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- $Unique_ID{BRK00590}
- $Pretitle{}
- $Title{Pernicious Anemia and Vitamin B12 Treatment}
- $Subject{pernicious anemia B12 vitamins digestive Blood liver inherited immune
- PA injections injection}
- $Volume{I-7}
- $Log{
- Anemia*0009200.tid
- What is Anemia?*0009201.scf
- Symptoms of Anemia*0009202.scf
- Dietary Cause of Anemia*0009203.scf
- Some Types of Anemia are Inherited*0009204.scf}
-
- Copyright (c) 1991-92,1993 Tribune Media Services, Inc.
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-
- Pernicious Anemia and Vitamin B12 Treatment
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- QUESTION: I have suffered for many years with a condition called pernicious
- anemia. It seems to be a disease that is in my family as my two other sisters
- and brother have it as well. The only treatment offered to me seems to be
- vitamin B12 injections. Could you tell me a bit about this disease, and if
- you think a single injection each month is sufficient treatment?
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-
- ANSWER: Although Vitamin B12 is readily available in meat, many other animal
- protein foods as well as legumes, it can not get into our system without the
- presence of a substance named "the intrinsic factor" which is secreted by the
- parietal cells which form part of the tissue that lines the stomach. The B12
- is stored in the liver in enormous quantities, sufficient for the body's needs
- for a three to five year period. Therefore, when the mucosal tissue of the
- stomach begins to atrophy and shrink, it takes a long period of time before
- the lack of the vitamin can be detected and before the anemia becomes evident.
- As the anemia develops the body adapts, hiding the disease for even longer
- periods of time. We are beginning to learn that both inherited and immune
- factors may play important roles in the development of this condition, and so
- the fact that your brother and sisters also have pernicious anemia (PA) is not
- unusual. Since the B12 cannot be absorbed through the digestive tract, it is
- replaced by injections. In the first stages of treatment, regular injections
- are given intramuscularly as frequently as 2 to 4 times a week to allow the
- body physiology to resume producing red cells normally, and to replace all the
- reserves the liver can hold. This may take about six weeks, but once the
- blood tests show a normal picture, the frequency of the injection may be
- reduced to once monthly. It would seem that you have now reached this stage
- and therefore the once monthly schedule you are on is appropriate. Since this
- does not change the underlying cause of the anemia, B12 injections must be
- continued throughout life.
-
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-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
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