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- $Unique_ID{BRK01323}
- $Pretitle{}
- $Title{What is "Acromegaly"?}
- $Subject{pituitary acromegaly endocrine glands metabolism cancer cancers
- neoplasm neoplasms gland bromocriptine large extremity tumor adenoma growth
- hormone gh sella turcica extremities finger fingers hand hands foot feet
- acromegalia gigantism}
- $Volume{C-22, B-22}
- $Log{
- Cross Section of the Brain and Skull*0002401.scf
- Location and Function of the Endocrine Glands*0002901.scf}
-
- Copyright (c) 1991-92,1993 Tribune Media Services, Inc.
-
-
- What is "Acromegaly"?
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-
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-
- QUESTION: My son has "Acromegaly" secondary to a large pituitary tumor.
- Could you please give me some information about this? He is taking
- Bromocriptine. Could you please tell us something about that? I haven't been
- able to find any information about any of this.
-
- ------------------------------------------------------------------------------
-
- ANSWER: The term acromegaly comes from the Greek "acros" meaning "extremity"
- and "megale" meaning "great", for large fingers, hands and feet are
- distinguishing marks of this disorder. It almost always is caused by a tumor
- (adenoma) of the pituitary gland, which secretes excessive amounts of the
- growth hormone (GH). Although this may happen at any age, it is most
- frequently seen between the ages of 30 to 50, a time of life when bone growth
- is complete. When the hormone is secreted it causes the soft tissues of the
- fingers and feet to swell, and a coarsening of the features of the face. The
- skin may become thicker and darken, and there is a growth of coarse body hair.
- The mandible grows, causing the jaw to protrude and the cartilage of the
- larynx (voice box) grows, creating a deep, husky voice. After a period of
- time, the growth of rib structures creates a barrel chest. Sugar metabolism
- is affected in about half the cases, but causes a clinical diabetes in only 10
- percent of the patients. The diagnosis can be made by x-rays which show the
- changes in the bony structures, and can disclose an enlargement of the sella
- turcica, the area where the pituitary gland is found. Blood tests will also
- show that the levels of GH are elevated. Bromocriptine mesylate can be used
- to help lower the levels of GH, and is effective in some cases. However
- either surgery or radiation therapy is generally recommended to remove or
- destroy the pituitary tumor. The results of radiation therapy with
- supervoltage radiation may not be seen for several years, when the levels of
- GH finally fall to normal, but is a procedure that rarely damages the cranial
- nerves or other tissues. There are many types of treatment and the techniques
- may vary from one institution to another.
-
- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
-
-