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03011.txt
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1994-01-17
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$Unique_ID{BRK03011}
$Pretitle{}
$Title{acetaminophen and propoxyphene combination}
$Subject{Darvocet-N 50 Lilly 100 Dolene AP-65 Lederle Genagesic Goldline
Propacet Lemmon propoxyphene hydrochloride acetaminophen napsylate Wygesic
Wyeth Analgesic combination acetaminophen pain narcotic analgesic central
nervous system brain spinal cord}
$Volume{}
$Log{
Darvocet-N 50*0301101.scf}
Copyright (C) 1993 Publications International, Ltd.
acetaminophen and propoxyphene combination
------------------------------------------------------------------------------
BRAND NAMES (Manufacturers)
Darvocet-N 50 (Lilly)
Darvocet-N 100 (Lilly)
Dolene AP-65 (Lederle)
Genagesic (Goldline)
Propacet 100 (Lemmon)
propoxyphene hydrochloride with acetaminophen (various manufacturers)
propoxyphene napsylate with acetaminophen (various manufacturers)
Wygesic (Wyeth)
TYPE OF DRUG
Analgesic combination
INGREDIENTS
acetaminophen and propoxyphene
DOSAGE FORMS
Tablets (325 mg acetaminophen with 50 mg propoxyphene napsylate; 650 mg
acetaminophen with 100 mg propoxyphene napsylate; 650 mg acetaminophen with 6
mg propoxyphene hydrochloride)
Capsules (650 mg acetaminophen with 65 mg propoxyphene hydrochloride)
STORAGE
Acetaminophen and propoxyphene combination tablets and capsules should be
stored at room temperature in tightly closed containers.
USES
This medication is used to relieve moderate to severe pain. Propoxyphene
is a narcotic analgesic that acts on the central nervous system (brain and
spinal cord) to relieve pain.
TREATMENT
In order to avoid stomach upset, you can take this medication with food
or milk.
This medication works best if you take it at the onset of pain, rather
than waiting until the pain becomes intense.
If you are taking this acetaminophen and propoxyphene combination on a
regular schedule and you miss a dose, take the missed dose as soon as
possible, unless you are nearing the time for the next dose. In that case, do
not take the missed dose at all; just return to your regular dosing schedule.
It is important that you do not double the next dose.
SIDE EFFECTS
Minor.
Constipation, dizziness, drowsiness, dry mouth, false sense of
well-being, flushing, light-headedness, loss of appetite, nausea, painful or
difficult urination, or sweating. These side effects should disappear as your
body adjusts to the drug.
If you are constipated, increase the amount of fiber in your diet (fresh
fruits and vegetables, salads, bran, and whole-grain breads), exercise, and
drink more water (unless your doctor directs you to do otherwise).
To reduce excessive mouth dryness, you may want to chew sugarless gum or
you may want to suck on ice chips or hard candy.
If you feel dizzy or light-headed, sit or lie down for a while; get up
from a sitting or lying position slowly, and be careful on stairs.
Major.
Tell your doctor about any side effects that are persistent or
particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
anxiety, difficulty in breathing, excitation, fatigue, palpitations, rash,
restlessness, sore throat and fever, tremors, unusual bleeding or bruising,
weakness, or yellowing of the eyes or skin.
INTERACTIONS
This medication interacts with several other types of drugs:
1. Concurrent use of acetaminophen and propoxyphene combination with
other central nervous system depressants (such as alcohol, antihistamines,
barbiturates, benzodiazepine tranquilizers, muscle relaxants, and
phenothiazine tranquilizers) or with tricyclic antidepressants can possibly
cause extreme drowsiness.
2. A monoamine oxidase (MAO) inhibitor taken within 14 days of this
medication can lead to unpredictable and severe side effects.
3. Long-term use and high doses of acetaminophen can increase the effects
of oral anticoagulants (blood thinners, such as warfarin), which may lead to
bleeding complications.
4. Anticonvulsants (antiseizure medication), barbiturates, and alcohol
can increase the liver toxicity caused by large doses of the acetaminophen
portion of this medication.
5. The propoxyphene portion of this medication decreases the elimination
of carbamazepine from the body, which can lead to an increase in side effects.
Before starting to take this medication, BE SURE TO TELL YOUR DOCTOR
about any medications you are currently taking, especially any of those listed
above.
WARNINGS
* Tell your doctor about unusual or allergic reactions you have had to
any medications, especially to acetaminophen, propoxyphene, or other narcotic
analgesics (such as codeine, hydrocodone, hydromorphone, meperidine,
methadone, morphine, and oxycodone).
* Tell your doctor if you now have or if you have ever had an acute
abdominal condition, asthma, blood disorders, brain disease, colitis,
epilepsy, gallstones or gallbladder disease, head injuries, heart disease,
kidney disease, liver disease, lung disease, mental illness, prostate disease,
thyroid disease, or urethral strictures.
* If this drug makes you dizzy or drowsy, do not take part in any
activity that requires alertness, such as driving a car.
* Before having surgery or any other medical or dental treatment, be sure
to tell your doctor or dentist that you are taking this medication.
* Because this product contains propoxyphene, it has the potential for
abuse and must be used with caution. Usually, it should not be taken on a
regular schedule for longer than ten days at a time. Tolerance develops
quickly; do not increase the dosage or stop taking the drug abruptly unless
you first consult your doctor. If you have been taking large amounts of this
medication for long periods, you may experience a withdrawal reaction (muscle
aches, diarrhea, gooseflesh, runny nose, nausea, vomiting, shivering,
trembling, stomach cramps, sleep disorders, irritability, weakness, excessive
yawning, or sweating). Your doctor may, therefore, want to reduce the dosage
gradually to prevent or minimize this response.
* Because this product contains acetaminophen, additional medications
that contain acetaminophen should not be taken without your doctor's approval.
Check the labels on over-the-counter (nonprescription) pain, sinus, allergy,
asthma, diet, cough, and cold products to see if they contain acetaminophen.
* Be sure to tell your doctor if you are pregnant. The effects of this
medication during pregnancy have not been thoroughly studied in humans.
Propoxyphene used regularly in large doses during pregnancy can result in
addiction of the fetus, leading to withdrawal symptoms (irritability,
excessive crying, tremors, fever, vomiting, diarrhea, sneezing, or excessive
yawning) at birth. Also, tell your doctor if you are breast-feeding an
infant. Small amounts of this medication may pass into breast milk and cause
excessive drowsiness in the nursing infant.
----------------
The material contained here is "FOR INFORMATION ONLY" and should not replace
the counsel and advice of your personal physician. Promptly consulting your
doctor is the best path to a quick and successful resolution of any medical
problem.