$Unique_ID{BRK03098}
$Pretitle{}
$Title{clorazepate}
$Subject{ Tranxene-SD Abbott Tranxene T-Tabs Abbott Benzodiazepine sedative
hypnotic clorazepate anxiety seizures alcohol withdrawal depressant central
nervous system nervousness}
$Volume{}
$Log{
Tranxene-SD 11.25 mg*0309801.scf
Tranxene-SD 22.5 mg*0309802.scf
Tranxene T-Tabs 3.75 mg*0309803.scf
Tranxene T-Tabs 7.5 mg*0309804.scf
Tranxene T-Tabs 15 mg*0309805.scf}
Copyright (C) 1993 Publications International, Ltd.
clorazepate
------------------------------------------------------------------------------
BRAND NAMES (Manufacturers)
clorazepate (various manufacturers)
Tranxene-SD (Abbott)
Tranxene T-Tabs (Abbott)
TYPE OF DRUG
Benzodiazepine sedative/hypnotic
INGREDIENT
clorazepate
DOSAGE FORMS
Capsules (3.75 mg, 7.5 mg, and 15 mg)
Tablets (3.75 mg, 7.5 mg, 11.25 mg, 15 mg, and 22.5 mg)
STORAGE
This medication should be stored at room temperature in tightly closed,
light-resistant containers.
USES
Clorazepate is prescribed to treat the symptoms of anxiety and sometimes
to treat seizures and alcohol withdrawal symptoms. It is not clear exactly
how this medicine works, but it may relieve anxiety by acting as a depressant
of the central nervous system. Clorazepate is used to relieve nervousness.
It is effective for this purpose, but it is important to remove the cause of
the anxiety as well.
TREATMENT
This medication should be taken exactly as directed by your doctor. It
can be taken with food or a full glass of water if stomach upset occurs. Do
not take this medication with a dose of antacids, since they may retard its
absorption.
If you are taking this medication regularly and you miss a dose, take the
missed dose immediately if you remember within an hour. If more than an hour
has passed, skip the dose you missed and wait for the next scheduled dose. Do
not double the next dose.
SIDE EFFECTS
Minor.
Bitter taste in the mouth, constipation, depression, diarrhea, dizziness,
drowsiness (after a night's sleep), dry mouth, excessive salivation, fatigue,
flushing, headache, heartburn, loss of appetite, nausea, nervousness,
sweating, or vomiting. As your body adjusts to the medicine, these side
effects should disappear.
To relieve constipation, increase the amount of fiber in your diet (fresh
fruits and vegetables, salads, bran, and whole-grain breads), exercise, and
drink more water (unless your doctor directs you to do otherwise).
Dry mouth can be relieved by chewing sugarless gum or by sucking on ice
chips.
If you feel dizzy, sit or lie down for a while; get up slowly from a
sitting or reclining position, and be careful on stairs.
Major.
Tell your doctor about any side effects that are persistent or
particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
blurred or double vision, chest pain, difficulty in urinating, fainting,
falling, fever, joint pain, hallucinations, mouth sores, nightmares,
palpitations, rash, severe depression, shortness of breath, slurred speech,
sore throat, uncoordinated movements, unusual excitement, unusual tiredness,
or yellowing of the eyes or skin.
INTERACTIONS
Clorazepate interacts with several other types of drugs:
1. To prevent oversedation, this drug should not be taken with alcohol or
other sedative drugs, central nervous system depressants (such as
antihistamines, barbiturates, muscle relaxants, pain medicines, narcotics,
medicines for seizures, and phenothiazine tranquilizers), or with
antidepressants.
2. This medication may decrease the effectiveness of carbamazepine,
levodopa, and oral anticoagulants (blood thinners) and may increase the
effects of phenytoin.
3. Disulfiram, oral contraceptives (birth control pills), isoniazid, and
cimetidine can increase the blood levels of clorazepate, which can lead to
increased sedation.
4. Concurrent use of rifampin may decrease the effectiveness of
clorazepate.
BE SURE TO TELL YOUR DOCTOR about any medications you are currently
taking, especially any of those listed above.
WARNINGS
* Tell your doctor about unusual or allergic reactions you have had to
any medications, especially to clorazepate or other benzodiazepine
tranquilizers (such as alprazolam, chlordiazepoxide, diazepam, flurazepam,
halazepam, lorazepam, oxazepam, prazepam, temazepam, and triazolam).
* Tell your doctor if you now have or if you have ever had liver disease,
kidney disease, epilepsy, lung disease, myasthenia gravis, porphyria,
depression, or mental illness.
* This medicine can cause drowsiness. Avoid tasks that require
alertness, such as driving a car or using potentially dangerous equipment.
* This medication has the potential for abuse and must be used with
caution. Tolerance may develop quickly; do not increase the dosage without
first consulting your doctor. It is also important not to stop taking this
drug suddenly if you have been taking it in large amounts or if you have used
it for several weeks. Your doctor may want to reduce the dosage gradually.
* This is a safe drug when used properly. When it is combined with other
sedative drugs or alcohol, however, serious side effects may develop.
* Be sure to tell your doctor if you are pregnant. This medicine may
increase the chance of birth defects if it is taken during the first three
months of pregnancy. In addition, too much use of this medicine during the
last six months of pregnancy may cause the baby to become dependent on it.
This may result in withdrawal side effects in the newborn. Also, use of this
medicine during the last weeks of pregnancy may cause excessive drowsiness,
slowed heartbeat, and breathing difficulties in the newborn. Tell your doctor
if you are breast-feeding an infant. This medicine can pass into the breast
milk and cause excessive drowsiness, slowed heartbeat, and breathing
difficulties in the nursing infant.
----------------
The material contained here is "FOR INFORMATION ONLY" and should not replace
the counsel and advice of your personal physician. Promptly consulting your
doctor is the best path to a quick and successful resolution of any medical
problem.