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Text File  |  1996-05-06  |  247KB  |  2,364 lines

  1. %!PS-Adobe-2.0
  2. %%Creator: dvips 5.47 Copyright 1986-91 Radical Eye Software
  3. %%Title: review.dvi
  4. %%Pages: 36 1
  5. %%BoundingBox: 0 0 612 792
  6. %%EndComments
  7. %%BeginProcSet: tex.pro
  8. /TeXDict 200 dict def TeXDict begin /N /def load def /B{bind def}N /S /exch
  9. load def /X{S N}B /TR /translate load N /isls false N /vsize 10 N /@rigin{
  10. isls{[0 1 -1 0 0 0]concat}if 72 Resolution div 72 VResolution div neg scale
  11. Resolution VResolution vsize neg mul TR matrix currentmatrix dup dup 4 get
  12. round 4 exch put dup dup 5 get round 5 exch put setmatrix}N /@letter{/vsize 10
  13. N}B /@landscape{/isls true N /vsize -1 N}B /@a4{/vsize 10.6929133858 N}B /@a3{
  14. /vsize 15.5531 N}B /@ledger{/vsize 16 N}B /@legal{/vsize 13 N}B /@manualfeed{
  15. statusdict /manualfeed true put}B /@copies{/#copies X}B /FMat[1 0 0 -1 0 0]N
  16. /FBB[0 0 0 0]N /nn 0 N /IE 0 N /ctr 0 N /df-tail{/nn 8 dict N nn begin
  17. /FontType 3 N /FontMatrix fntrx N /FontBBox FBB N string /base X array
  18. /BitMaps X /BuildChar{CharBuilder}N /Encoding IE N end dup{/foo setfont}2
  19. array copy cvx N load 0 nn put /ctr 0 N[}B /df{/sf 1 N /fntrx FMat N df-tail}
  20. B /dfs{div /sf X /fntrx[sf 0 0 sf neg 0 0]N df-tail}B /E{pop nn dup definefont
  21. setfont}B /ch-width{ch-data dup length 5 sub get}B /ch-height{ch-data dup
  22. length 4 sub get}B /ch-xoff{128 ch-data dup length 3 sub get sub}B /ch-yoff{
  23. ch-data dup length 2 sub get 127 sub}B /ch-dx{ch-data dup length 1 sub get}B
  24. /ch-image{ch-data dup type /stringtype ne{ctr get /ctr ctr 1 add N}if}B /id 0
  25. N /rw 0 N /rc 0 N /gp 0 N /cp 0 N /G 0 N /sf 0 N /CharBuilder{save 3 1 roll S
  26. dup /base get 2 index get S /BitMaps get S get /ch-data X pop /ctr 0 N ch-dx 0
  27. ch-xoff ch-yoff ch-height sub ch-xoff ch-width add ch-yoff setcachedevice
  28. ch-width ch-height true[1 0 0 -1 -.1 ch-xoff sub ch-yoff .1 add]{ch-image}
  29. imagemask restore}B /D{/cc X dup type /stringtype ne{]}if nn /base get cc ctr
  30. put nn /BitMaps get S ctr S sf 1 ne{dup dup length 1 sub dup 2 index S get sf
  31. div put}if put /ctr ctr 1 add N}B /I{cc 1 add D}B /bop{userdict /bop-hook
  32. known{bop-hook}if /SI save N @rigin 0 0 moveto}N /eop{clear SI restore
  33. showpage userdict /eop-hook known{eop-hook}if}N /@start{userdict /start-hook
  34. known{start-hook}if /VResolution X /Resolution X 1000 div /DVImag X /IE 256
  35. array N 0 1 255{IE S 1 string dup 0 3 index put cvn put}for}N /p /show load N
  36. /RMat[1 0 0 -1 0 0]N /BDot 260 string N /rulex 0 N /ruley 0 N /v{/ruley X
  37. /rulex X V}B /V statusdict begin /product where{pop product dup length 7 ge{0
  38. 7 getinterval(Display)eq}{pop false}ifelse}{false}ifelse end{{gsave TR -.1 -.1
  39. TR 1 1 scale rulex ruley false RMat{BDot}imagemask grestore}}{{gsave TR -.1
  40. -.1 TR rulex ruley scale 1 1 false RMat{BDot}imagemask grestore}}ifelse B /a{
  41. moveto}B /delta 0 N /tail{dup /delta X 0 rmoveto}B /M{S p delta add tail}B /b{
  42. S p tail}B /c{-4 M}B /d{-3 M}B /e{-2 M}B /f{-1 M}B /g{0 M}B /h{1 M}B /i{2 M}B
  43. /j{3 M}B /k{4 M}B /w{0 rmoveto}B /l{p -4 w}B /m{p -3 w}B /n{p -2 w}B /o{p -1 w
  44. }B /q{p 1 w}B /r{p 2 w}B /s{p 3 w}B /t{p 4 w}B /x{0 S rmoveto}B /y{3 2 roll p
  45. a}B /bos{/SS save N}B /eos{clear SS restore}B end
  46. %%EndProcSet
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  586. (drug's)f(action,)g(lik)o(e)e(the)i(harmonics)f(from)122 1566
  587. y(the)d(fundamen)o(tal)g(to)h(the)f(inaudible)g(whic)o(h,)g(tak)o(en)g(in)g
  588. (concert,)g(de\014nes)h(the)f(drug.)21 b(With)122 1626 y(m)o(uscial)e
  589. (instrumen)o(ts,)h(these)h(comp)q(onen)o(ts)g(can)g(b)q(e)h(sho)o(wn)f(as)h
  590. (sine)f(w)o(a)o(v)o(es)g(on)g(an)h(os-)122 1686 y(cilloscop)q(e....)34
  591. b(But)21 b(in)g(psyc)o(hopharmacology?)36 b(There)21 b(is)g(no)h(pical)d
  592. (elemen)o(ts)h(of)j(structure)f(activit)o(y)f(relationships)h(are)h
  593. (brie\015y)e(summarized,)0 541 y(based)g(on)f(a)h(surv)o(ey)f(of)g(the)g(h)o
  594. (uman)f(activit)o(y)g(data)i(presen)o(ted)e(b)o(y)h(Sh)o(ulgin:)73
  595. 636 y Fd(The)j(\\eth)n(ylamine")c(side)j(c)n(hain:)0 727 y
  596. Fk(a\))h(The)g(eth)o(ylamine)d(side)i(c)o(hain)h(can)g(tak)o(e)f(the)g(follo)
  597. o(wing)h(forms:)25 b(eth)o(ylamine)16 b(or)j(isoprop)o(ylamine,)90
  598. 788 y(and)14 b(an)g(OH)f(group)h(ma)o(y)e(or)h(ma)o(y)f(not)i(b)q(e)g(placed)
  599. e(on)i(the)f(nitrogen.)21 b(An)o(y)12 b(other)i(structure)f(causes)90
  600. 848 y(a)k(drop-o\013)h(in)d(b)q(oth)j(quan)o(titativ)o(e)c(and)j(qualitativ)o
  601. (e)e(e\013ectiv)o(eness.)0 908 y(b\))k(The)g(isoprop)o(ylamine)e(c)o(hain)h
  602. (generally)g(has)h(a)h(higher)e(p)q(otency)h(and)h(longer)e(duration)i(than)f
  603. (the)90 968 y(eth)o(ylamine)d(c)o(hain,)k(ho)o(w)o(ev)o(er)e(the)h(eth)o
  604. (ylamine)d(c)o(hain)j(is)g(generally)f(found)i(to)g(b)q(e)f(qualitativ)o(ely)
  605. 90 1028 y(sup)q(erior)g(and)g(\(at)g(least)g(in)f(the)h(case)f(of)h(the)g
  606. (sulfur)f(analogues\))i(has)g(a)f(more)e(consisten)o(t)h(dose-)90
  607. 1088 y(resp)q(onse)f(relationship.)0 1149 y(c\))e(The)f(presence)g(or)i
  608. (absence)e(of)i(an)f(OH)f(group)i(on)f(the)g(nitrogen)g(has)h(little)d
  609. (e\013ect)h(on)i(either)d(qualit)o(y)90 1209 y(or)k(p)q(otency)l(.)73
  610. 1304 y Fd(The)i(phen)n(yl)f(ring:)0 1395 y Fk(a\))f(The)f(ring)g(should)h(ha)
  611. o(v)o(e)e(alk)o(o)o(xy)g(and/or)j(alkylthio)d(substituen)o(ts.)0
  612. 1455 y(b\))h(The)h(greatest)f(activit)o(y)f(is)h(found)g(with)h(t)o(w)o(o)f
  613. (alk)o(o)o(xy-alkylthio)e(substituen)o(ts.)0 1516 y(c\))19
  614. b(The)f(t)o(w)o(o)h(alk)o(o)o(xy-alkylthio)e(substituen)o(ts)i(pro)o(vide)f
  615. (greatest)h(activit)o(y)e(if)i(they)f(are)h(in)g(the)f(2,5)i(or)90
  616. 1576 y(2,6)d(p)q(ositions.)0 1636 y(d\))f(The)f(alk)o(o)o(xy-alkylthio)f
  617. (substituen)o(ts)i(pro)o(vide)f(optimal)f(activit)o(y)g(if)h(the)g(alkyl)g
  618. (group)i(is)e(a)h(meth)o(yl.)90 1696 y(An)d(eth)o(yl)g(group)i(at)f(the)f(5)i
  619. (p)q(osition)f(pro)q(duces)g(a)h(p)q(otency)e(similar)f(to)i(the)g(meth)o(yl)
  620. d(analogue,)k(but)90 1756 y(sho)o(ws)i(a)g(m)o(uc)o(h)d(longer)i(duration)h
  621. (\(often)f(to)q(o)h(long\).)22 b(An)16 b(eth)o(yl)f(group)i(at)g(the)f(2)g(p)
  622. q(osition)h(sho)o(ws)90 1817 y(a)g(decrease)e(in)h(p)q(otency)g(and)h(qualit)
  623. o(y)l(.)0 1877 y(e\))h(The)g(4)g(p)q(osition)g(should)h(ha)o(v)o(e)e(a)h
  624. (substituen)o(t)g(other)g(than)h(H,)e(and)h(a)g(v)o(ery)f(large)h(v)m(ariet)o
  625. (y)f(of)h(sub-)90 1937 y(stituen)o(ts)11 b(are)h(suitable.)19
  626. b(The)11 b(substituien)o(t)g(at)h(this)f(p)q(osition)i(is)e(critical)f(to)i
  627. (b)q(oth)g(the)g(quan)o(titativ)o(e)90 1997 y(and)g(qualitativ)o(e)e(prop)q
  628. (erties)h(of)h(the)f(comp)q(ound.)19 b(Electro-negativ)o(e)10
  629. b(groups)j(at)e(this)h(p)q(osition)g(ma)o(y)90 2057 y(enhance)k(p)q(otency)l
  630. (.)0 2152 y Fd(A)j(Theory)f(of)h(Structure)f(Activit)n(y)f(Relationships:)73
  631. 2248 y Fk(Belo)o(w)11 b(is)i(a)f(discussion)h(of)f(a)h(sp)q(eculativ)o(e)e
  632. (theory)h(of)h(\\what)g(they)f(do",)h(re\015ecting)f(on)g(the)g(structure)0
  633. 2308 y(activit)o(y)k(observ)m(ations)i(summarized)d(ab)q(o)o(v)o(e.)24
  634. b(The)18 b(theory)f(will)g(b)q(e)g(based)h(on)g(sev)o(eral)f(assumptions,)0
  635. 2368 y(whic)o(h)f(are)g(certainly)f(not)h(em)o(braced)f(b)o(y)g(Sh)o(ulgin.)
  636. 21 b(These)16 b(assumptions)g(are)h(the)f(follo)o(wing:)0 2459
  637. y(a\))h(The)f(material)e(is)i(activ)o(e)f(in)h(its)g(original,)g(un-metab)q
  638. (olized)f(form.)0 2519 y(b\))24 b(The)f(p)q(otency)h(of)g(a)g(material)e(is)h
  639. (prop)q(ortional)i(to)f(its)f(binding)h(a\016nit)o(y)e(at)i(neurotransmitter)
  640. 90 2580 y(receptors)16 b(in)g(the)g(cen)o(tral)f(nerv)o(ous)h(system)f
  641. (\(CNS\).)0 2640 y(c\))h(The)g(duration)h(of)g(a)f(material)f(is)h(in)o(v)o
  642. (ersely)d(prop)q(ortional)18 b(to)e(its)g(rate)h(of)f(metab)q(olism.)0
  643. 2700 y(d\))22 b(The)h(qualitativ)o(e)e(prop)q(erties)h(of)h(a)g(material)d
  644. (dep)q(end)j(on)f(whic)o(h)g(suite)g(of)h(CNS)f(receptors)g(the)963
  645. 2825 y(8)p eop
  646. %%Page: 9 9
  647. bop 90 50 a Fk(material)14 b(binds)j(to.)73 140 y(Consider)f(that)f(the)g(h)o
  648. (uman)g(brain)g(\(lik)o(e)e(other)j(brains\))f(sho)o(ws)h(v)o(ery)e(elab)q
  649. (orate)i(ph)o(ysical)e(sp)q(ecial-)0 201 y(ization,)f(in)g(the)h(sense)f
  650. (that)h(sp)q(eci\014c)f(neurons)h(or)g(groups)g(of)g(neurons)g(p)q(erform)e
  651. (sp)q(ecialized)g(functions.)0 261 y(This)17 b(is)g(nicely)f(illustrated)g(b)
  652. o(y)g(the)h(mapping)g(of)g(sensory)g(neurons)h(on)o(to)g(the)f(neo)q(cortex.)
  653. 23 b(In)17 b(the)g(so-)0 321 y(matosensory)j(cortex,)f(eac)o(h)h(p)q(oin)o(t)
  654. g(on)g(the)g(surface)f(of)h(the)g(skin)g(maps)f(to)h(a)g(p)q(oin)o(t)g(on)g
  655. (the)g(surface)0 381 y(of)e(the)f(cortex,)g(and)h(adjacen)o(t)g(p)q(oin)o(ts)
  656. f(on)h(the)g(skin)f(map)g(to)h(adjacen)o(t)f(p)q(oin)o(ts)h(on)g(the)f
  657. (cortex.)25 b(Th)o(us)0 441 y(there)16 b(exist)f(illustrations)h(of)g(this)h
  658. (mapping)e(in)h(whic)o(h)g(a)g(hom)o(unculus)f(is)h(dra)o(wn)h(across)g(the)f
  659. (cortex.)73 532 y(Similarly)l(,)h(sp)q(ecialized)g(language)k(functions)e
  660. (map)f(to)i(sp)q(eci\014c)e(regions)i(of)f(the)g(cortex:)27
  661. b(Bro)q(ca's)0 592 y(area,)15 b(W)l(ernic)o(k)o(e's)c(area,)k(the)f(arcuate)g
  662. (fasciculus)g(and)g(the)g(angular)h(gyrus.)21 b(While)13 b(few)h(ha)o(v)o(e)g
  663. (actually)0 652 y(b)q(een)20 b(mapp)q(ed,)g(it)g(is)g(reasonable)g(to)h(exp)q
  664. (ect)e(that)i(a)f(wide)g(v)m(ariet)o(y)f(of)h(uniquely)f(h)o(uman)g
  665. (functions)0 712 y(ha)o(v)o(e)c(sp)q(eciaized,)g(lo)q(calized)g(ph)o(ysical)h
  666. (substrates)h(in)f(the)g(brain.)73 803 y(The)22 b(sp)q(ecialization)e(of)i
  667. (regions)f(of)h(the)f(brain)g(can)h(manifest)e(itself)g(in)h(man)o(y)f(w)o(a)
  668. o(ys.)36 b(There)21 b(is)0 863 y(evidence)11 b(that)i(m)o(uc)o(h)d(of)j(the)f
  669. (neo)q(cortex)h(is)f(uniform)f(in)i(that)g(lo)q(cally)e(it)i(has)g(but)g(one)
  670. f(kind)g(of)h(circuitry)l(,)0 923 y(and)k(the)f(sp)q(ecializations)g(of)h
  671. (function)f(deriv)o(e)f(from)h(sp)q(ecialization)f(of)i(inputs)g(and)g
  672. (outputs.)23 b(In)16 b(this)0 983 y(view,)k(the)g(auditory)g(and)h(visual)f
  673. (cortex)g(are)g(structurally)f(the)h(same)f(but)i(di\013er)f(primarily)d(in)j
  674. (the)0 1044 y(sensory)d(mo)q(dalit)o(y)d(of)j(their)e(inputs.)73
  675. 1134 y(Ho)o(w)o(ev)o(er,)g(at)j(a)g(\014ner)f(scale,)g(sp)q(ecializations)f
  676. (of)i(sp)q(eci\014c)e(neurons)i(ma)o(y)e(b)q(e)h(rev)o(ealed)f(b)o(y)h(c)o
  677. (harac-)0 1194 y(teristic)g(morphologies,)h(c)o(haracteristic)e(\014ring)j
  678. (patters)f(\(e.g.,)g(burst)o(y)g(or)g(not\),)h(or)g(in)f(the)g(c)o(hemistry)0
  679. 1255 y(of)f(the)g(transmitters)e(they)h(release)g(or)i(resp)q(ond)f(to.)24
  680. b(It)16 b(is)h(the)f(c)o(hemical)e(sp)q(ecialization)i(that)h(will)f(b)q(e)0
  681. 1315 y(the)g(fo)q(cus)h(here.)73 1405 y(It)e(is)g(probably)h(safe)f(to)h(sa)o
  682. (y)f(that)h(in)f(terms)f(of)i(gross)g(morphological)f(features,)g(the)g(h)o
  683. (uman)f(brain)0 1465 y(sho)o(ws)20 b(the)g(greatest)g(lev)o(el)d(of)j
  684. (complexit)o(y)c(and)k(sp)q(ecialization)f(of)h(kno)o(wn)g(brains.)31
  685. b(It)19 b(seems)g(lik)o(ely)0 1526 y(that)f(this)f(observ)m(ation)g(could)g
  686. (generalize)f(to)i(the)f(lev)o(el)e(of)i(c)o(hemical)d(di\013eren)o(tiation)i
  687. (as)i(w)o(ell.)k(What)0 1586 y(is)15 b(b)q(eing)g(suggested)h(is)e(that)i
  688. (the)f(h)o(uman)e(brain)j(ma)o(y)d(w)o(ell)h(ha)o(v)o(e)g(a)h(more)f(div)o
  689. (erse)f(system)h(of)h(c)o(hemical)0 1646 y(comm)o(unic)o(ation)j(than)i(the)g
  690. (brains)g(of)h(an)o(y)f(other)g(sp)q(ecies.)32 b(It)19 b(seems)g(plausible)g
  691. (as)i(w)o(ell,)e(that)h(an)o(y)0 1706 y(c)o(hemical)14 b(comm)o(uni)o(cation)
  692. g(systems)i(that)h(are)g(uniquely)f(h)o(uman,)f(are)i(lik)o(ely)d(to)j(b)q(e)
  693. g(asso)q(ciated)h(with)0 1766 y(men)o(tal)c(functions)j(that)f(are)g
  694. (uniquely)f(h)o(uman.)73 1857 y(Chemical)c(di\013eren)o(tiation)h(can)h(b)q
  695. (e)h(expressed)e(in)h(a)g(v)m(ariet)o(y)f(of)i(w)o(a)o(ys,)f(but)g(those)g
  696. (that)h(are)f(relev)m(an)o(t)0 1917 y(to)j(this)g(discussion)f(are)h(the)f
  697. (di\013eren)o(tiation)g(of)h(transmitter)e(substances)j(and)f(receptors.)k
  698. (If)c(w)o(e)f(w)o(ere)0 1977 y(to)f(visualize)e(all)h(cells)g(of)h(the)f
  699. (brain)h(whic)o(h)f(utilize)f(a)i(sp)q(eci\014c)f(receptor)g(or)h
  700. (transmitter,)e(w)o(e)i(w)o(ould)f(see)0 2037 y(some)i(kind)h(of)h(a)f
  701. (functional)g(unit,)g(whic)o(h)f(conceiv)m(ably)g(ma)o(y)g(ha)o(v)o(e)h(a)g
  702. (p)q(eculiar)g(top)q(ology)h(that)g(w)o(ould)0 2098 y(mak)o(e)d(it)i
  703. (otherwise)g(hard)h(to)g(recognize)e(as)i(an)g(anatomical)e(unit.)73
  704. 2188 y(F)l(or)d(example,)e(these)h(cells)f(could)i(o)q(ccur)g(together)f(in)h
  705. (a)g(clump)d(or)j(tigh)o(tly)f(link)o(ed)f(net)o(w)o(ork,)h(thereb)o(y)0
  706. 2248 y(forming)i(a)h(clearly)f(de\014ned)h(anatomical)f(structure.)20
  707. b(Alternativ)o(ely)11 b(they)i(could)h(b)q(e)g(widely)f(disp)q(ersed)0
  708. 2309 y(through)23 b(the)f(brain)h(so)g(that)f(a)h(visualization)f(of)g(these)
  709. g(cells)f(alone)i(w)o(ould)f(tak)o(e)g(the)g(form)f(of)i(an)0
  710. 2369 y(extremely)11 b(thin)i(arra)o(y)h(sparsely)g(p)q(ermeating)f(the)g(v)o
  711. (olume)f(of)i(the)g(brain;)g(and)g(conceiv)m(ably)f(these)h(cell)0
  712. 2429 y(migh)o(t)h(mak)o(e)f(no)j(con)o(tacts)f(among)g(themselv)o(es,)d(th)o
  713. (us)j(not)h(forming)e(a)i(net)o(w)o(ork)f(on)g(their)g(o)o(wn.)73
  714. 2519 y(Regardless)j(of)h(the)e(degree)h(of)g(anatomical)f(cohesion)i(of)f
  715. (these)g(c)o(hemical)o(ly)d(de\014ned)j(structures,)0 2580
  716. y(it)f(is)g(lik)o(ely)e(that)i(in)g(man)o(y)f(if)h(not)h(most)e(cases,)i(all)
  717. e(cells)g(that)i(utilize)d(a)j(common)d(c)o(hemical)f(system)0
  718. 2640 y(represen)o(t)j(some)f(kind)i(of)g(functional)f(unit.)28
  719. b(Th)o(us)19 b(c)o(hemistry)d(pro)o(vides)i(an)h(alternativ)o(e)f(metho)q(d)g
  720. (of)0 2700 y(dissecting)11 b(functional)h(units)g(in)f(the)h(brain.)20
  721. b(Chemical)10 b(de\014nition)h(can)h(conceiv)m(ably)f(rev)o(eal)f(functional)
  722. 963 2825 y(9)p eop
  723. %%Page: 10 10
  724. bop 0 50 a Fk(structures)16 b(that)h(w)o(ould)f(b)q(e)g(virtually)f(imp)q
  725. (ossible)g(to)i(recognize)e(through)i(anatomical)e(studies.)73
  726. 140 y(Chemical)i(dissection)i(has)h(the)f(rather)h(unique)e(adv)m(an)o(tage)j
  727. (that)f(through)g(the)f(use)g(of)h(drugs,)g(it)0 201 y(is)i(p)q(ossible)h(to)
  728. g(temp)q(orarily)e(alter)h(the)h(activit)o(y)e(of)i(a)g(c)o(hemical)c(unit)j
  729. (in)h(an)g(in)o(tact)f(living)f(brain,)0 261 y(h)o(uman)d(or)i(not.)31
  730. b(In)19 b(addition,)g(the)h(ph)o(ysical)e(structure)h(of)g(these)g(c)o
  731. (hemical)e(units)i(can)g(b)q(e)h(mapp)q(ed)0 321 y(b)o(y)14
  732. b(the)h(examination)f(of)h(the)g(brains)g(of)g(cada)o(v)o(ers.)21
  733. b(Th)o(us)15 b(b)o(y)f(the)h(com)o(bination)e(of)j(ph)o(ysical)e(mapping)0
  734. 381 y(of)20 b(receptor)f(distribution)g(and)i(the)e(administration)g(of)h
  735. (receptor)f(sp)q(eci\014c)g(drugs,)i(it)e(is)h(p)q(ossible)g(to)0
  736. 441 y(asso)q(ciate)h(ph)o(ysical)e(c)o(hemical)e(units)j(with)h(their)e
  737. (functional)h(signi\014cance)g(through)h(observ)m(ation)g(of)0
  738. 501 y(the)16 b(sub)s(jectiv)o(e)e(e\013ects)i(of)h(alterations)f(in)g(the)g
  739. (activit)o(y)f(of)h(those)h(units.)73 592 y(If)f(it)g(is)g(true)g(that)h
  740. (there)e(are)i(c)o(hemical)c(systems)i(that)i(are)f(uniquely)f(h)o(uman,)g
  741. (and)h(that)h(they)f(are)0 652 y(asso)q(ciated)j(with)f(uniquely)e(h)o(uman)h
  742. (men)o(tal)f(function,)h(then)h(iden)o(ti\014cation)f(of)h(drugs)h(that)f(in)
  743. o(teract)0 712 y(with)23 b(those)g(unique)g(c)o(hemical)d(systems)i(w)o(ould)
  744. h(facilitate)e(understanding)j(of)g(those)f(systems.)40 b(It)0
  745. 773 y(w)o(ould)18 b(app)q(ear)h(that)f(pheneth)o(ylamines)d(ma)o(y)h(b)q(e)i
  746. (suc)o(h)f(to)q(ols.)27 b(A)17 b(most)g(in)o(teresting)g(asp)q(ect)h(of)g
  747. (these)0 833 y(drugs,)g(as)g(rev)o(ealed)d(through)k(the)e(w)o(ork)g(of)h
  748. (the)f(Sh)o(ulgins,)f(is)h(their)g(div)o(ersit)o(y)e(of)j(action.)24
  749. b(It)17 b(app)q(ears)0 893 y(that)d(h)o(uman)e(sub)s(jects)h(can)g
  750. (discriminate)e(dozens)j(if)e(not)i(h)o(undreds)f(of)h(pheneth)o(ylamine)c
  751. (comp)q(ounds.)0 953 y(Th)o(us)k(these)g(comp)q(ounds)g(m)o(ust)e(in)o
  752. (teract)h(di\013eren)o(tially)e(with)j(a)g(considerable)g(n)o(um)o(b)q(er)e
  753. (of)i(underlying)0 1013 y(c)o(hemical)f(functional)j(units)g(in)g(the)g(h)o
  754. (uman)f(brain.)73 1104 y(The)h(div)o(erse)e(to)q(ol)i(kit)f(of)h(pheneth)o
  755. (ylamines)c(dev)o(elop)q(ed)j(b)o(y)g(the)g(Sh)o(ulgins)g(can)h(b)q(e)g(used)
  756. f(to)h(rev)o(eal)0 1164 y(and)22 b(explore)f(the)g(functional)h
  757. (signi\014cance)f(of)h(those)g(v)m(arious)g(c)o(hemical)c(units)k(that)g
  758. (they)f(in)o(teract)0 1224 y(with.)35 b(The)20 b(apparen)o(t)h(abilit)o(y)f
  759. (of)h(h)o(umans)f(to)h(distinguish)g(qualitativ)o(e)e(di\013erences)g(b)q(et)
  760. o(w)o(een)h(suc)o(h)0 1284 y(a)e(large)f(n)o(um)o(b)q(er)f(of)i(pheneth)o
  761. (ylamines,)d(pro)o(vides)i(circumstan)o(tial)d(evidence)i(for)i(the)f
  762. (existance)g(of)h(a)0 1345 y(great)c(div)o(ersit)o(y)e(of)i(c)o(hemic)o(al)d
  763. (comm)o(unicati)o(on)h(systems)g(in)h(the)h(brain.)20 b(The)14
  764. b(apparen)o(t)g(lac)o(k)f(of)h(abilit)o(y)0 1405 y(of)f(ro)q(den)o(ts)g(to)g
  765. (discriminate)e(these)h(same)g(materials,)f(suggests)j(that)g(some)d(of)i
  766. (this)g(apparen)o(t)g(c)o(hemical)0 1465 y(div)o(ersi\014cation)i(ma)o(y)g(b)
  767. q(e)h(uniquely)f(h)o(uman.)0 1555 y Fd(Some)i(F)-5 b(urther)19
  768. b(Sp)r(eculations:)73 1646 y Fk(One)h(of)h(the)f(most)f(in)o(triguing)h(asp)q
  769. (ects)h(of)f(the)g(data)h(presen)o(ted)f(in)g(Sh)o(ulgin)g(&)g(Sh)o(ulgin)g
  770. (\(1991\))0 1706 y(is)k(the)f(\\magic)h(of)g(the)f(4-p)q(osition".)47
  771. b(If)23 b(w)o(e)h(tak)o(e)f(2,5)h(or)h(2,6)f(-)g(dimetho)o(xy)e(pheneth)o
  772. (ylamine)f(or)0 1766 y(phen)o(ylisoprop)o(ylamine,)e(and)i(pla)o(y)g(with)f
  773. (the)h(4-p)q(osition,)i(w)o(e)e(get)g(a)g(wide)g(v)m(ariet)o(y)f(of)h(comp)q
  774. (ounds)0 1827 y(with)16 b(distinct)g(e\013ects.)k(One)c(p)q(ossible)h
  775. (explanation)f(of)h(this)f(data)h(w)o(ould)f(b)q(e)g(the)g(follo)o(wing:)73
  776. 1917 y(The)23 b(family)d(of)j(receptor)f(sites)g(to)h(whic)o(h)f(the)g
  777. (pheneth)o(ylamines)e(bind)j(ha)o(v)o(e)e(ev)o(olv)o(ed)g(from)h(a)0
  778. 1977 y(common)14 b(ancestral)i(receptor)f(structure.)21 b(Some)15
  779. b(regions)h(of)g(the)g(binding)f(site)h(ha)o(v)o(e)f(b)q(een)h(conserv)o(ed)0
  780. 2037 y(in)g(this)g(ev)o(olution,)f(and)h(others)h(ha)o(v)o(e)e(v)m(aried.)21
  781. b(The)16 b(region)g(of)h(the)e(binding)h(site)g(that)h(has)f(v)m(aried)g(the)
  782. 0 2098 y(most,)j(aligns)h(with)f(the)g(4-p)q(osition)i(of)f(the)f(pheneth)o
  783. (ylamine)d(during)k(binding.)31 b(The)19 b(remainder)f(of)0
  784. 2158 y(the)f(receptor)g(binding)g(site)g(has)h(b)q(een)f(relativ)o(ely)e
  785. (conserv)o(ed)h(in)h(ev)o(olution,)g(and)h(mak)o(es)d(the)i(b)q(est)h(\014t)0
  786. 2218 y(to)f(the)f(2,5)g(or)h(2,6)f(-)h(dimetho)o(xy)d(pheneth)o(ylamine)f(or)
  787. k(phen)o(ylisoprop)o(ylamine)c(structure.)73 2309 y(It)18 b(has)g(also)h(b)q
  788. (een)f(noted)g(that)g(alkylthio)f(phen)o(ylisoprop)o(ylamines)e(sho)o(w)k(a)f
  789. (lot)g(of)g(v)m(ariabilit)o(y)f(of)0 2369 y(e\013ects)g(b)q(et)o(w)o(een)f
  790. (individuals.)24 b(This)17 b(suggests)i(that)e(there)g(is)g(genetic)g(v)m
  791. (ariation)g(within)g(the)g(h)o(uman)0 2429 y(p)q(opulation)e(for)g(the)f(sp)q
  792. (eci\014c)g(receptor)g(classes)g(that)h(b)q(est)f(bind)h(these)f(comp)q
  793. (ounds.)20 b(These)15 b(are)f(fairly)0 2489 y(wild)i(sp)q(eculations)h(at)f
  794. (this)h(p)q(oin)o(t.)k(But)16 b(they)g(ha)o(v)o(e)g(the)g(merit)e(that)j
  795. (they)f(can)h(ev)o(en)o(tually)d(b)q(e)i(tested)0 2549 y(when)g(the)g
  796. (catalog)h(of)g(h)o(uman)e(receptor)h(t)o(yp)q(es)g(b)q(ecomes)f(a)o(v)m
  797. (ailable)g(for)i(study)l(.)73 2640 y(I)e(w)o(ould)g(lik)o(e)e(to)i(mak)o(e)e
  798. (an)i(additional)g(p)q(oin)o(t)g(here,)f(ab)q(out)j(the)d(exploration)h(of)g
  799. (qualitativ)o(e)e(v)m(aria-)0 2700 y(tions.)21 b(It)13 b(can)h(b)q(e)f
  800. (tempting)f(to)i(pursue)g(comp)q(ounds)g(that)g(mak)o(e)e(one)h(feel)g(go)q
  801. (o)q(d.)22 b(These)14 b(are)f(certainly)951 2825 y(10)p eop
  802. %%Page: 11 11
  803. bop 0 50 a Fk(the)22 b(ones)i(that)f(are)g(lik)o(ely)d(to)j(get)g(the)f(most)
  804. g(use.)41 b(Ho)o(w)o(ev)o(er,)22 b(one)h(of)g(the)f(ob)s(jectiv)o(es)f(of)i
  805. (psyc)o(hic)0 110 y(exploration)d(is)g(to)h(b)q(ecome)e(more)g(familiar)f
  806. (with)j(the)f(comp)q(onen)o(ts)g(of)g(the)g(psyc)o(he,)g(b)q(oth)i(p)q
  807. (ositiv)o(e)0 170 y(and)e(negativ)o(e.)31 b(It)20 b(app)q(ears)h(that)f(Sh)o
  808. (ulgin)f(&)h(Sh)o(ulgin)f(\(1991\))i(ha)o(v)o(e)e(b)q(een)h(fairly)f(un)o
  809. (biased)h(in)f(this)0 230 y(resp)q(ect.)h(He)15 b(describ)q(es)f(Aleph-1)h
  810. (as)h(pro)q(ducing)f(\\the)h(most)e(delicious)g(blends)g(of)i(in\015ation,)f
  811. (paranoia)0 291 y(and)i(sel\014shness")g(\(p.)k(80\).)h(Ab)q(out)17
  812. b(2C-E)g(he)f(said)h(\(p.)k(518\):)122 436 y(Sev)o(eral)16
  813. b(p)q(eople)h(ha)o(v)o(e)f(said,)h(ab)q(out)i(2C-E,)f(\\I)f(don't)g(think)g
  814. (I)f(lik)o(e)g(it,)g(since)g(it)h(isn't)g(that)122 496 y(m)o(uc)o(h)k(fun.)43
  815. b(But)23 b(I)g(in)o(tend)f(to)i(explore)f(it)f(again".)44 b(There)23
  816. b(is)g(something)g(here)g(that)122 556 y(will)18 b(rew)o(ard)i(the)f(exp)q
  817. (erimen)o(ter.)o(..)o(.)28 b(let)19 b(it)g(rest)g(as)h(b)q(eing)g(a)f
  818. (di\016cult)f(and)i(w)o(orth-while)122 616 y(material.)f(A)d(v)o(ery)f(m)o
  819. (uc)o(h)f(w)o(orth-while)i(material.)73 762 y(P)o(erhaps)24
  820. b(the)g(most)f(negativ)o(e)g(comp)q(ound)g(explored)g(is)h(TMA.)f(The)h
  821. (original)f(publication)h(on)0 822 y(TMA,)15 b(Sh)o(ulgin,)h(Bunnell)e(and)j
  822. (Sargen)o(t)g(\(1961\))h(pro)o(vides)d(this)h(description:)122
  823. 967 y(The)f(emotional)e(resp)q(onses)i(elicited)e(during)h(the)h(p)q(erio)q
  824. (d)g(of)g(maxim)n(um)o(..)o(.)j(in)o(to)o(xication...)122 1027
  825. y(w)o(ere)k(striking)g(in)g(their)g(in)o(tensit)o(y)l(.)39
  826. b(Anger,)24 b(hostilit)o(y)l(,)e(and)h(megalomaniac)e(euphoria)122
  827. 1088 y(dominated)13 b(the)h(sub)s(ject's)f(though)o(ts)j(and)e(con)o(v)o
  828. (ersation.)20 b(Actual)14 b(acts)g(of)h(hostilit)o(y)e(w)o(ere)122
  829. 1148 y(not)20 b(observ)o(ed,)g(but)h(it)e(w)o(as)i(felt)e(that,)i(in)e(at)i
  830. (least)f(t)o(w)o(o)g(sub)s(jects,)g(pro)o(v)o(o)q(cation)g(w)o(ould)122
  831. 1208 y(ha)o(v)o(e)15 b(precipitated)g(homicidal)g(violence.)73
  832. 1353 y(I)j(ha)o(v)o(e)f(already)h(quoted)g(from)f(Sh)o(ulgin)g(&)h(Sh)o
  833. (ulgin)g(\(1991\))h(\(p.)27 b(24\))19 b(where)f(Sh)o(ulgin)f(p)q(oin)o(ts)i
  834. (out)0 1413 y(that)j(the)g(anger)h(of)f(TMA)g(and)g(the)g(b)q(eaut)o(y)g(of)h
  835. (mescaline)c(are)j(not)h(pro)q(ducts)g(of)f(the)g(drugs,)i(but)0
  836. 1474 y(di\013eren)o(t)15 b(asp)q(ects)i(of)g(the)f(same)f(unconscious,)h(op)q
  837. (ened)h(up)g(b)o(y)e(the)h(drugs.)73 1565 y(Finally)l(,)c(it)g(is)h(in)o
  838. (teresting)e(to)i(w)o(onder)g(at)g(the)g(\(ev)o(olutionary\))f(reasons)h(for)
  839. h(the)e(apparen)o(t)h(c)o(hemical)0 1625 y(div)o(ersit)o(y)f(of)j(the)f
  840. (brain.)20 b(The)15 b(n)o(um)o(b)q(er)d(of)j(kno)o(wn)f(neurotransmitters)f
  841. (is)h(in)g(the)g(dozens)h(and)f(gro)o(wing)0 1685 y(rapidly)l(.)20
  842. b(F)l(or)c(eac)o(h)f(of)h(the)f(b)q(etter)g(studied)g(neurotransmitters,)g
  843. (there)g(are)g(sev)o(eral)f(kno)o(wn)i(classes)g(of)0 1746
  844. y(receptors.)27 b(Wh)o(y)17 b(do)q(es)i(the)f(brain)h(need)e(more)g(than)i(t)
  845. o(w)o(o)f(c)o(hemical)d(comm)o(unic)o(ation)h(systems:)24 b(one)0
  846. 1806 y(excitatory)l(,)17 b(and)i(one)f(inhibitory)f(\(whic)o(h)h(could)f(b)q
  847. (e)i(accomplished)d(with)i(a)g(single)g(transmitter)e(and)0
  848. 1866 y(t)o(w)o(o)g(receptors\)?)21 b(And)16 b(wh)o(y)g(do)q(es)h(the)f(brain)
  849. h(need)f(m)o(ultiple)d(receptors)j(for)g(eac)o(h)g(transmitter?)73
  850. 1957 y(The)j(c)o(hemical)c(div)o(ersit)o(y)i(suggests)j(that)f(patterns)g(of)
  851. f(in)o(terconnections)g(alone)h(are)f(not)h(enough)0 2017 y(to)14
  852. b(meet)e(the)h(information)g(pro)q(cessing)i(needs)e(of)h(the)g(brain.)20
  853. b(Di\013eren)o(t)13 b(c)o(hemical)e(systems)h(m)o(ust)h(ha)o(v)o(e)0
  854. 2078 y(di\013eren)o(t)k(information)h(transmission)f(prop)q(erties.)28
  855. b(In)18 b(addition,)g(there)g(ma)o(y)f(b)q(e)h(means)g(of)g(globally)0
  856. 2138 y(a\013ecting)d(the)g(activit)o(y)e(of)i(whole)g(systems)e(of)j(neurons)
  857. f(that)g(use)g(a)h(common)c(c)o(hemical)g(messenger)i(or)0
  858. 2198 y(receptor.)951 2825 y(11)p eop
  859. %%Page: 12 12
  860. bop 631 50 a Fm(A)28 b(New)f(V)-7 b(o)r(cabulary)640 110 y
  861. Fj(A)23 b(Review)e(of)i(PIHKAL)122 256 y Fk(\\Gusta)o(v)18
  862. b(tends)f(to)g(sneer,)g(but)g(Saure)g([Bummer])c(really)j(turns)i(out)f(to)h
  863. (b)q(e)f(an)g(adept)h(at)122 316 y(the)f(di\016cult)e(art)j(of)f(pap)o
  864. (yromancy)l(,)f(the)h(abilit)o(y)e(to)j(prophesy)f(through)h(con)o
  865. (templating)122 376 y(the)c(w)o(a)o(y)f(p)q(eople)h(roll)f(reefers)g(-)h(the)
  866. g(shap)q(e,)h(the)f(lic)o(king)e(pattern,)i(the)f(wrinkles)g(and)i(folds)122
  867. 437 y(or)k(absence)f(thereof)g(in)h(the)f(pap)q(er.)28 b(`Y)l(ou)19
  868. b(will)e(so)q(on)j(b)q(e)f(in)f(lo)o(v)o(e,')f(sez)h(Saure,)h(`see)e(this)122
  869. 497 y(line)e(here.')122 578 y(\\`It's)g(long,)i(isn't)e(it?)22
  870. b(Do)q(es)17 b(that)f(mean)g(-)g(')122 659 y(\\`Length)h(is)f(usually)g(in)o
  871. (tensit)o(y)l(.)j(Not)d(time.')122 740 y(...\\`Ho)o(w)f(do)h(y)o(ou)g(lik)o
  872. (e)f(this)h(shit?')21 b(sez)16 b(Saure.)122 822 y(\\`Hubsc)o(h,')f(allo)o(ws)
  873. h(Gusta)o(v.)22 b(`A)15 b(tri\015e)h(stahlig,)g(and)h(p)q(erhaps)g(the)f
  874. (in\014nitesimal)e(hin)o(t)i(of)122 882 y(a)h(Bo)q(dengesc)o(hmac)o(k)d(b)q
  875. (ehind)i(its)g(Korp)q(er,)g(whic)o(h)g(is)g(admittedly)e(su\016g.')122
  876. 963 y(\\`I)i(w)o(ould)h(rather)f(ha)o(v)o(e)g(said)h(spritzig,')e(Saure)i
  877. (disagrees,)g(if)f(that)h(indeed)f(is)g(what)i(it)e(is.)122
  878. 1023 y(`Generally)f(more)g(buk)o(ettreic)o(h)f(than)i(last)h(y)o(ear's)e
  879. (harv)o(ests,)h(w)o(ouldn't)g(y)o(ou)g(sa)o(y?')122 1104 y(\\`Oh,)c(for)g(an)
  880. h(Haut)e(A)o(tlas)h(herbage)g(it)f(do)q(es)i(ha)o(v)o(e)e(its)g(Art,)h
  881. (Certainly)f(it)h(can)g(b)q(e)g(describ)q(ed)122 1165 y(as)h(k)o(ernig,)f(ev)
  882. o(en)g(-)h(as)g(can)g(often)g(b)q(e)g(said)f(of)h(that)h(saub)q(er)f(qualit)o
  883. (y)e(prev)m(ailing)h(in)h(the)f(Oued)122 1225 y(N\014s)k(region)g(-)h(authen)
  884. o(tically)e(pik)m(an)o(t.')122 1306 y(\\`Acutally)e(I)h(w)o(ould)g(tend)g(to)
  885. g(susp)q(ect)h(an)g(origin)f(somewhere)f(along)i(the)f(southern)h(slop)q(e)
  886. 122 1366 y(of)20 b(Jeb)q(el)f(Sarho.')32 b(Saure)19 b(sez)h(-)f(`note)h(the)f
  887. (Spiel,)g(rather)h(glatt)f(and)i(blumig,)d(ev)o(en)g(the)122
  888. 1426 y(suggestion)f(of)g(a)f(F)l(ulle)f(in)h(its)g(wurzig)g(audacit)o(y-')122
  889. 1507 y(\\`No)g(no)i(no,)e(F)l(ulle)g(is)g(o)o(v)o(erstating)g(it,)g(the)g(El)
  890. h(Abid)f(Emerald)f(w)o(e)h(had)h(last)g(mon)o(th)e(had)122
  891. 1568 y(F)l(ulle.)20 b(But)c(this)g(is)g(ob)o(viously)g(more)e(zart)j(than)g
  892. (that.')122 1649 y(\\The)g(truth)g(is)f(they)g(are)h(b)q(oth)g(so)g(blitzed)f
  893. (that)h(neither)e(one)i(kno)o(ws)g(what)g(he's)f(talking)122
  894. 1709 y(ab)q(out...")22 b(Pync)o(hon)16 b(\(1973,)h(p.)22 b(442\).)73
  895. 1855 y(The)h(b)q(o)q(ok)i(PIHKAL)e(\(Pheneth)o(ylamines)d(I)j(Ha)o(v)o(e)f
  896. (Kno)o(wn)i(And)f(Lo)o(v)o(ed\),)h(A)f(Chemical)e(Lo)o(v)o(e)0
  897. 1915 y(Story)l(,)f(is)f(un)o(usual)h(in)f(that)h(it)e(com)o(bines)g(under)h
  898. (one)h(co)o(v)o(er,)e(an)i(auto-biographical)h(no)o(v)o(el)d(ab)q(out)j(a)0
  899. 1975 y(lo)o(v)o(e)16 b(triangle,)h(and)h(30)g(y)o(ears)f(of)g(scien)o
  900. (ti\014c)f(lab)q(oratory)i(notes.)25 b(The)17 b(en)o(tire)f(pac)o(k)m(age)i
  901. (w)o(eighs)f(in)g(at)h(a)0 2036 y(heft)o(y)e(978)j(pages,)f(and)g(is)f(not)g
  902. (padded.)25 b(The)17 b(un)o(usual)h(presen)o(tation)f(is)g(a)h(re\015ection)e
  903. (of)i(the)f(sub)s(ject)0 2096 y(matter:)j(the)c(c)o(hemistry)d(of)k(the)f(h)o
  904. (uman)f(mind)g(and)i(the)f(metho)q(dology)g(of)g(its)g(exploration.)73
  905. 2187 y(I)e(consider)g(the)g(life)f(w)o(ork)h(of)h(Alexander)e(\(Sasha\))i(Sh)
  906. o(ulgin)f(to)h(represen)o(t)e(one)i(of)f(the)g(most)g(signi\014-)0
  907. 2247 y(can)o(t)d(scien)o(ti\014c)e(con)o(tributions)i(of)h(this)f(cen)o(tury)
  908. l(.)19 b(I)10 b(sa)o(y)i(this)f(b)q(ecause)g(he)g(has)h(p)q(erfected)f(a)g
  909. (metho)q(dology)0 2308 y(for)j(the)g(exploration)f(of)h(the)g(c)o(hemistry)d
  910. (of)j(the)g(h)o(uman)f(psyc)o(he,)g(and)h(he)g(has)g(used)g(that)g(metho)q
  911. (dology)0 2368 y(to)k(generate)g(a)h(large)f(set)g(of)g(c)o(hemical)d(to)q
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  914. (dology)f(violates)f(all)h(acceptable)g(scien)o(ti\014c)e(pro)q(cedures,)i
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  916. (ti\014c)f(adv)m(ance)h(that)h(Sh)o(ulgin's)e(w)o(ork)i(represen)o(ts.)19
  917. b(It)13 b(is)g(only)g(when)g(imaginativ)o(e)e(scien)o(ti\014c)0
  918. 2640 y(individuals)18 b(break)g(free)g(from)g(scien)o(ti\014c)f(traditions)i
  919. (that)g(they)g(cease)f(to)h(b)q(e)g(builders)f(and)h(b)q(ecome)0
  920. 2700 y(arc)o(hitects.)f(This)12 b(is)f(what)h(underlies)e(scien)o(ti\014c)g
  921. (rev)o(olutions.)19 b(In)11 b(spite)g(of)h(the)f(rev)o(olutionary)f(nature)i
  922. (of)951 2825 y(12)p eop
  923. %%Page: 13 13
  924. bop 0 50 a Fk(Sh)o(ulgin's)14 b(w)o(ork,)g(it)g(will)g(not)h(incite)e(a)i
  925. (scien)o(ti\014c)d(rev)o(olution)i(b)q(ecause)h(in)f(1986)i(the)e(metho)q
  926. (dology)h(w)o(as)0 110 y(prohibited)h(b)o(y)g(legislation)h(at)g(the)f
  927. (national)h(lev)o(el)e(in)h(the)h(United)e(States.)23 b(One)17
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  930. (psyc)o(hedelics)e(in)h(researc)o(h)0 230 y(or)j(therap)o(y)e(with)i(h)o
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  932. (the)h(future.)742 354 y Fj(The)22 b(Lo)n(v)n(e)i(Story)73
  933. 478 y Fk(PIHKAL)c(is)g(divided)f(roughly)h(in)g(half,)h(in)o(to)e(t)o(w)o(o)h
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  951. (w)o(ere)f(remark)m(ably)f(op)q(en.)21 b(Ho)o(w)o(ev)o(er,)11
  952. b(w)o(e)i(learn)f(more)g(ab)q(out)i(Sasha's)0 1109 y(p)q(ersonal)20
  953. b(life)e(through)i(Ann's)f(v)o(oice)f(than)i(his)f(o)o(wn.)31
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  955. 1169 y(m)o(uc)o(h)12 b(it)i(rev)o(eals)f(of)h(the)g(p)q(ersonal)h(life)e(of)i
  956. (the)f(t)o(w)o(o)g(Sh)o(ulgins.)20 b(Y)l(et)13 b(it)h(m)o(ust)f(b)q(e)h
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  960. (sex,)i(and)e(his)h(descriptions)f(of)g(drug)h(exp)q(eriences)e(tend)h(to)h
  961. (b)q(e)f(brief,)0 1378 y(clinical,)f(and)h(second)g(or)g(third)g(p)q(erson.)
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  963. 1439 y(\014rst)e(psyc)o(hedelic)d(exp)q(erience)h(\(mescaline,)g(p.)35
  964. b(16\))21 b(to)g(her)g(t)o(w)o(en)o(t)o(y)e(page)i(description)f(of)h(her)g
  965. (\014rst)0 1499 y(exp)q(erience)16 b(\(p)q(ey)o(ote,)i(p.)27
  966. b(111\).)h(While)17 b(this)h(distinction)f(in)h(their)f(writing)h(is)g
  967. (generally)f(true,)h(there)0 1559 y(are)11 b(exceptions.)19
  968. b(Sasha's)13 b(description)d(of)i(his)f(\014rst)h(2C-E)h(\(p.)19
  969. b(88\))13 b(exp)q(erience)c(is)i(impressiv)o(e)e(and)j(fairly)0
  970. 1619 y(detailed,)18 b(though)h(it)f(sounds)i(unpleasan)o(t.)28
  971. b(On)18 b(the)g(other)h(hand,)g(in)f(man)o(y)f(of)i(Ann's)f(descriptions,)0
  972. 1679 y(the)d(drug)h(exp)q(erience)d(itself)h(is)h(in)g(the)g(bac)o(kground;)h
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  974. 1740 y(and)i(is)f(not)h(presen)o(ted)f(in)g(great)g(detail.)21
  975. b(These)c(discussions)f(pro)o(vide)g(little)f(insigh)o(t)h(in)o(to)g(the)g
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  977. (ed.)73 1889 y(The)h(ideal)f(w)o(ould)h(b)q(e)g(something)e(lik)o(e)g
  978. (Naranjo)j(\(1973\),)g(whic)o(h)e(remains)f(the)i(b)q(est)g(comparativ)o(e)0
  979. 1949 y(study)22 b(of)h(psyc)o(hedelics)d(that)j(I)f(ha)o(v)o(e)f(seen.)39
  980. b(Naranjo)23 b(treats)g(four)f(comp)q(ounds)h(\(MD)o(A,)e(MMD)o(A,)0
  981. 2009 y(harmaline)10 b(and)h(ib)q(ogaine\))h(in)f(detail,)g(clearly)f(c)o
  982. (haracterizing)g(the)h(qualitativ)o(e)e(prop)q(erties)i(of)h(eac)o(h)e(and)0
  983. 2069 y(di\013eren)o(tiating)k(b)q(et)o(w)o(een)f(them.)20 b(Ho)o(w)o(ev)o
  984. (er,)12 b(he)j(dev)o(oted)f(an)h(en)o(tire)e(b)q(o)q(ok)j(to)f(these)f(four)h
  985. (comp)q(ounds.)0 2130 y(In)e(order)f(for)i(the)e(Sh)o(ulgins)h(to)g(pro)o
  986. (vide)f(equal)g(detail)g(for)h(their)g(h)o(undreds)f(of)i(comp)q(ounds,)f
  987. (they)f(w)o(ould)0 2190 y(ha)o(v)o(e)j(to)i(pro)q(duce)g(an)f(encyclop)q
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  989. 2279 y(Apart)c(from)f(pro)o(viding)h(relativ)o(ely)e(detailed)h(descriptions)
  990. g(of)i(the)f(sub)s(jectiv)o(e)e(e\013ects)i(of)g(a)h(n)o(um)o(b)q(er)0
  991. 2339 y(of)22 b(drugs)h(whose)g(e\013ects)e(ha)o(v)o(e)h(not)g(previously)f(b)
  992. q(een)h(published,)h(Bo)q(ok)f(I)g(pro)o(vides)f(a)i(v)o(ery)d(vivid)0
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  994. (these)i(materials.)38 b(W)l(e)22 b(meet)e(the)j(researc)o(h)0
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  996. (determined)c(the)j(e\013ectiv)o(e)e(dose)j(range.)33 b(They)0
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  998. (six)f(or)g(eigh)o(t.)24 b(Sasha)18 b(describ)q(es)f(what)h(he)f(kno)o(ws)h
  999. (of)0 2580 y(the)h(new)h(material)d(and)j(its)g(dose)g(range.)31
  1000. b(Eac)o(h)20 b(p)q(erson)g(c)o(ho)q(oses)g(their)f(dose,)h(and)g(the)g
  1001. (material)d(is)0 2640 y(dissolv)o(ed)g(in)g(w)o(ater)h(or)g(juice)f(and)h
  1002. (tak)o(en)g(in)f(a)h(toast.)27 b(After)17 b(the)g(exp)q(erience,)f(eac)o(h)i
  1003. (mem)n(b)q(er)d(of)j(the)0 2700 y(group)f(m)o(ust)e(submit)g(a)i(written)e
  1004. (description)h(of)g(the)g(exp)q(erience.)951 2825 y(13)p eop
  1005. %%Page: 14 14
  1006. bop 73 50 a Fk(The)20 b(selection)f(of)h(examples)e(of)i(drug)g(exp)q
  1007. (eriences)f(presen)o(ted)g(could)g(not)i(easily)e(b)q(e)h(construed)0
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  1009. b(The)23 b(examples)f(include)g(as)i(man)o(y)e(failures)g(and)0
  1010. 170 y(frigh)o(tening)e(or)h(unpleasan)o(t)g(exp)q(eriences)e(as)j
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  1013. (y)d(new)j(and)f(completely)e(unkno)o(wn)i(comp)q(ounds.)0
  1014. 291 y(The)22 b(retrosp)q(ectiv)o(e)g(of)g(thirt)o(y)g(y)o(ears)g(of)h(suc)o
  1015. (h)f(researc)o(h)g(eviden)o(tly)e(indicates)i(that)h(no)f(one)h(in)f(the)0
  1016. 351 y(researc)o(h)c(group)i(su\013ered)f(an)o(y)f(harm)g(from)g(the)g(exp)q
  1017. (erimen)o(ts.)26 b(Ho)o(w)o(ev)o(er)17 b(that)i(outcome)f(could)h(not)0
  1018. 411 y(ha)o(v)o(e)c(b)q(een)i(kno)o(wn)f(in)g(adv)m(ance.)73
  1019. 503 y(Bo)q(ok)k(I)e(describ)q(es)h(t)o(w)o(o)g(exp)q(eriences)e(in)i(whic)o
  1020. (h)f(it)h(w)o(as)h(feared)e(that)i(damage)e(migh)o(t)g(ha)o(v)o(e)g(b)q(een)0
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  1022. (t)c(in)j(whic)o(h)g(one)g(mem)o(b)q(er)d(b)q(ecame)i(essen)o(tially)0
  1023. 623 y(catatonic)24 b(for)h(the)f(duration)g(of)h(the)f(e\013ects)g(of)g(the)g
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  1025. y(among)d(the)f(other)h(mem)n(b)q(ers)d(of)j(the)g(group)g(who)h(feared)e
  1026. (that)h(the)f(state)h(ma)o(y)e(ha)o(v)o(e)h(b)q(een)h(caused)0
  1027. 743 y(b)o(y)15 b(neurological)g(damage)g(from)g(this)g(new)g(and)h(essen)o
  1028. (tially)e(unkno)o(wn)i(comp)q(ound.)21 b(Ho)o(w)o(ev)o(er,)13
  1029. b(as)j(the)0 804 y(e\013ects)i(of)g(the)f(drug)i(w)o(ore)f(o\013,)g(the)g
  1030. (catatonic)g(individual)f(regained)h(resp)q(onsiv)o(eness,)f(and)i(rep)q
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  1032. b(b)q(eautiful,...)h(an)23 b(extraordinary)h(exp)q(erience,..)o(.)40
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  1047. (susceptible)g(to)g(this)h(kind)0 1437 y(of)c(eviden)o(tly)d(uncon)o(trolled)
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  1059. (compan)o(y)g(to)h(b)q(ecome)e(a)i(free-lance)f(c)o(hemist-consultan)o(t.)36
  1060. b(He)21 b(is)h(an)0 1890 y(analytical)d(c)o(hemist)d(with)k(a)f(federal)g
  1061. (license)f(to)h(w)o(ork)h(with)f(all)g(sc)o(heduled)f(drugs.)31
  1062. b(His)19 b(consultan)o(t)0 1950 y(w)o(ork)d(includes)f(serving)h(as)h(a)g
  1063. (witness)f(in)g(court)g(cases)h(concering)f(drugs.)73 2042
  1064. y(In)g(addition)g(to)g(his)g(decision)g(to)g(lea)o(v)o(e)e(the)i(compan)o(y)f
  1065. (and)h(b)q(ecome)f(indep)q(enden)o(t,)g(he)h(also)g(made)0
  1066. 2102 y(a)23 b(decision)f(not)i(to)f(tak)o(e)f(his)h(w)o(ork)f(underground.)42
  1067. b(He)22 b(has)i(con)o(tin)o(ued)e(to)h(publish)f(m)o(uc)o(h)f(of)i(his)0
  1068. 2162 y(w)o(ork)15 b(o)o(v)o(er)e(the)h(y)o(ears)h(in)f(v)m(arious)h(scien)o
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  1080. eop
  1081. %%Page: 15 15
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  1151. %%Page: 16 16
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  1227. %%Page: 17 17
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  1237. (the)h(men)o(tal)90 351 y(e\013ects.)0 411 y(A\))j(Activ)o(e:)j(clearly)c
  1238. (sho)o(ws)i(psyc)o(hedelic)d(activit)o(y)l(.)0 471 y(N\))f(Not)g(activ)o(e:)
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  1241. y(has)j(b)q(een)f(found.)0 592 y(O\))f(Other)g(than)h(psyc)o(hedelic)d
  1242. (activit)o(y:)20 b(other)15 b(than)h(psyc)o(hedelic)d(activit)o(y)h(has)i(b)q
  1243. (een)f(demonstrated.)90 652 y(These)23 b(\\other")g(activities)e(include)h
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  1245. (anorexic,)90 712 y(adrenergic)16 b(bronc)o(ho)q(dilator,)g(stim)o(ulan)o(t)e
  1246. (and)j(an)o(titussiv)o(e.)0 772 y(I\))f(Incomplete)e(syn)o(thesis:)21
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  1248. (een)f(completed,)e(th)o(us)i(the)90 832 y(\014nal)g(pheneth)o(ylamine)e(is)i
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  1250. b(unkno)o(wn:)21 b(the)15 b(comp)q(ound)h(app)q(ears)g(in)f(the)g(b)q(o)q
  1251. (ok,)h(but)g(there)e(is)h(no)h(statemen)o(t)e(as)i(to)f(the)90
  1252. 953 y(status,)i(it)e(is)i(probably)f(un)o(tested.)73 1051 y(The)h
  1253. (distinction)f(b)q(et)o(w)o(een)g(categories)h(X)g(and)g(P)h(is)e(subtle)h
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  1257. b(that)g(a)g(material)e(is)h(b)q(eliev)o(ed)f(to)i(b)q(e)g(to)o(xic,)g(and)g
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  1261. 1292 y(classi\014ed)g(as)h(P)l(.)73 1390 y(The)f(coun)o(ts)h(of)f(comp)q
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  1264. 1544 y(S\))85 b(51)51 b(Sub-threshold)98 1604 y(T\))77 b(31)51
  1265. b(Threshold)98 1664 y(X\))100 b(2)50 b(T)l(o)o(xic)98 1725
  1266. y(P\))79 b(11)51 b(Ph)o(ysical)15 b(more)g(than)i(men)o(tal)98
  1267. 1785 y(A\))51 b(107)g(Activ)o(e)98 1845 y(N\))75 b(25)51 b(Not)16
  1268. b(activ)o(e)98 1905 y(O\))99 b(8)50 b(Other)16 b(than)g(psyc)o(hedelic)e
  1269. (activit)o(y)98 1965 y(I\))119 b(2)50 b(Incomplete)13 b(syn)o(thesis)98
  1270. 2025 y(?\))114 b(3)50 b(Status)17 b(unkno)o(wn)73 2120 y(It)i(seems)g(a)h
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  1275. (ounds)h(w)o(ere)f(dev)o(elop)q(ed)g(as)h(p)q(oten)o(tial)g(brain)g(imaging)e
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  1277. (psyc)o(hedelics,)f(and)i(so)g(ha)o(v)o(e)f(not)h(b)q(een)g(tasted.)29
  1278. b(Ho)o(w)o(ev)o(er,)17 b(these)h(accoun)o(t)g(for)h(less)0
  1279. 2361 y(than)e(half)f(of)h(the)f(U)f(category)l(.)73 2459 y(What)k(is)f(the)g
  1280. (most)f(frustrating)i(is)f(the)f(S)i(category)f(\(and)h(to)f(a)h(lesser)e
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  1283. o(w)g(lev)o(els.)j(Here)0 2580 y(w)o(e)g(m)o(ust)e(recognize)i(that)g(Sasha)i
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  1285. (himself)d(b)q(efore)0 2640 y(exp)q(osing)h(other)f(h)o(umans)f(to)i(the)f
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  1287. (leads)g(to)g(the)0 2700 y(problem)e(of)h(\\so)i(man)o(y)c(pheneth)o
  1288. (ylamines,)f(so)k(little)e(time".)951 2825 y(17)p eop
  1289. %%Page: 18 18
  1290. bop 73 50 a Fk(It)17 b(app)q(ears)i(that)f(there)f(is)g(y)o(et)g(another)h
  1291. (reason)g(wh)o(y)g(man)o(y)e(comp)q(ounds)h(w)o(ere)g(only)g(titrated)h(to)0
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  1293. (ere)g(syn)o(thesized)e(as)j(v)m(ariations)g(on)f(kno)o(wn)h(activ)o(e)d
  1294. (comp)q(ounds.)0 170 y(They)18 b(w)o(ere)g(then)g(titrated)g(up)h(to)g(the)f
  1295. (lev)o(el)e(at)j(whic)o(h)f(the)g(mo)q(del)g(comp)q(ound)g(sho)o(w)o(ed)g
  1296. (activit)o(y)l(.)27 b(If)0 230 y(they)17 b(w)o(ere)h(not)g(activ)o(e)f(at)h
  1297. (that)h(lev)o(el,)c(titration)j(w)o(as)h(stopp)q(ed.)27 b(This)18
  1298. b(indicates)g(that)g(in)g(this)f(w)o(ork,)0 291 y(there)11
  1299. b(w)o(as)h(a)g(greater)f(emphasis)g(on)h(p)q(otency)g(than)g(on)g(the)f
  1300. (qualitativ)o(e)f(prop)q(erties)h(of)h(the)f(comp)q(ounds.)0
  1301. 351 y(There)h(ma)o(y)f(b)q(e)i(man)o(y)e(mescalines)f(or)j(MDMAs)f
  1302. (\(ecstacy\))g(among)h(these)f(sub-threshold)h(comp)q(ounds;)0
  1303. 411 y(materials)i(whic)o(h)g(sho)o(w)i(marv)o(elous)e(activit)o(y)f(at)j(m)o
  1304. (uc)o(h)d(higher)i(doses)h(than)g(ha)o(v)o(e)e(b)q(een)h(tested.)73
  1305. 504 y(It)21 b(w)o(ould)g(b)q(e)h(in)o(teresting)e(to)h(kno)o(w)h(the)f(dates)
  1306. g(of)h(syn)o(thesis)f(and)g(testing)h(of)f(these)g(materials.)0
  1307. 564 y(I)f(susp)q(ect)h(that)g(m)o(uc)o(h)d(of)j(the)f(earlier)f(w)o(ork)i
  1308. (placed)e(a)i(great)g(emphasis)f(on)g(p)q(otency)l(,)h(while)f(in)g(his)0
  1309. 624 y(later)d(w)o(ork,)f(he)h(has)h(sho)o(wn)g(a)f(greater)g(in)o(terest)f
  1310. (in)h(qualit)o(y)l(.)22 b(F)l(or)17 b(example,)d(the)j(2C)h(comp)q(ounds)f
  1311. (are)0 685 y(generally)c(less)h(p)q(oten)o(t)g(but)g(qualitativ)o(ely)e(b)q
  1312. (etter)i(than)h(the)e(3C)i(comp)q(ounds.)21 b(Y)l(et)13 b(m)o(uc)o(h)f(of)i
  1313. (the)g(w)o(ork)0 745 y(on)h(the)g(2C)g(comp)q(ounds)g(has)h(eviden)o(tly)c(b)
  1314. q(een)j(in)g(the)f(last)h(ten)g(y)o(ears.)20 b(Sh)o(ulgin)14
  1315. b(\(1983\))j(describ)q(es)d(this)0 805 y(c)o(hanging)j(fo)q(cus)g(in)e(his)i
  1316. (o)o(wn)f(w)o(ords:)122 962 y(Throughout)f(this)e(early)f(w)o(ork,)i(I)e(w)o
  1317. (as)i(absorb)q(ed)g(primarily)d(with)i(ho)o(w)h(m)o(uc)o(h)d(of)i(a)h(c)o
  1318. (hemi-)122 1023 y(cal)f(it)g(to)q(ok)i(to)e(ac)o(hiev)o(e)f(an)i(e\013ect,)f
  1319. (rather)h(than)g(with)f(the)g(nature)h(of)g(the)f(e\013ect)g(ac)o(hiev)o(ed.)
  1320. 122 1083 y(In)g(m)o(y)f(notes)h(the)h(term)d(\\psyc)o(hedelic)h(e\013ectiv)o
  1321. (eness")g(re\015ected)g(only)i(the)f(p)q(otency)l(.)20 b(I)13
  1322. b(left)122 1143 y(to)19 b(others)h(the)f(task)g(of)g(determining)e(the)i
  1323. (qualitativ)o(e)e(asp)q(ects)j(of)f(the)g(e\013ects)g(of)g(these)122
  1324. 1203 y(drugs,)f(and)h(their)e(p)q(oten)o(tial)g(v)m(alues.)26
  1325. b(It)18 b(w)o(as)g(around)h(this)f(time)d(that)j(I)g(b)q(ecame)e(a)o(w)o(are)
  1326. 122 1263 y(that)i(I)f(w)o(as)h(trying)f(to)h(answ)o(er)g(a)g(complex)d
  1327. (question)i(with)h(a)g(hop)q(elessly)f(restricted)f(v)o(o-)122
  1328. 1324 y(cabulary)l(....)122 1409 y(A)j(mo)q(dest)g(w)o(ealth)g(of)h(disco)o(v)
  1329. o(ery)e(in)h(sev)o(eral)f(researc)o(h)h(en)o(vironmen)o(ts)e(throughout)k
  1330. (the)122 1469 y(w)o(orld)16 b(b)q(egan)i(unco)o(v)o(ering)d(the)h(generalit)o
  1331. (y)f(of)i(psyc)o(hedelic)d(drug)j(structures)f(and,)g(m)o(uc)o(h)122
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  1335. 1675 y(Here)21 b(w)o(as)i(the)f(start)h(of)g(m)o(y)d(quest)i(of)h(caring.)40
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  1342. (little)e(merit)122 1916 y(merely)d(to)k(observ)o(e)e(what)i(a)g(drug)f(do)q
  1343. (es)h(to)g(the)f(h)o(uman)f(nerv)o(ous)h(system,)f(unless)h(one)122
  1344. 1976 y(also)14 b(observ)o(es)g(ho)o(w)g(it)g(p)q(ermits)e(a)i(p)q(erson)h(to)
  1345. f(in)o(teract)f(with)h(others,)g(and)g(esp)q(ecially)l(,)f(ho)o(w)122
  1346. 2036 y(it)j(allo)o(ws)g(him)f(to)h(ac)o(kno)o(wledge)g(himself..)o(..)122
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  1349. 2181 y(There)d(are)h(literally)e(h)o(undreds)i(of)g(psyc)o(hedelic)e
  1350. (\\catalysts")j(curren)o(tly)d(at)i(hand)h(that)f(run)122 2242
  1351. y(the)18 b(gam)o(ut)g(of)h(p)q(otencies)f(and)h(qualitativ)o(e)e(c)o
  1352. (haracteristics.)27 b(But)18 b(no)o(w)h(it)f(is)g(b)q(ecoming)122
  1353. 2302 y(apparen)o(t)24 b(to)g(me)e(that)i(these)g(materials,)f(rather)h(than)g
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  1359. y(b)q(ecause)g(they)f(w)o(ere)f(less)i(p)q(oten)o(t)f(than)h(the)g(comp)q
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  1362. (ounds:)951 2825 y(18)p eop
  1363. %%Page: 19 19
  1364. bop 73 50 a Fk(The)21 b(ideal)f(psyc)o(hedelic)e(w)o(ould)j(ha)o(v)o(e)f(its)
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  1367. (system.)42 b(Ho)o(w)o(ev)o(er,)24 b(in)f(the)h(real)f(w)o(orld,)i(an)o(y)0
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  1388. 2825 y(19)p eop
  1389. %%Page: 20 20
  1390. bop 483 50 a Fm(So)28 b(Man)n(y)e(Pheneth)n(ylamines,)677 118
  1391. y(So)i(Little)f(Time...)657 178 y Fj(A)22 b(Guide)g(to)h(PIHKAL)73
  1392. 325 y Fk(Those)c(of)f(y)o(ou)f(who)i(enjo)o(y)o(ed)d(PIHKAL)h(are)h(no)g
  1393. (doubt)h(lo)q(oking)f(forw)o(ard)g(to)g(the)g(publication)f(of)0
  1394. 385 y(TIHKAL)d(\(tryptamines)f(I)h(ha)o(v)o(e)g(kno)o(wn)g(and)h(lo)o(v)o
  1395. (ed\),)f(dealing)g(with)g(the)h(indole)e(based)i(psyc)o(hedelics.)0
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  1399. (ducing)h(some)e(in)o(teresting)g(results,)h(most)g(notoriously)0
  1400. 566 y(Imip)q(olex.)19 b(One)d(exp)q(erimen)o(tal)d(sub)s(ject)j(rep)q(orts:)
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  1403. 773 y(p)q(olymer,)g(v)o(ery)h(tigh)o(t)h(at)h(the)e(w)o(aist,)h(op)q(en)h(at)
  1404. g(the)f(crotc)o(h.)k(It)c(felt)f(aliv)o(e)g(on)i(me.)i(`F)l(orget)122
  1405. 834 y(leather,)j(forget)g(satin,')g(shiv)o(ered)e(Drohne.)38
  1406. b(`This)21 b(is)g(Imip)q(olex,)f(the)i(material)d(of)j(the)122
  1407. 894 y(future.')30 b(I)19 b(can't)g(describ)q(e)g(its)h(p)q(erfume,)e(or)i(ho)
  1408. o(w)g(it)f(felt)f(-)i(the)f(luxury)l(.)30 b(The)20 b(momen)o(t)122
  1409. 954 y(it)f(touc)o(hed)g(them)f(it)h(brough)o(t)h(m)o(y)d(nipples)i(up)g(sw)o
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  1413. 1074 y(me)c(quite)h(as)h(m)o(uc)o(h)e(as)i(Imip)q(olex.)18
  1414. b(They)12 b(promised)g(me)f(brassieres,)i(c)o(hemises,)d(sto)q(c)o(kings,)122
  1415. 1135 y(go)o(wns)18 b(of)g(the)f(same)f(material.)23 b(Drohne)18
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  1419. b(w)o(as)i(an)122 1255 y(ab)o(yss)14 b(b)q(et)o(w)o(een)g(m)o(y)e(feet.)20
  1420. b(Things,)14 b(memories,)d(no)k(w)o(a)o(y)f(to)g(distinguish)g(them)f(an)o(y)
  1421. h(more,)122 1315 y(w)o(en)o(t)d(tum)o(bling)f(do)o(wn)o(w)o(ard)i(through)h
  1422. (m)o(y)d(head.)20 b(A)12 b(torren)o(t.)19 b(I)12 b(w)o(as)g(ev)m(acuating)g
  1423. (all)g(these,)122 1375 y(out)i(in)o(to)f(some)f(v)o(oid)h(...)19
  1424. b(from)13 b(m)o(y)e(v)o(ertex,)h(curling,)h(brigh)o(t-colored)g
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  1426. b(baubles,)19 b(am)o(using)g(lines)f(of)i(dialogue,)f(ob)s(jects)g(d'art)h
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  1428. b(Holding)18 b(none.)27 b(W)l(as)19 b(this)f(`submission,')f(then)h(-)h
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  1430. b(488\).)73 1703 y(Because)17 b(PIHKAL)f(is)h(so)h(large,)f(I)g(w)o(ould)g
  1431. (lik)o(e)f(to)h(assist)h(readers)f(who)h(ha)o(v)o(e)f(less)g(time)e(to)i(in)o
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  1435. (the)g(b)q(o)q(ok:)73 1915 y(Man)o(y)h(readers)g(will)f(w)o(an)o(t)i(to)f
  1436. (kno)o(w)h(whic)o(h)e(of)i(the)f(311)h(comp)q(ounds)g(presen)o(ted)e(are)h
  1437. (the)g(\\b)q(est".)0 1975 y(Early)c(in)g(his)g(career,)g(Sasha)h
  1438. (classi\014ed)f(comp)q(ounds)g(as)h(b)q(etter)f(if)f(they)h(w)o(ere)f(more)g
  1439. (p)q(oten)o(t,)i(regardless)0 2036 y(of)20 b(their)f(qualitativ)o(e)f
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  1443. g(top)h(pheneth)o(ylamines,)c(based)15 b(on)0 2156 y(\\their)d(acceptabilit)o
  1444. (y)e(and)j(their)e(in)o(trinsic)g(ric)o(hness".)19 b(They)12
  1445. b(are:)20 b(2C-T-7,)14 b(2C-T-2,)g(2C-B,)f(mescaline)0 2216
  1446. y(and)21 b(2C-E.)f(In)o(terestingly)l(,)f(all)h(of)g(them)f(are)h(quite)f
  1447. (literally)f(pheneth)o(ylamines.)30 b(That)21 b(is,)f(none)h(of)0
  1448. 2276 y(them)f(are)h(phen)o(ylisoprop)o(ylamines.)33 b(It)21
  1449. b(is)g(not)h(clear)f(if)f(the)h(list)g(w)o(as)h(mean)o(t)e(to)h(b)q(e)h
  1450. (restricted)e(to)0 2336 y(pheneth)o(ylamines,)e(or)i(if)g(none)g(of)h(the)e
  1451. (phen)o(ylisoprop)o(ylamines)f(made)h(it)g(in)o(to)h(the)g(list)f(of)i(the)f
  1452. (top)0 2397 y(\014v)o(e.)0 2488 y Fd(Descriptions)d(of)i(Drug)g(Exp)r
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  1455. (exp)q(erience,)h(description)i(in)g Fc(<)g Fk(1)g(page,)h(actually)f(a)g
  1456. (distillation,)f(not)i(a)90 2700 y(mo)o(ving)f(description,)g(but)h(a)h
  1457. (strong)g(one.)951 2825 y(20)p eop
  1458. %%Page: 21 21
  1459. bop 0 50 a Fk(p.)20 b(22-25)15 b(TMA:)d(\\mescaline)f(no)i(more)f(pro)q
  1460. (duced)h(b)q(eaut)o(y)g(than)h(TMA)e(pro)q(duced)i(anger.)20
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  1462. (within)g(me,)g(so)h(w)o(as)g(the)f(anger.)29 b(Di\013eren)o(t)18
  1463. b(drugs)i(ma)o(y)d(sometime)o(s)f(op)q(en)90 170 y(di\013eren)o(t)f(do)q(ors)
  1464. j(in)e(a)h(p)q(erson,)f(but)h(all)e(of)i(those)g(do)q(ors)g(lead)f(out)h(of)g
  1465. (the)f(same)f(unconscious.")0 230 y(p.)27 b(34-39)20 b(MMD)o(A:)c(a)i
  1466. (description)g(of)g(the)g(exp)q(erience)e(b)o(y)i(\\a)h(p)q(o)q(et".)27
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  1468. g(uninformativ)o(e.)0 351 y(p.)33 b(51-52)23 b(MEM:)c(a)i(v)o(ery)e(p)q(o)o
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  1470. (e\013ect)h(on)h(a)g(w)o(oman)90 411 y(whom)16 b(he)g(used)g(it)g(with.)0
  1471. 471 y(p.)25 b(54-56)19 b(DOM:)d(completely)f(clinical)g(description)i(of)g
  1472. (the)g(drug,)h(except)e(for)i(a)g(three)e(line)g(quote)i(at)90
  1473. 531 y(the)e(end)g(of)h(the)f(c)o(hapter.)0 592 y(p.)27 b(69-74)20
  1474. b(MDMA:)d(the)h(description)g(of)g(therap)q(eutic)g(b)q(ene\014ts)g(are)g
  1475. (con)o(vincing)f(but)i(detac)o(hed,)e(2nd)90 652 y(p)q(erson.)0
  1476. 712 y(p.)44 b(75-79)26 b(MDOH-MD)o(A-marijuana)d(com)o(bination:)35
  1477. b(Time-Stop.)43 b(F)l(airly)23 b(detailed)g(but)h(clinical)90
  1478. 772 y(description.)d(He)15 b(w)o(as)i(frigh)o(tened,)e(sounds)i(unpleasan)o
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  1480. (t)f(tense)g(narativ)o(e,)g(the)g(written)g(notes)g(from)g(the)g(exp)q(eri-)
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  1482. (delicious)g(blends)h(of)h(in\015ation,)f(paranoia)h(and)90
  1483. 953 y(sel\014shness".)0 1013 y(p.)22 b(88-97)c(2C-E:)f(and)g(death)g(of)g
  1484. (wife.)k(This)c(section)f(is)g(written)g(with)h(a)f(great)h(deal)f(of)h
  1485. (honest)o(y)l(.)22 b(The)90 1073 y(description)16 b(of)g(2C-E)h(is)f
  1486. (impressiv)o(e)e(and)j(fairly)e(detailed,)g(but)h(sounds)i(unpleasan)o(t.)0
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  1489. b(describ)q(es)g(p)q(ey)o(ote)f(with)h(m)o(uc)o(h)d(p)q(ersonal)k(in)o
  1490. (timacy)c(&)j(detail.)28 b(20)20 b(pages!)90 1254 y(compared)15
  1491. b(to)i(his)f(1)h(page)f(distillation)g(on)g(p.)22 b(16-17.)0
  1492. 1314 y(p.)30 b(192-203)21 b(MDMA:)d(11)i(pages,)g(her)f(\014rst)g(p)q(erson)h
  1493. (presen)o(t)f(narrativ)o(e.)29 b(There)18 b(is)h(a)h(lot)e(of)i(talk)f(b)o(y)
  1494. 90 1374 y(him.)h(W)l(e)c(learn)f(more)g(ab)q(out)j(his)e(marriage)f(than)i
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  1496. b(210-217)c(Aleph-2:)j(she)17 b(didn't)f(get)h(o\013,)g(so)h(it)e(not)h(a)g
  1497. (v)o(ery)f(exciting)f(description.)23 b(But)16 b(this)h(is)f(the)90
  1498. 1494 y(\014rst)h(description)e(of)i(the)f(group.)0 1555 y(p.)23
  1499. b(219-222)d(2C-B:)d(the)f(description)h(is)f(not)i(v)o(ery)d(in)o(triguing,)h
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  1501. 1615 y(materials.)j(Sho)o(ws)d(that)f(one)h(can)f(ha)o(v)o(e)g(sex)f(with)i
  1502. (it.)0 1675 y(p.)29 b(224-229)22 b(DOM:)c(again,)i(not)g(a)f(remark)m(able)e
  1503. (drug)j(description.)29 b(The)19 b(narration)g(is)g(more)f(ab)q(out)90
  1504. 1735 y(their)e(exp)q(erimen)o(t)e(with)j(b)q(ondage.)24 b(It)17
  1505. b(o)q(ccurs)g(to)g(me)e(that)j(he)e(nev)o(er)g(discussed)h(sex)f(in)h(his)g
  1506. (o)o(wn)90 1795 y(v)o(oice,)d(but)j(she)f(do)q(es)h(a)g(lot.)0
  1507. 1856 y(p.)k(233-239)e(psilo)q(cybine:)h(not)d(a)g(pheneth)o(ylamine,)c(a)j
  1508. (decen)o(t)f(description)h(of)g(the)g(exp)q(erience.)0 1916
  1509. y(p.)21 b(248)d(MDMA:)d(used)h(to)h(defeat)f(\\Sib)q(erian)g(w)o(astelands",)
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  1514. b(283-285)e(2C-T-2:)k(a)17 b(fairly)e(shallo)o(w)h(description,)g(fo)q(cused)
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  1526. (one)h(of)g(the)f(b)q(etter)g(descriptions.)20 b(She)14 b(describ)q(es)g(an)h
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  1528. (and)i(some)e(in)o(teresting)g(imagery)l(.)20 b(They)c(ha)o(v)o(e)f(sex.)0
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  1530. (group)i(exp)q(erimen)o(t,)d(but)i(a)g(shallo)o(w)h(material.)j(One)951
  1531. 2825 y(21)p eop
  1532. %%Page: 22 22
  1533. bop 90 50 a Fk(group)17 b(mem)o(b)q(er)c(w)o(en)o(t)j(catatonic,)g(causing)g
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  1535. (description)g(of)i(the)e(exp)q(erience.)18 b(Pro)o(vided)12
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  1545. 653 y Fk(p.)44 b(75-79)26 b(MDOH-MD)o(A-marijuana)d(com)o(bination:)35
  1546. b(Time-Stop.)43 b(F)l(airly)23 b(detailed)g(but)h(clinical)90
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  1555. (yl-DMA)c(-)j(MDMA)0 1315 y(p.)k(777-778)e(Meth)o(yl-DOB)c(-)h(Psilo)q
  1556. (cybine)0 1375 y(p.)21 b(778)d(p)q(oten)o(tiation)0 1435 y(p.)j(892)d(TMPEA)e
  1557. (-)g(mescaline)0 1495 y(p.)21 b(909)d(TOMOSO)e(e\013ect,)f(more)g(metab)q
  1558. (olic)g(babble)0 1555 y(recip)q(e)g(#20)i(2C-B)g(-)f(MDMA)0
  1559. 1646 y Fd(Discussions)i(of)h(Structure)f(-)g(Activit)n(y)g(Relationships)0
  1560. 1737 y Fk(p.)23 b(53-54)18 b(discussion)f(of)g(a)g(structure)f(activit)o(y)f
  1561. (exp)q(erimen)o(t)f(in)j(whic)o(h)f(the)g(data)i(supp)q(ort)f(a)h(receptor)90
  1562. 1797 y(rather)e(than)h(metab)q(olic)e(h)o(yp)q(othesis.)0 1857
  1563. y(p.)21 b(68-69)d(the)e(quinone)g Fb(\000)e Fc(>)i Fk(indole)g(h)o(yp)q
  1564. (othesis)g(of)h(activit)o(y)l(.)0 1918 y(p.)k(83)c(RS)g Fb(\000)c
  1565. Fc(>)j Fk(HS)g(assumption)g(of)h(metab)q(olism)d(to)i(explain)g(activit)o(y)l
  1566. (.)0 1978 y(p.)21 b(356-357)e(assumption)d(of)h(activit)o(y)d(through)j
  1567. (metab)q(olism)0 2038 y(p.)k(474-475)e(Beth)d(state,)g(\\F)l(ourier)g(T)l
  1568. (ransform")g(of)h(men)o(tal)d(states)0 2098 y(p.)21 b(585)d(north)f(&)f
  1569. (south)h(end)f(of)g(receptor)0 2158 y(p.)21 b(595)d(assumption)e(of)g
  1570. (activit)o(y)f(related)g(to)i(metab)q(olism)0 2218 y(p.)k(615)d(DMPEA:)d(and)
  1571. i(the)f(\\pink)g(sp)q(ot")0 2279 y(p.)21 b(636)d(discussion)e(of)h
  1572. (sub-classes)g(of)f(5HT)h(receptors)0 2339 y(p.)k(644-646)e(h)o(ydro)q
  1573. (quinone)d(h)o(yp)q(othesis)0 2399 y(p.)21 b(680)d(assumption)e(that)g(DOM)h
  1574. (is)f(activ)o(e)e(through)k(metab)q(olites)0 2459 y(p.)j(691)d(activit)o(y)c
  1575. (through)j(metab)q(olism)0 2519 y(p.)28 b(696-697)21 b(discussion)d(of)h
  1576. (receptor)f(sub)q(classes,)h(c)o(hemical)c(classes,)k(\\what)g(are)g(they",)f
  1577. (\\where)h(do)90 2580 y(they)d(go",)h Fb(\000)c Fc(>)j Fk(\\what)i(do)f(they)
  1578. e(do")0 2640 y(p.)20 b(708)12 b(a)g(c)o(hemical)c(h)o(yp)q(othesis)j(of)h
  1579. (activit)o(y)d(through)k(metab)q(olism,)c(this)i(one)g(relates)g(to)h
  1580. (amphetamine)90 2700 y(psyc)o(hosis,)k(and)h(is)f(obsolete)g(in)g(the)g(ligh)
  1581. o(t)f(of)i(Jacob's)f(studies)951 2825 y(22)p eop
  1582. %%Page: 23 23
  1583. bop 0 50 a Fk(p.)21 b(711)d(more)d(sp)q(eculation)h(ab)q(out)i(activit)o(y)c
  1584. (requiring)h(metab)q(olism)0 110 y(p.)21 b(839-840)e(the)d(fallacy)g(of)g
  1585. (predicting)f(p)q(otency)i(b)o(y)e(structure)0 170 y(p.)21
  1586. b(909)d(TOMOSO)e(e\013ect,)f(more)g(metab)q(olic)g(babble)0
  1587. 261 y Fd(Miscellaneous:)0 353 y Fk(p.)21 b(55)c(\\rubb)o(y")g(teeth)f
  1588. (de\014ned)0 413 y(p.)21 b(60-65)d(describ)q(es)e(his)g(decision)g(to)h(do)f
  1589. (his)g(w)o(ork)h(ab)q(o)o(v)o(e)f(ground)h(rather)f(than)h(underground.)0
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  1591. (Naranjo.)0 533 y(p.)k(361)d(discussion)e(of)h(\015ash)o(bac)o(ks.)0
  1592. 593 y(p.)k(459)d(1st)f(commen)n(tary)l(,)c(crazy)j(fan)o(tasy)l(,)g(un)o
  1593. (tasted)g(material)0 654 y(p.)21 b(459,)c(750-751)i(crazy)d(logic)0
  1594. 714 y(p.)21 b(464)d(ego)e(in\015ation)h(&)f(mania,)f(c)o(h)h(14)0
  1595. 774 y(p.)21 b(466)d(high)e(v)m(ariabilit)o(y)f(of)h(S)h(amphetamines)0
  1596. 834 y(p.)k(474-475)e(Beth)d(state,)g(\\F)l(ourier)g(T)l(ransform")g(of)h(men)
  1597. o(tal)d(states)0 894 y(p.)21 b(479-480)e(ten)d(classic)g(ladies)0
  1598. 954 y(p.)21 b(486-487)e(N-meth)o(yl)14 b(not)i(go)q(o)q(d)j(\(Con)o(trary)d
  1599. (to)h(MDMA\))e(example)f(of)j(susp)q(ected)f(to)o(xicit)o(y)l(.)0
  1600. 1015 y(p.)21 b(490-492)e(examples)14 b(of)j(susp)q(ected)f(to)o(xicit)o(y)0
  1601. 1075 y(p.)21 b(494)d(BO)o(X)d(series,)g(relation)h(to)g(norepinephrine)0
  1602. 1135 y(p.)21 b(498)d(b)q(eta-ethanolamines)0 1195 y(p.)j(514)d(Tw)o(eetios)0
  1603. 1255 y(p.)j(566-567)e(pseudo)e(\\next)f(10)h(y)o(ears")f(of)h(psyc)o
  1604. (hedelics)0 1316 y(p.)k(570)d(5)e(top)h(pheneth)o(ylamines:)i(2C-T-7,)e
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  1606. (breaking")h(length)f(x)g(p)q(otency)0 1436 y(p.)21 b(588)d(most)d(p)q(oten)o
  1607. (t)i(pheneth)o(ylamine)0 1496 y(p.)k(636)d(discussion)e(of)h(sub-classes)g
  1608. (of)f(5HT)h(receptors)0 1556 y(p.)k(649)d(an)e(h)o(ypnogogic)h(comp)q(ound)0
  1609. 1617 y(p.)30 b(664-671)22 b(F-2,)e(F,)f(F-22:)28 b(these)19
  1610. b(w)o(ere)g(only)g(run)g(up)h(to)f(the)g(15)h(mg)f(range.)31
  1611. b(A)18 b(pit)o(y)l(,)h(they)g(migh)o(t)90 1677 y(sho)o(w)e(in)o(teresting)e
  1612. (activit)o(y)f(at)j(ten)f(times)e(the)i(dose.)0 1737 y(p.)21
  1613. b(673)d(HOT)e(comp)q(ounds)g(N-OH)0 1797 y(p.)29 b(676)20 b(G-4:)27
  1614. b(The)19 b(comp)q(ound)f(is)h(listed)e(ev)o(en)h(though)i(its)e(syn)o(thesis)
  1615. h(is)f(not)h(complete.)27 b(There)18 b(are)90 1857 y(other)e(examples)f(of)h
  1616. (this)g(in)g(the)g(b)q(o)q(ok.)0 1918 y(p.)21 b(676)d(\\for)f(a)f(p)q(erio)q
  1617. (d)h(of)g(time)d(\(ab)q(out)j(3)g(y)o(ears\))f(b)o(y)f(whic)o(h)h(time...")j
  1618. (Is)d(this)g(a)g(jok)o(e?)0 1978 y(p.)21 b(682)d(HOT)0 2038
  1619. y(p.)j(686-687)e(the)d(v)m(alue)g(of)h(a)f(long)h(exp)q(erience)0
  1620. 2098 y(p.)k(696)15 b(IRIS)e(assa)o(y)o(ed)h(only)g(to)g(9)g(mg)f(lev)o(el)f
  1621. (\\since)i(DOM)g(itself)e(w)o(ould)i(ha)o(v)o(e)g(b)q(een)f(smashingly)g
  1622. (activ)o(e)90 2158 y(at)k(this)f(lev)o(el".)j(Did)d(he)g(not)h(care)f(ab)q
  1623. (out)i(qualitativ)o(e)c(e\013ects)i(at)h(this)f(time?)0 2218
  1624. y(p.)21 b(750-751,)e(459)e(crazy)f(logic)0 2279 y(p.)21 b(752)d(triple)d(b)q
  1625. (ond)i(in)f(pheneth)o(ylamine)0 2339 y(p.)28 b(764)20 b(go)q(o)q(d)g(Tw)o
  1626. (ain)f(quote:)26 b(\\I)18 b(lik)o(e)f(science)g(b)q(ecause)i(it)f(giv)o(es)g
  1627. (one)h(suc)o(h)f(a)h(wholesome)e(return)i(of)90 2399 y(conjecture)c(from)h
  1628. (suc)o(h)g(a)g(tri\015ing)g(in)o(v)o(estmen)o(t)d(of)j(fact.")0
  1629. 2459 y(p.)21 b(768)d(wh)o(y)e(emphasize)e(p)q(otency)0 2519
  1630. y(p.)21 b(774)d(rabbit)e(recta)0 2580 y(p.)21 b(784)d(Do)q(onesbury)f(-)g
  1631. (designer)f(drugs,)g(analog)i(drug)f(act)0 2640 y(p.)k(786)d(austronauts)g
  1632. (of)e(inner)g(space)0 2700 y(p.)21 b(802)d(killing)c(mice)951
  1633. 2825 y(23)p eop
  1634. %%Page: 24 24
  1635. bop 0 50 a Fk(p.)27 b(808-809)20 b(MPM,)d(MIPM,)g(MBM,)g(and)h(MAM)f(w)o(ere)
  1636. h(only)f(assa)o(y)o(ed)i(to)f(lev)o(els)e(that)j(sho)o(w)o(ed)f(them)90
  1637. 110 y(to)k(b)q(e)g(less)g(activ)o(e)f(than)h(MEM.)f(This)h(did)g(not)h(allo)o
  1638. (w)e(c)o(haracterization)g(of)i(their)e(qualitativ)o(e)90 170
  1639. y(prop)q(erties.)g(T)l(o)q(o)d(m)o(uc)o(h)c(in)o(terest)h(here)h(in)f(quan)o
  1640. (titativ)o(e.)0 230 y(p.)29 b(814)20 b(PE)g(is)e(assa)o(y)o(ed)h(to)h(the)e
  1641. (150)i(mg)e(lev)o(el.)27 b(Wh)o(y?)j(when)19 b(other)g(comp)q(ounds)g(w)o
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  1643. 351 y(p.)21 b(822)d(explanation)e(of)g(sp)q(eci\014c)g(meaning)f(of)i(dosage)
  1644. g(ab)q(o)o(v)o(e)f(some)g(v)m(alue)0 411 y(p.)21 b(824)d(sp)q(on)o(taneous)g
  1645. (detonation)f(after)f(standing)h(for)f(a)h(few)f(da)o(ys)g(\(in)g(syn)o
  1646. (thesis\).)0 471 y(p.)21 b(836-837)e(non-psyc)o(hedelic)c(euphorian)o(t)0
  1647. 531 y(p.)21 b(843)d(here)d(there)h(is)g(a)h(forew)o(ard)f(to)h(the)f(syn)o
  1648. (thesis,)f(but)i(not)f(v)o(ery)f(in)o(teresting)0 592 y(p.)21
  1649. b(856-857)e(discussion)e(of)f(S,)g(O)g(c)o(hemistry)0 652 y(p.)21
  1650. b(860-864)e(the)d(essen)o(tial)f(oils)0 712 y(p.)21 b(867-868)e
  1651. (deterioration)d(of)h(Science)d(&)j(Nature)0 772 y(p.)k(869)d(another)f
  1652. (de\014nition)e(of)i Fc(<)0 832 y Fk(p.)29 b(879)19 b(a)g(statemen)o(t)e(of)i
  1653. (an)g(in)o(ten)o(t)f(to)h(base)g(all)f(syn)o(theses)g(on)h(starting)h(from)d
  1654. (commerci)o(ally)e(a)o(v)m(ail-)90 892 y(able)20 b(materials.)33
  1655. b(Then)21 b(he)f(go)q(es)i(on)f(to)g(express)f(paranoia)i(that)f(some)f(of)h
  1656. (these)f(will)f(b)q(ecome)90 953 y(una)o(v)m(ailable)d(due)g(to)g(the)g(W)o
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  1659. (h)o(uman)g(titration)g(w)o(as)g(abandoned)i(due)e(to)h(ph)o(ysical)e
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  1661. (alternate)g(route)g(that)h(do)q(es)g(not)f(w)o(ork)h(w)o(ell.)0
  1662. 1133 y(p.)k(920)d(\\what)f(this)f(b)q(o)q(ok)i(is)e(all)g(ab)q(out")h(qualit)
  1663. o(y)e(not)i(quan)o(tit)o(y)951 2825 y(24)p eop
  1664. %%Page: 25 25
  1665. bop 781 50 a Fm(References)122 207 y Fk(\\F)l(elip)q(e)14 b(is)i(kneeling)e
  1666. (out)i(in)f(the)g(sun,)g(making)g(his)g(no)q(on)o(time)f(dev)o(otionals)h(to)
  1667. h(the)f(living)122 267 y(presence)d(of)g(a)h(certain)f(ro)q(c)o(k)g(bac)o(k)h
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  1670. (tine)e(legend)h(from)f(the)h(last)h(cen)o(tury)l(,)f(Maria)122
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  1673. y(c)o(hild.)32 b(Herders)19 b(found)i(her)f(a)h(w)o(eek)e(later,)h(dead.)34
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  1675. 508 y(n)o(ursing)j(from)f(her)g(corpse.)42 b(Ro)q(c)o(ks)23
  1676. b(near)g(the)f(site)h(of)g(the)g(miracle)d(ha)o(v)o(e)i(since)g(b)q(een)122
  1677. 568 y(the)17 b(ob)s(jects)g(of)g(y)o(early)f(pilgrimages.)22
  1678. b(But)17 b(F)l(elip)q(e's)e(particular)i(ro)q(c)o(k)g(em)o(b)q(o)q(dies)f
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  1683. (time)f(scale.)25 b(Ro)q(c)o(k's)17 b(time)f(scale)h(is)g(a)i(lot)e(more)g
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  1691. (fraction,)f(an)h(out)o(w)o(ard-and-visible)f(fraction.)28
  1692. b(That)19 b(w)o(e)e(m)o(ust)122 1049 y(also)f(lo)q(ok)g(to)h(the)e(un)o
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  1700. y(Pync)o(hon)d(\(1973,)h(p.)22 b(612-613\).)0 1447 y(Bro)o(wn,)d(Rob)q(ert)g
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  1703. b(Edited)15 b(b)o(y)f(Rob)q(ert)i(E.)f(Bro)o(wn)g(&)g(Asso)q(ciates)g(of)h
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  1705. (Dev)o(elopmen)o(t)d(&)k(The)f(Ultimate)d(Authorit)o(y)j(of)g(the)g(Clear)g
  1706. (Ligh)o(t.)0 1661 y(Darth,)24 b(Chewbacca.)40 b(1977.)h(The)22
  1707. b(whole)h(drug)g(man)o(ufacturers)e(catalog.)40 b(Prophet)23
  1708. b(Press,)g(1003)90 1721 y(Manhattan)17 b(Beac)o(h)f(Boulev)m(ard,)f
  1709. (Manhattan)j(Beac)o(h,)c(CA)i(90266.)0 1814 y(Heym,)e(James,)i(and)i(Barry)e
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  1712. b(Sci.,)f(13:)22 b(55{81.)0 1967 y(High)12 b(Times/Lev)o(el)e(Press.)20
  1713. b(1973.)h(Basic)12 b(drug)h(man)o(ufacture.)18 b(High)12 b(Times)e(Press,)j
  1714. (Bo)o(x)f(386,)i(Co)q(op)q(er)90 2027 y(Station,)i(New)g(Y)l(ork,)f(NY)h
  1715. (10003;)i(Lev)o(el)d(Press,)h(Bo)o(x)f(4858,)j(San)e(F)l(rancisco,)g(CA)g
  1716. (94101.)0 2120 y(Huxley)l(,)j(Aldous.)34 b(1954.)h(The)21 b(do)q(ors)h(of)e
  1717. (p)q(erception,)h(and)g(Hea)o(v)o(en)e(and)i(hell.)32 b(Harp)q(er)21
  1718. b(Colophon)90 2180 y(Bo)q(oks,)16 b(Harp)q(er)h(&)f(Ro)o(w,)g(New)g(Y)l(ork.)
  1719. k(Pp.)i(185.)0 2273 y(Lam)o(b,)d(F.)g(Bruce.)29 b(1971.)j(Wizard)19
  1720. b(of)h(the)f(upp)q(er)h(Amazon,)e(the)h(story)h(of)f(Man)o(uel)g(Cordo)o(v)m
  1721. (a-Rios.)90 2333 y(Hough)o(ton)e(Mi\017in)e(Compan)o(y)l(,)g(Boston,)h(205)h
  1722. (p.)0 2426 y(reissued)c(as:)21 b(Lam)o(b,)13 b(F.)g(Bruce)g(and)h(Man)o(uel)f
  1723. (Cordo)o(v)m(a-Rios.)22 b(1987.)g(Wizard)13 b(of)h(the)g(upp)q(er)g(Amazon.)
  1724. 90 2487 y(North)i(A)o(tlan)o(tic,)e(204)k(p.)j(ISBN)15 b(0-938190-8)q(0-6)0
  1725. 2580 y(Lam)o(b,)22 b(F.)g(Bruce.)37 b(1985.)k(Rio)22 b(Tigre)f(and)i(b)q(ey)o
  1726. (ond:)33 b(the)22 b(Amazon)f(jungle)g(medicine)e(of)k(Man)o(uel)90
  1727. 2640 y(Cordo)o(v)m(a.)f(North)13 b(A)o(tlan)o(tic,)f(256)j(p.)21
  1728. b(ISBN)12 b(0-938190-5)q(9-)q(8)17 b(\(describ)q(es)c(the)h(life)e(of)i
  1729. (Cordo)o(v)m(a)h(after)90 2700 y(he)h(escap)q(ed)h(from)e(the)h(Indians\))951
  1730. 2825 y(25)p eop
  1731. %%Page: 26 26
  1732. bop 0 50 a Fk(Leary)l(,)22 b(Timoth)o(y)l(,)e(Ralph)h(Metzner,)f(and)h(Ric)o
  1733. (hard)g(Alp)q(ert.)34 b(1964.)j(The)21 b(psyc)o(hedelic)d(exp)q(erience.)90
  1734. 110 y(Univ)o(ersit)o(y)c(Bo)q(oks,)i(New)g(Hyde)f(P)o(ark.)21
  1735. b(Pp.)h(159.)0 205 y(Masters,)d(R.)f(E.)h(L.,)g(and)g(Jean)g(Houston.)30
  1736. b(1966.)h(The)18 b(v)m(arieties)g(of)h(psyc)o(hedelic)e(exp)q(erience.)27
  1737. b(Dell)90 265 y(Publishing)16 b(Co.,)g(New)g(Y)l(ork.)21 b(Pp.)g(326.)0
  1738. 360 y(Naranjo,)d(Claudio.)23 b(1973.)j(The)17 b(healing)f(journey)l(,)h(new)g
  1739. (approac)o(hes)h(to)f(consciousness.)25 b(Ballan)o(tine)90
  1740. 420 y(Bo)q(oks,)16 b(New)g(Y)l(ork,)g(234)h(p.)0 515 y(Nim)o(ble,)j(Jac)o(k)i
  1741. (B.)f(1986.)42 b(The)22 b(construction)g(and)h(op)q(eration)h(of)e
  1742. (clandestine)g(drug)h(lab)q(oratories.)90 575 y(Lo)q(ompanics)17
  1743. b(Unlimite)o(d,)d(P)l(.O.)h(Bo)o(x)h(1197,)i(P)o(ort)e(T)l(o)o(wnsend,)h(W)-5
  1744. b(A)16 b(98368.)23 b(ISBN)16 b(0-915197-40)q(-)90 635 y(7.)0
  1745. 730 y(Pync)o(hon,)g(Thomas.)21 b(1973.)i(Gra)o(vit)o(y's)15
  1746. b(Rain)o(b)q(o)o(w.)21 b(The)16 b(Viking)g(Press,)g(N.Y.)e(Pp.)22
  1747. b(760.)0 824 y(Sc)o(h)o(ultes,)10 b(Ric)o(hard)h(Ev)m(ans,)i(and)e(Alb)q(ert)
  1748. g(Hofmann.)18 b(1980.)k(The)11 b(b)q(otan)o(y)h(and)f(c)o(hemistry)e(of)i
  1749. (hallucino-)90 885 y(gens.)21 b(Revised)12 b(and)j(enlarged)e(second)h
  1750. (edition.)20 b(Charles)13 b(C.)h(Thomas)f(Publishers,)h(Bannerstone)90
  1751. 945 y(House,)i(301-327)j(East)e(La)o(wrence)f(Av)o(e.,)e(Spring\014eld,)h
  1752. (Illinois.)20 b(ISBN)15 b(0-398-0386)q(3-5)q(.)0 1039 y(Sh)o(ulgin,)e
  1753. (Alexander)g(T.)h(1978.)21 b(Psyc)o(hotomimetic)10 b(drugs:)21
  1754. b(structure-activit)o(y)12 b(relationships.)20 b(In:)g(L.)90
  1755. 1100 y(L.)e(Iv)o(ersen,)g(S.)g(D.)g(Iv)o(ersen,)f(and)i(S.)f(H.)g(Sn)o(yder)g
  1756. ([eds.])27 b(\\Handb)q(o)q(ok)20 b(of)f(Psyc)o(hopharmacology)l(,)90
  1757. 1160 y(V)l(ol.)i(11".)h(Plen)o(um)14 b(Press,)i(New)g(Y)l(ork.)21
  1758. b(Pp.)g(243-333.)j(\(an)17 b(excellen)o(t)c(review\))0 1255
  1759. y(Sh)o(ulgin,)i(A.)g(T.)h(1981.)23 b(Hallucinogens.)d(In:)h(Manfred)16
  1760. b(E.)g(W)l(ol\013)h([ed.],)d(\\Burger's)i(Medicinal)e(Chem-)90
  1761. 1315 y(istry)l(,)i(4th)i(ed.,)e(P)o(art)h(I)q(I)q(I.")f(John)i(Wiley)d(&)i
  1762. (Sons,)h(Inc.)23 b(Pp.)g(1109-1137)q(.)j(\(an)17 b(excellen)o(t)e(review,)90
  1763. 1375 y(co)o(v)o(ers)g(the)h(indoles,)g(as)h(w)o(ell)d(as)j(other)g(groups\))0
  1764. 1470 y(Sh)o(ulgin,)e(A.)g(T.)g(1983.)23 b(Tw)o(en)o(t)o(y)15
  1765. b(y)o(ears)g(on)h(an)h(ev)o(er-c)o(hanging)e(quest.)20 b(In:)h(Lester)16
  1766. b(Grinsp)q(o)q(on,)h(James)90 1530 y(B.)12 b(Bak)m(alar)i([eds.],)e(\\Psyc)o
  1767. (hedelic)g(Re\015ections",)h(Human)f(Sciences)g(Press,)i(Inc.,)e(New)h(Y)l
  1768. (ork.)20 b(Pp.)90 1590 y(205-212.)k(\(an)17 b(excellen)o(t)c(review\))0
  1769. 1685 y(Sh)o(ulgin,)j(A.)g(T.,)g(L.)h(A.)f(Sh)o(ulgin.)22 b(1991.)j(PIHKAL,)15
  1770. b(pheneth)o(ylamines)g(I)h(ha)o(v)o(e)g(kno)o(wn)h(and)g(lo)o(v)o(ed,)f(a)90
  1771. 1745 y(c)o(hemical)d(lo)o(v)o(e)i(story)l(.)22 b(T)l(ransform)16
  1772. b(Press,)g(Lafa)o(y)o(ette,)f(CA.)h(Pp.)21 b(978.)0 1840 y(Sh)o(ulgin,)f(A.)f
  1773. (T.,)i(L.)f(A.)f(Sh)o(ulgin,)i(and)f(P)l(.)g(Jacob.)34 b(1986.)g(A)20
  1774. b(proto)q(col)h(for)f(the)g(ev)m(aluation)h(of)f(new)90 1900
  1775. y(psyc)o(hoactiv)o(e)14 b(drugs.)21 b(Metho)q(ds)16 b(and)g(Findings)f(in)g
  1776. (Exp)q(erimen)o(tal)e(and)i(Clinical)f(Pharmacology)90 1960
  1777. y(8\(5\):)22 b(313{320.)i(\(a)16 b(real)g(ey)o(e)f(op)q(ener\))0
  1778. 2055 y(Sh)o(ulgin,)g(A.)h(T.,)f(S.)h(Bunnell,)f(and)i(T.)f(Sargen)o(t.)21
  1779. b(1961.)i(The)16 b(psyc)o(hotomimetic)d(prop)q(erties)j(of)g(3,4,5-)90
  1780. 2115 y(trimetho)o(xy)o(am)o(phetam)o(i)o(ne.)i(Nature)e(189:)23
  1781. b(10011{1012)q(.)0 2210 y(Smith,)15 b(Mic)o(hael)h(V)l(alen)o(tine.)22
  1782. b(1973.)k(Psyc)o(hedelic)15 b(c)o(hemistry)l(.)21 b(Rip)c(O\013)h(Press)f
  1783. (\(\\Serving)g(the)g(Rev)o(o-)90 2270 y(lution)f(since)f(1969"\),)j(P)l(.O.)e
  1784. (Bo)o(x)f(14158,)j(San)f(F)l(rancisco,)e(CA)h(94114.)0 2365
  1785. y(Smith,)h(Mic)o(hael)g(V)l(alen)o(tine.)27 b(1981.)k(Psyc)o(hedelic)16
  1786. b(c)o(hemistry)l(.)26 b(Lo)q(ompanics)19 b(Unlimited,)d(P)l(.O.)i(Bo)o(x)90
  1787. 2425 y(1197,)25 b(P)o(ort)d(T)l(o)o(wnsend,)i(W)-5 b(A)22 b(98368.)41
  1788. b(ISBN)21 b(0-915179-10)q(-5.)42 b(M.)22 b(V.)f(Smith)g(w)o(as)h(the)g(main)
  1789. 90 2485 y(c)o(haracter)f(of)h(\\Stranger)g(in)g(a)g(strange)g(land")g(b)o(y)f
  1790. (Rob)q(ert)h(A.)f(Heinlein,)f(a)i(no)o(v)o(el)e(w)o(ell)h(w)o(orth)90
  1791. 2545 y(reading.)0 2640 y(Sn)o(yder,)h(Solomon)g(H.,)g(H.)f(W)l(eingartner,)i
  1792. (and)f(L.)g(A.)f(F)l(aillace.)37 b(1970.)j(DOET)23 b(\(2,5-dimetho)o(xy-)90
  1793. 2700 y(4-eth)o(ylamphetamine\))e(and)k(DOM)f(\(STP\))g(\(2,5-)h(dimetho)o
  1794. (xy-4-meth)o(y)o(lam)o(phetam)o(i)o(ne\),)e(new)951 2825 y(26)p
  1795. eop
  1796. %%Page: 27 27
  1797. bop 90 50 a Fk(psyc)o(hotropic)22 b(agen)o(ts:)35 b(their)22
  1798. b(e\013ects)h(in)g(man.)40 b(In:)34 b(D.)23 b(H.)f(Efron)h([ed.],)g(\\Psyc)o
  1799. (hotomimeti)o(c)90 110 y(Drugs",)17 b(Ra)o(v)o(en)e(Press,)i(N.)e(Y.)g(Pp.)22
  1800. b(247-264.)0 201 y(Sn)o(yder,)11 b(S.)f(H.,)h(H.)f(W)l(eingartner,)h(and)h
  1801. (L.)e(A.)g(F)l(aillace.)18 b(1971.)j(DOET)12 b(\(2,5-dimetho)o(xy-4-eth)o
  1802. (ylam)o(phetam)o(ine\),)90 262 y(a)17 b(new)f(psyc)o(hotropic)g(drug.)21
  1803. b(Arc)o(hiv)o(es)15 b(of)h(General)g(Psyc)o(hiatry)f(24:)22
  1804. b(50-55.)0 353 y(Sn)o(yder,)d(S.)g(H.,)g(S.)g(Unger,)h(R.)e(Blatc)o(hley)l(,)
  1805. g(and)i(C.)f(F.)g(Barfknec)o(h)o(t.)29 b(1974.)j(Stereosp)q(eci\014c)19
  1806. b(actions)90 413 y(of)k(DOET)g(\(2,5-dimetho)o(xy-4-eth)o(ylamphetam)o(i)o
  1807. (ne\))c(in)k(man.)39 b(Arc)o(h.)g(Gen.)h(Psyc)o(hiatry)22 b(31:)90
  1808. 473 y(103-106.)0 565 y(Titeler,)e(M.,)g(R.)g(A.)g(Ly)o(on,)i(and)f(R.)f(A.)g
  1809. (Glennon.)34 b(1988.)i(Radioligand)21 b(binding)g(evidence)d(impli-)90
  1810. 625 y(cates)i(the)h(brain)f(5-HT)548 632 y Fg(2)589 625 y Fk(receptor)g(as)h
  1811. (a)g(site)f(of)g(action)h(for)g(LSD)g(and)g(phen)o(ylisoprop)o(ylamine)90
  1812. 685 y(hallucinogens.)g(Psyc)o(hopharmacology)l(,)15 b(94:)22
  1813. b(213{216.)0 776 y(W)l(atts,)17 b(Alan)f(W.)g(1962.)24 b(The)17
  1814. b(jo)o(y)o(ous)f(cosmology)l(,)g(adv)o(en)o(tures)g(in)g(the)g(c)o(hemistry)e
  1815. (of)j(consciousness.)90 836 y(Vin)o(tage)f(Bo)q(oks,)g(a)h(division)e(of)i
  1816. (Random)e(House,)h(New)g(Y)l(ork.)21 b(Pp.)g(100.)0 928 y(W)l(eingartner,)e
  1817. (H.,)f(S.)h(H.)f(Sn)o(yder,)h(L.)g(A.)f(F)l(aillace,)g(and)i(H.)e(Markley)l
  1818. (.)28 b(1970.)j(Altered)18 b(free)g(asso)q(ci-)90 988 y(ations:)25
  1819. b(some)16 b(cognitiv)o(e)h(e\013ects)g(of)h(DOET)g(\(2,5-)h(dimetho)o
  1820. (xy-4-eth)o(ylam)o(phetam)o(i)o(ne\).)k(Beha)o(v-)90 1048 y(ioral)16
  1821. b(Science)f(15\(4\):)22 b(297-303.)951 2825 y(27)p eop
  1822. %%Page: 28 28
  1823. bop 388 50 a Fm(A)28 b(T)-7 b(able)28 b(of)g(311)g(Pheneth)n(ylamines)73
  1824. 236 y Fk(Sh)o(ulgin)16 b(crossed)g(the)g(diamond)g(with)g(the)g(p)q(earl)g
  1825. (and)h(ga)o(v)o(e)f(birth)g(to)h(all)e(forms)h(of)g(ligh)o(t:)122
  1826. 422 y(\\It)c(is)h(early)f(morning)f(no)o(w.)21 b(Slothrop's)13
  1827. b(breath)g(is)f(white)g(on)h(the)f(air.)20 b(He)12 b(is)h(just)f(up)h(from)
  1828. 122 482 y(a)k(dream.)22 b(P)o(art)17 b(I)f(of)h(a)g(p)q(o)q(em,)f(with)h(w)o
  1829. (o)q(o)q(dcuts)h(accompan)o(ying)d(the)i(text)f(-)h(a)g(w)o(oman)f(is)122
  1830. 542 y(attending)e(a)h(dog)g(sho)o(w)g(whic)o(h)f(is)g(also,)h(in)f(some)f(w)o
  1831. (a)o(y)l(,)h(a)g(stud)h(service.)k(She)14 b(has)h(brough)o(t)122
  1832. 602 y(her)22 b(P)o(ekingese,)f(a)i(female)d(with)h(a)i(sic)o(k)o(eningly)c
  1833. (cute)j(name,)g(Mimsy)d(or)k(Go)q(o-Go)q(o)i(or)122 662 y(something,)14
  1834. b(here)h(to)h(b)q(e)f(serviced.)20 b(She)15 b(is)g(passing)i(the)e(time)e(in)
  1835. i(a)h(garden)g(setting,)f(with)122 723 y(some)f(other)h(middle-class)e
  1836. (ladies)h(lik)o(e)f(herself,)h(when)h(from)f(some)g(enclosure)g(nearb)o(y)h
  1837. (she)122 783 y(hears)g(the)f(sound)i(of)f(her)f(bitc)o(h,)f(coming.)20
  1838. b(The)14 b(sound)i(go)q(es)f(on)h(and)f(on)g(for)g(m)o(uc)o(h)d(longer)122
  1839. 843 y(than)23 b(seems)d(appropriate,)k(and)f(she)f(suddenly)g(realizes)f
  1840. (that)i(the)f(sound)h(is)f(her)g(o)o(wn)122 903 y(v)o(oice,)14
  1841. b(this)i(in)o(terminable)d(cry)j(of)g(dog-pleasure.)22 b(The)16
  1842. b(others,)g(p)q(olitely)l(,)e(are)i(pretending)122 963 y(not)j(to)f(notice.)
  1843. 26 b(She)19 b(feels)e(shame,)g(but)h(is)g(helpless,)g(driv)o(en)f(no)o(w)h(b)
  1844. o(y)g(a)g(need)g(to)h(go)g(out)122 1023 y(and)k(\014nd)f(other)h(animal)e(sp)
  1845. q(ecies)h(to)g(fuc)o(k.)39 b(She)22 b(suc)o(ks)g(the)g(p)q(enis)h(of)f(a)h(m)
  1846. o(ulticolored)122 1084 y(mongrel)c(who)i(has)g(tried)f(to)h(moun)o(t)e(her)h
  1847. (in)g(the)g(street.)33 b(Out)21 b(in)f(a)h(barren)f(\014eld)g(near)122
  1848. 1144 y(a)g(barb)q(ed-wire)g(fence,)f(win)o(ter)g(\014res)h(across)g(the)g
  1849. (clouds,)g(a)g(tall)f(horse)h(comp)q(els)e(her)i(to)122 1204
  1850. y(kneel,)d(passiv)o(ely)l(,)f(and)j(kiss)e(his)h(ho)q(o)o(v)o(es.)27
  1851. b(Cats)18 b(and)h(minks,)d(h)o(y)o(enas)h(and)i(rabbits,)f(fuc)o(k)122
  1852. 1264 y(her)d(inside)g(automobiles,)g(lost)g(at)h(nigh)o(t)g(in)f(the)h
  1853. (forests,)f(out)h(b)q(eside)g(a)g(w)o(aterhole)f(in)g(the)122
  1854. 1324 y(desert.)122 1420 y(\\As)21 b(P)o(art)f(I)q(I)g(b)q(egins,)h(she)g(has)
  1855. g(disco)o(v)o(ered)e(she's)h(pregnan)o(t.)34 b(Her)19 b(h)o(usband,)j(a)f
  1856. (dum)o(b,)122 1480 y(easygoing)16 b(screen)f(do)q(or)i(salesman,)d(mak)o(es)g
  1857. (an)i(agreemen)o(t)e(with)h(her:)20 b(her)c(o)o(wn)f(promise)122
  1858. 1540 y(is)h(nev)o(er)e(stated,)i(but)g(in)f(return,)h(nine)f(mon)o(ths)g
  1859. (from)g(no)o(w,)g(he)h(will)f(tak)o(e)g(her)h(where)f(she)122
  1860. 1600 y(w)o(an)o(ts)20 b(to)h(go.)33 b(So)21 b(it)e(is)h(that)h(close)e(to)i
  1861. (the)f(end)g(of)g(her)g(term)e(he)i(is)g(out)h(on)f(the)g(riv)o(er,)122
  1862. 1661 y(and)14 b(American)e(riv)o(er,)g(in)i(a)g(ro)o(wb)q(oat,)h(hauling)f
  1863. (on)h(the)e(oars,)i(carrying)f(her)f(on)h(a)h(journey)l(.)122
  1864. 1721 y(The)h(k)o(ey)f(color)h(in)g(this)h(section)e(is)h(violet.)122
  1865. 1816 y(\\P)o(art)i(I)q(I)q(I)g(\014nds)h(her)e(at)i(the)e(b)q(ottom)h(of)h
  1866. (the)e(riv)o(er.)25 b(She)18 b(has)h(dro)o(wned.)27 b(But)17
  1867. b(all)h(forms)122 1876 y(of)h(life)e(\014ll)h(her)g(w)o(om)o(b.)27
  1868. b(`Using)19 b(her)f(as)h(mermaid')c(\(line)j(7\),)h(they)f(transp)q(ort)i
  1869. (her)f(do)o(wn)122 1937 y(through)c(these)e(green)h(riv)o(er-depths.)20
  1870. b(`It)13 b(w)o(as)h(do)o(wn,)h(and)f(out)g(again./)h(Old)f(Squalidozzi,)122
  1871. 1997 y(ploughman)h(of)g(the)g(deep,/)g(A)o(t)f(the)h(end)h(of)f(his)g(da)o
  1872. (y's)g(so)o(wing/)h(Sees)f(her)g(v)o(erdigris)f(b)q(elly)122
  1873. 2057 y(among)23 b(the)f(w)o(eeds')g(\(lines)g(10-13\),)j(and)f(brings)f(her)f
  1874. (bac)o(k)h(up.)41 b(He)22 b(is)g(a)h(classically-)122 2117
  1875. y(b)q(earded)18 b(Neptune)f(\014gure)h(with)g(an)g(old)g(serene)f(face.)26
  1876. b(F)l(rom)16 b(out)i(of)h(her)e(b)q(o)q(dy)i(streams)122 2177
  1877. y(a)e(\015o)q(o)q(d)h(no)o(w)g(of)f(di\013eren)o(t)e(creatures,)i(o)q
  1878. (ctopuses,)g(reindeer,)e(k)m(angaro)q(os,)k(`Who)e(can)g(sa)o(y)122
  1879. 2238 y(all)e(the)h(life/)f(That)i(left)e(her)h(w)o(om)o(b)e(that)i(da)o(y?')
  1880. 22 b(Squalidozzi)14 b(can)i(only)g(catc)o(h)g(a)g(glimpse)122
  1881. 2298 y(of)g(the)f(amazing)g(spill)g(as)h(he)g(b)q(ears)g(her)g(bac)o(k)f(to)o
  1882. (w)o(ard)h(the)g(surface.)21 b(Ab)q(o)o(v)o(e,)14 b(it)i(is)f(a)h(mild)122
  1883. 2358 y(and)j(sunlit)g(green)f(lak)o(e)g(or)h(p)q(ond,)h(grassy)g(at)f(the)f
  1884. (banks,)i(shaded)f(b)o(y)f(willo)o(ws.)29 b(Insects)122 2418
  1885. y(whine)14 b(and)h(ho)o(v)o(er.)20 b(The)15 b(k)o(ey)e(color)i(no)o(w)g(is)f
  1886. (green.)20 b(`And)14 b(there)g(as)h(it)f(brok)o(e)h(to)f(sun/)i(Her)122
  1887. 2478 y(corpse)f(found)g(sleep)g(in)f(the)h(w)o(ater/)g(And)g(in)f(the)h
  1888. (summer)d(depths/)k(The)f(creatures)f(to)q(ok)122 2539 y(their)j(w)o(a)o(y/)g
  1889. (Eac)o(h)h(to)f(its)h(prop)q(er)g(lo)o(v)o(e/)e(In)h(the)g(heigh)o(t)g(of)h
  1890. (afterno)q(on/)h(As)e(the)h(p)q(eaceful)122 2599 y(riv)o(er)d(w)o(en)o
  1891. (t...."')k(Pync)o(hon)d(\(1973,)h(p.)22 b(446-447\))951 2825
  1892. y(28)p eop
  1893. %%Page: 29 29
  1894. bop 103 110 a Fa(STATUS:)154 230 y(A)51 b(active)154 291 y(T)g(only)24
  1895. b(threshold)e(levels)i(were)g(tasted)154 351 y(S)51 b(only)24
  1896. b(sub-thresh)o(ol)o(d)f(levels)g(tasted)154 411 y(U)51 b(untasted)154
  1897. 471 y(N)g(not)24 b(active)154 531 y(X)51 b(signs)23 b(of)i(toxicity)e(below)h
  1898. (active)f(level)154 592 y(P)51 b(physical)22 b(more)j(than)f(mental)154
  1899. 652 y(O)51 b(other,)23 b(non-psyche)o(del)o(ic)f(activity)154
  1900. 712 y(F)51 b(synthesis)22 b(not)j(finished)0 832 y(Abbreviati)o(ons)o(:)154
  1901. 953 y(A)76 b(=)26 b(amphetami)o(ne)154 1013 y(PEA)e(=)i(phenethyl)o(ami)o(ne)
  1902. 154 1073 y(B)76 b(=)26 b(butane)154 1133 y(MDP)e(=)i(methylene)o(dio)o(xy)o
  1903. (phe)o(nyl)0 1254 y(Note)e(that)g(dosages)f(listed)h(for)g(T,)h(S)h(and)e(N)h
  1904. (categories)d(indicate)h(what)h(levels)0 1314 y(these)g(compounds)e(have)i
  1905. (been)g(tested)g(to.)51 1494 y(#)51 b(Code)127 b(Status)23
  1906. b(Dosage)49 b(Compact)23 b(chemical)g(name)0 1555 y(----------)o(---)o(--)o
  1907. (---)o(---)o(---)o(--)o(---)o(---)o(---)o(--)o(---)o(---)o(--)o(---)o(---)o
  1908. (---)o(--)o(---)o(---)o(---)o(--)o(---)o(---)o(--)o(---)o(-)51
  1909. 1615 y(1)j(AEM)280 b(S)77 b(220)f(alpha-Eth)o(yl-)o(3,4)o(,5)o(-tr)o(ime)o
  1910. (tho)o(xy)o(-PE)o(A)51 1675 y(1)26 b(APM)280 b(U)231 b(alpha-Pro)o(pyl)o(-3,)
  1911. o(4,)o(5-t)o(rim)o(eth)o(ox)o(y-P)o(EA)51 1735 y(1)26 b(ABM)280
  1912. b(U)231 b(alpha-But)o(yl-)o(3,4)o(,5)o(-tr)o(ime)o(tho)o(xy)o(-PE)o(A)51
  1913. 1795 y(1)26 b(AAM)280 b(U)231 b(alpha-Amy)o(l-3)o(,4,)o(5-)o(tri)o(met)o(hox)
  1914. o(y-)o(PEA)51 1856 y(2)26 b(AL)306 b(A)51 b(20-35)f(4-Allylox)o(y-3)o(,5-)o
  1915. (di)o(met)o(hox)o(y-P)o(EA)51 1916 y(3)26 b(ALEPH)228 b(A)51
  1916. b(5-10)76 b(4-Methylt)o(hio)o(-2,)o(5-)o(dim)o(eth)o(oxy)o(-A)51
  1917. 1976 y(4)26 b(ALEPH-2)176 b(A)77 b(4-8)f(4-Ethylth)o(io-)o(2,5)o(-d)o(ime)o
  1918. (tho)o(xy-)o(A)51 2036 y(5)26 b(ALEPH-4)176 b(A)51 b(7-12)76
  1919. b(4-Isoprop)o(ylt)o(hio)o(-2)o(,5-)o(dim)o(eth)o(ox)o(y-A)51
  1920. 2096 y(6)26 b(ALEPH-6)176 b(A)77 b(>40)f(4-Phenylt)o(hio)o(-2,)o(5-)o(dim)o
  1921. (eth)o(oxy)o(-A)51 2156 y(7)26 b(ALEPH-7)176 b(A)77 b(4-7)f(4-Propylt)o(hio)o
  1922. (-2,)o(5-)o(dim)o(eth)o(oxy)o(-A)51 2217 y(8)26 b(ARIADNE)176
  1923. b(O)51 b(12-32)f(2,5-Dimet)o(hox)o(y-a)o(lp)o(ha-)o(eth)o(yl-)o(4-)o(met)o
  1924. (hyl)o(-PE)o(A)51 2277 y(8)26 b(?)332 b(U)231 b(1-\(2,5-di)o(met)o(hox)o(yp)o
  1925. (hen)o(yl\))o(-2-)o(am)o(ino)o(but)o(ane)51 2337 y(8)26 b(?)332
  1926. b(U)231 b(1-\(3,4-di)o(met)o(hox)o(yp)o(hen)o(yl\))o(-2-)o(am)o(ino)o(but)o
  1927. (ane)51 2397 y(8)26 b(?)332 b(U)231 b(1-\(2,5-di)o(met)o(hox)o(y-)o(4-b)o
  1928. (rom)o(oph)o(en)o(yl\))o(-2-)o(ami)o(no)o(but)o(ane)51 2457
  1929. y(8)26 b(?)332 b(U)231 b(N,N-dimet)o(hyl)o(-1-)o(\(2)o(,4-)o(dim)o(eth)o(ox)o
  1930. (yph)o(eny)o(l\)-)o(2-)o(ami)o(nob)o(ut)o(ane)51 2518 y(8)26
  1931. b(?)332 b(U)231 b(N,N-dimet)o(hyl)o(-1-)o(\(2)o(,5-)o(dim)o(eth)o(ox)o(yph)o
  1932. (eny)o(l\)-)o(2-)o(ami)o(nob)o(ut)o(ane)51 2578 y(8)26 b(?)332
  1933. b(U)231 b(N,N-dimet)o(hyl)o(-1-)o(\(3)o(,5-)o(dim)o(eth)o(ox)o(yph)o(eny)o
  1934. (l\)-)o(2-)o(ami)o(nob)o(ut)o(ane)51 2638 y(8)26 b(?)332 b(U)231
  1935. b(1-\(2,5-di)o(met)o(hox)o(y-)o(4-m)o(eth)o(ylp)o(he)o(nyl)o(\)-N)o(-hy)o(dr)
  1936. o(oxy)o(-2-)o(am)o(ino)o(B)51 2698 y(8)26 b(?)332 b(U)231 b(1-\(2,4,6-)o(tri)
  1937. o(met)o(ho)o(xyp)o(hen)o(yl\))o(-2)o(-am)o(ino)o(but)o(an)o(e)951
  1938. 2825 y Fk(29)p eop
  1939. %%Page: 30 30
  1940. bop 51 50 a Fa(8)26 b(?)332 b(U)231 b(3,6-dimet)o(hox)o(y-2)o(,4)o(-di)o(met)
  1941. o(hyl)o(-A)51 110 y(9)26 b(ASB)280 b(A)26 b(200-280)d(3,4-Dieth)o(oxy)o(-5-)o
  1942. (me)o(tho)o(xy-)o(PEA)26 170 y(10)i(B)332 b(P)51 b(>150)76
  1943. b(4-Butoxy-)o(3,5)o(-di)o(me)o(tho)o(xy-)o(PEA)26 230 y(11)25
  1944. b(BEATRICE)150 b(P)77 b(>30)f(2,5-Dimet)o(hox)o(y-4)o(,N)o(-di)o(met)o(hyl)o
  1945. (-A)26 291 y(11)25 b(?)332 b(U)231 b(N-Cyclopr)o(opy)o(l-2)o(,5)o(-di)o(met)o
  1946. (hox)o(y-)o(4-m)o(eth)o(yl-)o(A)26 351 y(12)25 b(BIS-TOM)176
  1947. b(X)77 b(160)f(2,5-Bisme)o(thy)o(lth)o(io)o(-4-)o(met)o(hyl)o(-A)26
  1948. 411 y(13)25 b(2C-BIS-TO)o(M)99 b(U)231 b(2,5-Bis-\()o(met)o(hyl)o(th)o(io\))o
  1949. (-4-)o(met)o(hy)o(lph)o(ene)o(thy)o(la)o(min)o(e)26 471 y(13)25
  1950. b(BOB)280 b(P)51 b(10-20)f(4-Bromo-2)o(,5,)o(bet)o(a-)o(tri)o(met)o(hox)o(y-)
  1951. o(PEA)26 531 y(14)25 b(BOD)280 b(A)51 b(15-25)f(2,5,beta-)o(Tri)o(met)o(ho)o
  1952. (xy-)o(4-m)o(eth)o(yl)o(-PE)o(A)26 592 y(14)25 b(BOED)254 b(A)51
  1953. b(70-75)f(2,5-Dimet)o(hox)o(y-b)o(et)o(a-e)o(tho)o(xy-)o(4-)o(met)o(hyl)o
  1954. (-PE)o(A)26 652 y(15)25 b(BOH)280 b(P)26 b(80-120)49 b(beta-Meth)o(oxy)o(-3,)
  1955. o(4-)o(met)o(hyl)o(ene)o(di)o(oxy)o(-PE)o(A)26 712 y(16)25
  1956. b(BOHD)254 b(X)77 b(50)102 b(2,5-Dimet)o(hox)o(y-b)o(et)o(a-h)o(ydr)o(oxy)o
  1957. (-4)o(-me)o(thy)o(l-P)o(EA)26 772 y(17)25 b(BOM)280 b(S)77
  1958. b(200)f(3,4,5,bet)o(a-T)o(etr)o(am)o(eth)o(oxy)o(-PE)o(A)26
  1959. 832 y(18)25 b(4-Br-3,5-)o(DM)o(A)48 b(O)j(4-10)76 b(4-Bromo-3)o(,5-)o(dim)o
  1960. (et)o(hox)o(y-A)26 892 y(19)25 b(2-Br-4,5-)o(MD)o(A)48 b(S)77
  1961. b(350)f(2-Bromo-4)o(,5-)o(met)o(hy)o(len)o(edi)o(oxy)o(-A)26
  1962. 953 y(20)25 b(2C-B)254 b(A)51 b(12-24)f(4-Bromo-2)o(,5-)o(dim)o(et)o(hox)o
  1963. (y-P)o(EA)26 1013 y(20)25 b(2CB-2ETO)150 b(A)51 b(15-50)f(4-Bromo-2)o(-et)o
  1964. (hox)o(y-)o(5-m)o(eth)o(oxy)o(-P)o(EA)26 1073 y(20)25 b(2CB-2,5-D)o(IE)o(TO)d
  1965. (S)77 b(50)102 b(4-Bromo-2)o(,5-)o(die)o(th)o(oxy)o(-PE)o(A)26
  1966. 1133 y(20)25 b(6-BR-DMPE)o(A)99 b(A)51 b(60iv)76 b(2-Bromo-4)o(,5-)o(dim)o
  1967. (et)o(hox)o(y-P)o(EA)26 1193 y(20)25 b(?)332 b(A)51 b(>60iv)f(N-Methyl-)o
  1968. (2-b)o(rom)o(o-)o(4,5)o(-di)o(met)o(ho)o(xy-)o(PEA)26 1254
  1969. y(21)25 b(3C-BZ)228 b(A)26 b(25-200)49 b(4-Benzylo)o(xy-)o(3,5)o(-d)o(ime)o
  1970. (tho)o(xy-)o(A)26 1314 y(21)25 b(3C-FBZ)202 b(S)103 b(4)f(3,5-Dimet)o(hox)o
  1971. (y-4)o(-\()o(4-f)o(luo)o(rob)o(en)o(zyl)o(oxy)o(\)am)o(ph)o(eta)o(min)o(e)26
  1972. 1374 y(22)25 b(2C-C)254 b(A)51 b(20-40)f(4-Chloro-)o(2,5)o(-di)o(me)o(tho)o
  1973. (xy-)o(PEA)26 1434 y(22)25 b(2C-CN)228 b(U)j(2,5-Dimet)o(hox)o(y-4)o(-c)o
  1974. (yan)o(o-P)o(EA)26 1494 y(22)25 b(2C-COOH)176 b(U)231 b(2,5-Dimet)o(hox)o
  1975. (y-4)o(-c)o(arb)o(oxy)o(-PE)o(A)26 1555 y(23)25 b(2C-D)254
  1976. b(A)51 b(20-60)f(4-Methyl-)o(2,5)o(-di)o(me)o(tho)o(xy-)o(PEA)26
  1977. 1615 y(23)25 b(?)332 b(U)231 b(4,N-dimet)o(hyl)o(-2,)o(5-)o(dim)o(eth)o(oxy)o
  1978. (-P)o(EA)26 1675 y(23)25 b(?)332 b(U)231 b(4,N,N-tri)o(met)o(hyl)o(-2)o(,5-)o
  1979. (dim)o(eth)o(ox)o(y-P)o(EA)26 1735 y(23)25 b(2CD-2ETO)150 b(A)77
  1980. b(60)102 b(2-Ethoxy-)o(5-m)o(eth)o(ox)o(y-4)o(-me)o(thy)o(l-)o(PEA)26
  1981. 1795 y(23)25 b(2CD-5ETO)150 b(A)51 b(40-50)f(5-Ethoxy-)o(2-m)o(eth)o(ox)o
  1982. (y-4)o(-me)o(thy)o(l-)o(PEA)26 1856 y(23)25 b(2CD-2,5-D)o(IE)o(TO)d(T)77
  1983. b(55)102 b(2,5-Dieth)o(oxy)o(-4-)o(me)o(thy)o(l-P)o(EA)26 1916
  1984. y(24)25 b(2C-E)254 b(A)51 b(10-25)f(4-Ethyl-2)o(,5-)o(dim)o(et)o(hox)o(y-P)o
  1985. (EA)26 1976 y(24)25 b(2CE-5ETO)150 b(A)51 b(10-15)f(5-Ethoxy-)o(4-e)o(thy)o
  1986. (l-)o(2-m)o(eth)o(oxy)o(-P)o(EA)26 2036 y(25)25 b(3C-E)254
  1987. b(A)51 b(30-60)f(4-Ethoxy-)o(3,5)o(-di)o(me)o(tho)o(xy-)o(A)26
  1988. 2096 y(26)25 b(2C-F)254 b(S)77 b(250)f(4-Fluoro-)o(2,5)o(-di)o(me)o(tho)o
  1989. (xy-)o(PEA)26 2156 y(26)25 b(DOF)280 b(U)231 b(4-Fluoro-)o(2,5)o(-di)o(me)o
  1990. (tho)o(xy-)o(A)26 2217 y(27)25 b(2C-G)254 b(A)51 b(20-35)f(3,4-Dimet)o(hyl)o
  1991. (-2,)o(5-)o(dim)o(eth)o(oxy)o(-P)o(EA)26 2277 y(28)25 b(2C-G-3)202
  1992. b(A)51 b(12-24)f(3,4-Trime)o(thy)o(len)o(e-)o(2,5)o(-di)o(met)o(ho)o(xy-)o
  1993. (PEA)26 2337 y(29)25 b(2C-G-4)202 b(I)231 b(3,4-Tetra)o(met)o(hyl)o(en)o(e-2)
  1994. o(,5-)o(dim)o(et)o(hox)o(y-P)o(EA)26 2397 y(30)25 b(2C-G-5)202
  1995. b(A)51 b(10-16)f(3,4-Norbo)o(rny)o(l-2)o(,5)o(-di)o(met)o(hox)o(y-)o(PEA)26
  1996. 2457 y(31)25 b(2C-G-N)202 b(A)51 b(20-40)f(1,4-Dimet)o(hox)o(yna)o(ph)o(thy)o
  1997. (l-2)o(-et)o(hy)o(lam)o(ine)26 2518 y(32)25 b(2C-H)254 b(U)231
  1998. b(2,5-Dimet)o(hox)o(y-P)o(EA)26 2578 y(33)25 b(2C-I)254 b(A)51
  1999. b(14-22)f(4-Iodo-2,)o(5-d)o(ime)o(th)o(oxy)o(-PE)o(A)26 2638
  2000. y(33)25 b(2CI-2ETO)150 b(A)51 b(5-50)76 b(2-Ethoxy-)o(4-i)o(odo)o(-5)o(-me)o
  2001. (tho)o(xy-)o(PE)o(A)26 2698 y(34)25 b(2C-N)254 b(A)26 b(100-150)d(4-Nitro-2)o
  2002. (,5-)o(dim)o(et)o(hox)o(y-P)o(EA)951 2825 y Fk(30)p eop
  2003. %%Page: 31 31
  2004. bop 26 50 a Fa(35)25 b(2C-O-4)202 b(T)77 b(60)102 b(4-Isoprop)o(oxy)o(-2,)o
  2005. (5-)o(dim)o(eth)o(oxy)o(-P)o(EA)26 110 y(36)25 b(2C-P)254 b(A)51
  2006. b(6-10)76 b(4-Propyl-)o(2,5)o(-di)o(me)o(tho)o(xy-)o(PEA)26
  2007. 170 y(37)25 b(CPM)280 b(A)51 b(60-80)f(4-Cyclopr)o(opy)o(lme)o(th)o(oxy)o
  2008. (-3,)o(5-d)o(im)o(eth)o(oxy)o(-PE)o(A)26 230 y(38)25 b(2C-SE)228
  2009. b(T)51 b(50-70)f(4-Methyls)o(ele)o(no-)o(2,)o(5-d)o(ime)o(tho)o(xy)o(-PE)o(A)
  2010. 26 291 y(39)25 b(2C-T)254 b(A)26 b(60-100)49 b(4-Methylt)o(hio)o(-2,)o(5-)o
  2011. (dim)o(eth)o(oxy)o(-P)o(EA)26 351 y(39)25 b(2CT-2ETO)150 b(T)77
  2012. b(50)102 b(2-Ethoxy-)o(5-m)o(eth)o(ox)o(y-4)o(-me)o(thy)o(lt)o(hio)o(-PE)o(A)
  2013. 26 411 y(39)25 b(2CT-5ETO)150 b(A)77 b(30)102 b(5-Ethoxy-)o(2-m)o(eth)o(ox)o
  2014. (y-4)o(-me)o(thy)o(lt)o(hio)o(-PE)o(A)26 471 y(40)25 b(2C-T-2)202
  2015. b(A)51 b(12-25)f(4-Ethylth)o(io-)o(2,5)o(-d)o(ime)o(tho)o(xy-)o(PE)o(A)26
  2016. 531 y(40)25 b(2CT2-2ETO)124 b(A)77 b(50)102 b(2-Ethoxy-)o(4-e)o(thy)o(lt)o
  2017. (hio)o(-5-)o(met)o(ho)o(xy-)o(PEA)26 592 y(40)25 b(2CT2-5ETO)124
  2018. b(A)77 b(20)102 b(5-Ethoxy-)o(4-e)o(thy)o(lt)o(hio)o(-2-)o(met)o(ho)o(xy-)o
  2019. (PEA)26 652 y(40)25 b(2CT2-2,5D)o(IE)o(TO)d(A)51 b(10-50)f(2,5-Dieth)o(oxy)o
  2020. (-4-)o(et)o(hyl)o(thi)o(o-P)o(EA)26 712 y(41)25 b(2C-T-4)202
  2021. b(A)51 b(8-20)76 b(4-Isoprop)o(ylt)o(hio)o(-2)o(,5-)o(dim)o(eth)o(ox)o(y-P)o
  2022. (EA)26 772 y(41)25 b(2CT4-2ETO)124 b(A)51 b(10-25)f(2-Ethoxy-)o(5-m)o(eth)o
  2023. (ox)o(y-4)o(-\(i)o(\)-p)o(ro)o(pyl)o(thi)o(o-P)o(EA)26 832
  2024. y(42)25 b(pseudo-2C)o(-T)o(-4)d(T)51 b(8-12)76 b(4-Isoprop)o(ylt)o(hio)o(-2)o
  2025. (,6-)o(dim)o(eth)o(ox)o(y-P)o(EA)26 892 y(43)25 b(2C-T-7)202
  2026. b(A)51 b(10-30)f(4-Propylt)o(hio)o(-2,)o(5-)o(dim)o(eth)o(oxy)o(-P)o(EA)26
  2027. 953 y(43)25 b(2CT7-2ETO)124 b(A)77 b(20)102 b(2-Ethoxy-)o(5-m)o(eth)o(ox)o
  2028. (y-4)o(-\(n)o(\)-p)o(ro)o(pyl)o(thi)o(o-P)o(EA)26 1013 y(43)25
  2029. b(METHYL-2C)o(-T)o(-7)d(U)231 b(2,5-Dimet)o(hox)o(y-4)o(-\()o(n\)-)o(pro)o
  2030. (pyl)o(-N)o(-me)o(thy)o(l-P)o(EA)26 1073 y(44)25 b(2C-T-8)202
  2031. b(A)51 b(30-50)f(4-Cyclopr)o(opy)o(lme)o(th)o(ylt)o(hio)o(-2,)o(5-)o(dii)o
  2032. (met)o(hox)o(y-)o(PEA)26 1133 y(45)25 b(2C-T-9)202 b(A)26 b(60-100)49
  2033. b(4-\(t\)-But)o(ylt)o(hio)o(-2)o(,5-)o(dim)o(eth)o(ox)o(y-P)o(EA)26
  2034. 1193 y(46)25 b(2C-T-13)176 b(A)51 b(25-40)f(4-\(2-Meth)o(oxy)o(eth)o(yl)o
  2035. (thi)o(o\)-)o(2,5)o(-d)o(ime)o(tho)o(xy-)o(PE)o(A)26 1254 y(47)25
  2036. b(2C-T-15)176 b(T)77 b(30)102 b(4-Cyclopr)o(opy)o(lth)o(io)o(-2,)o(5-d)o(ime)
  2037. o(th)o(oxy)o(-PE)o(A)26 1314 y(48)25 b(2C-T-17)176 b(A)26 b(60-100)49
  2038. b(4-\(s\)-But)o(ylt)o(hio)o(-2)o(,5-)o(dim)o(eth)o(ox)o(y-P)o(EA)26
  2039. 1374 y(49)25 b(2C-T-21)176 b(A)51 b(8-12)76 b(4-\(2-Fluo)o(roe)o(thy)o(lt)o
  2040. (hio)o(\)-2)o(,5-)o(di)o(met)o(hox)o(y-P)o(EA)26 1434 y(50)25
  2041. b(4-D)280 b(A)26 b(200-400)d(4-Trideut)o(ero)o(met)o(hy)o(l-3)o(,5-)o(dim)o
  2042. (et)o(hox)o(y-P)o(EA)26 1494 y(51)i(beta-D)202 b(A)26 b(200-400)d(beta,beta)o
  2043. (-Di)o(deu)o(te)o(ro-)o(3,4)o(,5-)o(tr)o(ime)o(tho)o(xy-)o(PE)o(A)26
  2044. 1555 y(52)i(DESOXY)202 b(T)26 b(40-120)49 b(4-Me-3,5-)o(Dim)o(eth)o(ox)o(y-P)
  2045. o(EA)26 1615 y(53)25 b(2,4-DMA)176 b(T)77 b(60)102 b(2,4-Dimet)o(hox)o(y-A)26
  2046. 1675 y(54)25 b(2,5-DMA)176 b(P)26 b(80-160)49 b(2,5-Dimet)o(hox)o(y-A)26
  2047. 1735 y(54)25 b(?)332 b(S)77 b(150)f(2,5-Dimet)o(hyl)o(-A)26
  2048. 1795 y(54)25 b(?)332 b(O)77 b(10)102 b(3,4-Dimet)o(hyl)o(-A)26
  2049. 1856 y(54)25 b(?)332 b(O)26 b(75-150)49 b(2-Methyl-)o(A)26
  2050. 1916 y(54)25 b(?)332 b(O)26 b(75-150)49 b(3-Methyl-)o(A)26
  2051. 1976 y(54)25 b(?)332 b(P)26 b(75-150)49 b(4-Methyl-)o(A)26
  2052. 2036 y(54)25 b(2,5-DNNA)150 b(U)231 b(2,5-Dimet)o(hox)o(y-N)o(,N)o(-di)o(met)
  2053. o(hyl)o(-A)26 2096 y(54)25 b(IDNNA)228 b(U)j(4-Iodo-2,)o(5-d)o(ime)o(th)o
  2054. (oxy)o(-N,)o(N-d)o(im)o(eth)o(yl-)o(A)26 2156 y(54)25 b(FDNNA)228
  2055. b(U)j(4-Fluoro-)o(2,5)o(-di)o(me)o(tho)o(xy-)o(N,N)o(-d)o(ime)o(thy)o(l-A)26
  2056. 2217 y(54)25 b(2,5-DMNNA)124 b(U)231 b(2,5,N,N-T)o(etr)o(ame)o(th)o(yl-)o(A)
  2057. 26 2277 y(54)25 b(?)332 b(U)231 b(4-Fluoro-)o(2,5)o(,N,)o(N-)o(tet)o(ram)o
  2058. (eth)o(yl)o(-A)26 2337 y(55)25 b(3,4-DMA)176 b(A)51 b(>160)76
  2059. b(3,4-Dimet)o(hox)o(y-A)26 2397 y(55)25 b(2,6-DNNA)150 b(U)231
  2060. b(2,6-Dimet)o(hox)o(y-N)o(,N)o(-di)o(met)o(hyl)o(-A)26 2457
  2061. y(55)25 b(3,5-DNNA)150 b(U)231 b(3,5-Dimet)o(hox)o(y-N)o(,N)o(-di)o(met)o
  2062. (hyl)o(-A)26 2518 y(56)25 b(DMCPA)228 b(A)51 b(15-20)f(2-\(2,5-Di)o(met)o
  2063. (hox)o(y-)o(4-m)o(eth)o(ylp)o(he)o(nyl)o(\)-c)o(ycl)o(op)o(rop)o(yla)o(mi)o
  2064. (ne)26 2578 y(56)25 b(TMT)280 b(S)77 b(13)102 b(Trans-2-\()o(3,4)o(,5-)o(tr)o
  2065. (ime)o(tho)o(xyp)o(he)o(nyl)o(\)cy)o(clo)o(pr)o(opy)o(lam)o(in)o(e)26
  2066. 2638 y(57)25 b(DME)280 b(S)77 b(115)f(3,4-Dimet)o(hox)o(y-b)o(et)o(a-h)o(ydr)
  2067. o(oxy)o(-P)o(EA)26 2698 y(57)25 b(BOHH)254 b(S)77 b(100)f(3,4-Methy)o(len)o
  2068. (edi)o(ox)o(y-b)o(eta)o(-hy)o(dr)o(oxy)o(-PE)o(A)951 2825 y
  2069. Fk(31)p eop
  2070. %%Page: 32 32
  2071. bop 26 50 a Fa(58)25 b(DMMDA)228 b(A)51 b(30-75)f(2,5-Dimet)o(hox)o(y-3)o(,4)
  2072. o(-me)o(thy)o(len)o(ed)o(iox)o(y-A)26 110 y(58)25 b(?)332 b(T)77
  2073. b(80)102 b(threo-2-A)o(min)o(o-3)o(-\()o(2,5)o(-di)o(met)o(ho)o(xy-)o(3,4)o
  2074. (-MD)o(P\))o(but)o(ane)26 170 y(58)25 b(?)332 b(S)77 b(10)102
  2075. b(erythro-2)o(-Am)o(ino)o(-3)o(-\(2)o(,5-)o(dim)o(et)o(hox)o(y-3)o(,4-)o(MD)o
  2076. (P\)b)o(uta)o(ne)26 230 y(59)25 b(DMMDA-2)176 b(A)77 b(50)102
  2077. b(2,3-Dimet)o(hox)o(y-4)o(,5)o(-me)o(thy)o(len)o(ed)o(iox)o(y-A)26
  2078. 291 y(60)25 b(DMPEA)228 b(N)51 b(1000)76 b(3,4-Dimet)o(hox)o(y-P)o(EA)26
  2079. 351 y(60)25 b(?)332 b(N)77 b(500)f(N-Acetyl-)o(3,4)o(-di)o(me)o(tho)o(xy-)o
  2080. (PEA)26 411 y(61)25 b(DOAM)254 b(T)77 b(10)102 b(4-Amyl-2,)o(5-d)o(ime)o(th)o
  2081. (oxy)o(-A)26 471 y(62)25 b(DOB)280 b(A)77 b(1-3)f(4-Bromo-2)o(,5-)o(dim)o(et)
  2082. o(hox)o(y-A)26 531 y(63)25 b(DOBU)254 b(T)77 b(2.8)f(4-Butyl-2)o(,5-)o(dim)o
  2083. (et)o(hox)o(y-A)26 592 y(63)25 b(DOIB)254 b(A)51 b(10-15)f(2,5-Dimet)o(hox)o
  2084. (y-4)o(-\()o(2-m)o(eth)o(ylp)o(ro)o(pyl)o(\)-A)26 652 y(63)25
  2085. b(DOSB)254 b(A)51 b(25-30)f(2,5-Dimet)o(hox)o(y-4)o(-\()o(1,1)o(-di)o(met)o
  2086. (hy)o(let)o(hyl)o(\)-A)26 712 y(63)25 b(DOTB)254 b(S)77 b(25)102
  2087. b(2,5-Dimet)o(hox)o(y-4)o(-\()o(1-m)o(eth)o(ylp)o(ro)o(pyl)o(\)-A)26
  2088. 772 y(64)25 b(DOC)280 b(A)51 b(1.5-3)f(4-Chloro-)o(2,5)o(-di)o(me)o(tho)o
  2089. (xy-)o(A)26 832 y(64)25 b(DOA)280 b(U)231 b(2,5-dimet)o(hox)o(y-4)o(-a)o(min)
  2090. o(o-A)26 892 y(64)25 b(DOAA)254 b(U)231 b(2,5-dimet)o(hox)o(y-4)o(-a)o(cet)o
  2091. (ami)o(do-)o(A)26 953 y(65)25 b(DOEF)254 b(A)51 b(2-3.5)f(4-\(2-Fluo)o(roe)o
  2092. (thy)o(l\))o(-2,)o(5-d)o(ime)o(th)o(oxy)o(-A)26 1013 y(66)25
  2093. b(DOET)254 b(A)77 b(2-6)f(4-Ethyl-2)o(,5-)o(dim)o(et)o(hox)o(y-A)26
  2094. 1073 y(67)25 b(DOI)280 b(A)51 b(1.5-3)f(4-Iodo-2,)o(5-d)o(ime)o(th)o(oxy)o
  2095. (-A)26 1133 y(67)25 b(?)332 b(S)103 b(4)f(1-\(2,5-di)o(met)o(hox)o(y-)o(4-i)o
  2096. (odo)o(phe)o(ny)o(l\)-)o(2-a)o(min)o(ob)o(uta)o(ne)26 1193
  2097. y(68)25 b(DOM)280 b(A)51 b(3-10)76 b(4-Methyl-)o(2,5)o(-di)o(me)o(tho)o(xy-)o
  2098. (A)26 1254 y(68)25 b(5-DOM)228 b(S)77 b(20)102 b(2,4-Dimet)o(hox)o(y-5)o(-m)o
  2099. (eth)o(yl-)o(A)26 1314 y(68)25 b(2-DOM)228 b(U)j(4,5-Dimet)o(hox)o(y-2)o(-m)o
  2100. (eth)o(yl-)o(A)26 1374 y(69)25 b(pseudo-DO)o(M)99 b(A)51 b(15-25)f(4-Methyl-)
  2101. o(2,6)o(-di)o(me)o(tho)o(xy-)o(A)26 1434 y(69)25 b(Z-7.1)228
  2102. b(?)j(2,4-Dimet)o(hox)o(y-6)o(-m)o(eth)o(yl-)o(A)26 1494 y(69)25
  2103. b(Z-7.2)228 b(U)j(4-Methyl-)o(2,3)o(,6-)o(tr)o(ime)o(tho)o(xy-)o(A)26
  2104. 1555 y(70)25 b(DON)280 b(A)51 b(3-4.5)f(4-Nitro-2)o(,5-)o(dim)o(et)o(hox)o
  2105. (y-A)26 1615 y(71)25 b(DOPR)254 b(A)51 b(2.5-5)f(4-Propyl-)o(2,5)o(-di)o(me)o
  2106. (tho)o(xy-)o(A)26 1675 y(71)25 b(hydroxy-D)o(OP)o(R)48 b(S)77
  2107. b(0.2)f(2,5-Dimet)o(hox)o(y-4)o(-\()o(1-h)o(ydr)o(oxy)o(pr)o(opy)o(l\)-)o(A)
  2108. 26 1735 y(71)25 b(DOIP)254 b(T)51 b(20-30)f(2,5-Dimet)o(hox)o(y-4)o(-\()o
  2109. (i\)-)o(pro)o(pyl)o(-A)26 1795 y(72)25 b(E)332 b(A)51 b(40-60)f(4-Ethoxy-)o
  2110. (3,5)o(-di)o(me)o(tho)o(xy-)o(PEA)26 1856 y(73)25 b(EEE)280
  2111. b(U)231 b(2,4,5-Tri)o(eth)o(oxy)o(-A)26 1916 y(74)25 b(EEM)280
  2112. b(U)231 b(2,4-Dieth)o(oxy)o(-5-)o(me)o(tho)o(xy-)o(A)26 1976
  2113. y(75)25 b(EME)280 b(U)231 b(2,5-Dieth)o(oxy)o(-4-)o(me)o(tho)o(xy-)o(A)26
  2114. 2036 y(76)25 b(EMM)280 b(S)77 b(50)102 b(2-Ethoxy-)o(4,5)o(-di)o(me)o(tho)o
  2115. (xy-)o(A)26 2096 y(77)25 b(ETHYL-J)176 b(T)77 b(90)102 b(N,alpha-d)o(iet)o
  2116. (hyl)o(-3)o(,4-)o(met)o(hyl)o(en)o(edi)o(oxy)o(-PE)o(A)26 2156
  2117. y(78)25 b(ETHYL-K)176 b(S)77 b(40)102 b(N-Ethyl-a)o(lph)o(a-p)o(ro)o(pyl)o
  2118. (-3,)o(4-m)o(et)o(hyl)o(ene)o(dio)o(xy)o(-PE)o(A)26 2217 y(79)25
  2119. b(F-2)280 b(S)77 b(15)102 b(Benzofura)o(n-2)o(-me)o(th)o(yl-)o(5-m)o(eth)o
  2120. (ox)o(y-6)o(-\(2)o(-am)o(in)o(opr)o(opa)o(ne)o(\))26 2277 y(79)25
  2121. b(F)332 b(S)77 b(30)102 b(Benzofura)o(n-2)o(,3-)o(di)o(hyd)o(ro-)o(5-m)o(et)o
  2122. (hox)o(y-6)o(-\(2)o(-a)o(min)o(opr)o(op)o(ane)o(\))26 2337
  2123. y(80)25 b(F-22)254 b(S)77 b(15)102 b(Benzofura)o(n-2)o(,2-)o(di)o(met)o(hyl)o
  2124. (-5-)o(me)o(tho)o(xy-)o(6-\()o(2-)o(ami)o(nop)o(ro)o(pan)o(e\))26
  2125. 2397 y(81)25 b(FLEA)254 b(A)26 b(100-160)d(N-Hydroxy)o(-N-)o(met)o(hy)o(l-3)o
  2126. (,4-)o(met)o(hy)o(len)o(e-A)26 2457 y(82)i(G-3)280 b(A)51 b(12-18)f
  2127. (3,4-Trime)o(thy)o(len)o(e-)o(2,5)o(-di)o(met)o(ho)o(xy-)o(A)26
  2128. 2518 y(83)25 b(G-4)280 b(I)231 b(3,4-Tetra)o(met)o(hyl)o(en)o(e-2)o(,5-)o
  2129. (dim)o(et)o(hox)o(y-A)26 2578 y(84)25 b(G-5)280 b(A)51 b(14-20)f(3,4-Norbo)o
  2130. (rny)o(l-2)o(,5)o(-di)o(met)o(hox)o(y-)o(A)26 2638 y(85)25
  2131. b(GANESHA)176 b(A)51 b(20-32)f(3,4-Dimet)o(hyl)o(-2,)o(5-)o(dim)o(eth)o(oxy)o
  2132. (-A)26 2698 y(86)25 b(G-N)280 b(S)103 b(2)f(1,4-Dimet)o(hox)o(yna)o(ph)o(thy)
  2133. o(l-2)o(-is)o(op)o(rop)o(yla)o(min)o(e)951 2825 y Fk(32)p eop
  2134. %%Page: 33 33
  2135. bop 26 50 a Fa(87)25 b(HOT-2)228 b(A)51 b(10-18)f(2,5-Dimet)o(hox)o(y-N)o(-h)
  2136. o(ydr)o(oxy)o(-4-)o(et)o(hyl)o(thi)o(o-P)o(EA)26 110 y(88)25
  2137. b(HOT-7)228 b(A)51 b(15-25)f(2,5-Dimet)o(hox)o(y-N)o(-h)o(ydr)o(oxy)o(-4-)o
  2138. (\(n)o(\)-p)o(rop)o(ylt)o(hi)o(o-P)o(EA)26 170 y(89)25 b(HOT-17)202
  2139. b(A)26 b(70-120)49 b(2,5-Dimet)o(hox)o(y-N)o(-h)o(ydr)o(oxy)o(-4-)o(\(s)o
  2140. (\)-b)o(uty)o(lth)o(io)o(-PE)o(A)26 230 y(90)25 b(IDNNA)228
  2141. b(S)77 b(2.6)f(2,5-Dimet)o(hox)o(y-N)o(,N)o(-di)o(met)o(hyl)o(-4)o(-io)o(do-)
  2142. o(A)26 291 y(90)25 b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-N)o(-b)o(enz)o(yl-)o
  2143. (4-i)o(od)o(o-A)26 351 y(90)25 b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-N)o(-b)o
  2144. (enz)o(yl-)o(4-i)o(od)o(o-N)o(-me)o(thy)o(l-)o(A)26 411 y(90)25
  2145. b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-N)o(-c)o(yan)o(ome)o(thy)o(l-)o(4-i)o
  2146. (odo)o(-A)26 471 y(90)25 b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-N)o(-c)o(ycl)o
  2147. (opr)o(opy)o(lm)o(eth)o(yl-)o(4-i)o(od)o(o-A)26 531 y(90)25
  2148. b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-N)o(,N)o(-di)o(eth)o(yl-)o(A)26
  2149. 592 y(90)25 b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-N)o(,N)o(-di)o(eth)o(yl-)o
  2150. (4-)o(iod)o(o-A)26 652 y(90)25 b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-N)o(-\()
  2151. o(3-d)o(ime)o(thy)o(la)o(min)o(opr)o(opy)o(l\))o(-4-)o(iod)o(o-)o(A)26
  2152. 712 y(90)25 b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-N)o(,N)o(-di)o(met)o(hyl)o
  2153. (-4)o(-io)o(do-)o(A)26 772 y(90)25 b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-N)o
  2154. (-d)o(ode)o(cyl)o(-4-)o(io)o(do-)o(A)26 832 y(90)25 b(?)332
  2155. b(U)231 b(2,5-Dimet)o(hox)o(y-N)o(-\()o(n\)-)o(hex)o(yl-)o(4-)o(iod)o(o-A)26
  2156. 892 y(90)25 b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-4)o(-i)o(odo)o(-N-)o(met)o
  2157. (hy)o(l-A)26 953 y(90)25 b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-4)o(-i)o(odo)o
  2158. (-N-)o(met)o(hy)o(l-N)o(-\(i)o(\)-p)o(ro)o(pyl)o(-A)26 1013
  2159. y(90)25 b(?)332 b(U)231 b(2,5-Dimet)o(hox)o(y-4)o(-i)o(odo)o(-N-)o(\(i\))o
  2160. (-p)o(rop)o(yl-)o(A)26 1073 y(91)25 b(IM)306 b(N)77 b(400)f(2,3,4-Tri)o(met)o
  2161. (hox)o(y-)o(PEA)26 1133 y(92)25 b(IP)306 b(A)51 b(40-80)f(3,5-Dimet)o(hox)o
  2162. (y-4)o(-i)o(sop)o(rop)o(oxy)o(-P)o(EA)26 1193 y(93)25 b(IRIS)254
  2163. b(S)103 b(9)f(5-Ethoxy-)o(2-m)o(eth)o(ox)o(y-4)o(-me)o(thy)o(l-)o(A)26
  2164. 1254 y(94)25 b(J)332 b(A)26 b(150-230)d(alpha-Eth)o(yl-)o(3,4)o(-m)o(eth)o
  2165. (yle)o(ned)o(io)o(xy-)o(PEA)26 1314 y(95)i(LOPHOPHIN)o(E)99
  2166. b(S)77 b(250)f(3-Methoxy)o(-4,)o(5-m)o(et)o(hyl)o(ene)o(dio)o(xy)o(-PE)o(A)26
  2167. 1374 y(96)25 b(M)332 b(A)26 b(200-400)d(3,4,5-Tri)o(met)o(hox)o(y-)o(PEA)26
  2168. 1434 y(96)i(?)332 b(N)26 b(300-750)d(N-Acetyl-)o(3,4)o(,5-)o(tr)o(ime)o(tho)o
  2169. (xy-)o(PE)o(A)26 1494 y(96)i(?)332 b(S)77 b(25)102 b(N-Methyl-)o(3,4)o(,5-)o
  2170. (tr)o(ime)o(tho)o(xy-)o(PE)o(A)26 1555 y(96)25 b(?)332 b(N)77
  2171. b(500)f(N,N-Dimet)o(hyl)o(-3,)o(4,)o(5-t)o(rim)o(eth)o(ox)o(y-P)o(EA)26
  2172. 1615 y(96)25 b(TMPEA)228 b(N)77 b(750)f(3,4,5-Tri)o(met)o(hox)o(yp)o(hen)o
  2173. (yla)o(cet)o(ic)22 b(acid)26 1675 y(96)j(?)332 b(N)26 b(10-300)49
  2174. b(2-\(3,4,5-)o(Tri)o(met)o(ho)o(xyp)o(hen)o(oxy)o(\)e)o(thy)o(lam)o(ine)26
  2175. 1735 y(96)25 b(?)332 b(N)26 b(10-400)49 b(N,N-Dimet)o(hyl)o(-2-)o(\(3)o(,4,)o
  2176. (5-t)o(rim)o(et)o(hox)o(yph)o(eno)o(xy)o(\)et)o(hyl)o(am)o(ine)26
  2177. 1795 y(97)25 b(4-MA)254 b(P)51 b(50-80)f(4-Methoxy)o(-A)26
  2178. 1856 y(97)25 b(2-MA)254 b(U)231 b(2-Methoxy)o(-A)26 1916 y(97)25
  2179. b(3-MA)254 b(S)77 b(50)102 b(3-Methoxy)o(-A)26 1976 y(97)25
  2180. b(Orthoxine)124 b(O)77 b(200)f(N-Methyl-)o(2-m)o(eth)o(ox)o(y-A)26
  2181. 2036 y(98)25 b(MADAM-6)176 b(N)77 b(280)f(2,N-Dimet)o(hyl)o(-4,)o(5-)o(met)o
  2182. (hyl)o(ene)o(di)o(oxy)o(-A)26 2096 y(99)25 b(MAL)280 b(A)51
  2183. b(40-65)f(3,5-Dimet)o(hox)o(y-4)o(-m)o(eth)o(all)o(ylo)o(xy)o(-PE)o(A)0
  2184. 2156 y(100)25 b(MDA)280 b(A)26 b(80-160)49 b(3,4-Methy)o(len)o(edi)o(ox)o
  2185. (y-A)0 2217 y(100)25 b(ALPHA)228 b(A)26 b(10-140)49 b(1-Amino-1)o(-\(3)o(,4-)
  2186. o(me)o(thy)o(len)o(edi)o(ox)o(yph)o(eny)o(l\)p)o(ro)o(pan)o(e)0
  2187. 2277 y(100)25 b(M-ALPHA)176 b(A)77 b(60)102 b(1-Methyla)o(min)o(o-1)o(-\()o
  2188. (3,4)o(-me)o(thy)o(le)o(ned)o(iox)o(yph)o(en)o(yl\))o(pro)o(pa)o(ne)0
  2189. 2337 y(100)25 b(GAMMA)228 b(T)77 b(200)f(1-Amino-3)o(-\(3)o(,4-)o(me)o(thy)o
  2190. (len)o(edi)o(ox)o(yph)o(eny)o(l\)p)o(ro)o(pan)o(e)0 2397 y(100)25
  2191. b(EDA)280 b(T)77 b(150)f(3,4-Ethyl)o(ide)o(ned)o(io)o(xy-)o(A)0
  2192. 2457 y(100)25 b(IDA)280 b(U)231 b(3,4-Isopr)o(opy)o(lid)o(en)o(edi)o(oxy)o
  2193. (-A)0 2518 y(100)25 b(ORTHO-MDA)124 b(O)77 b(50)102 b(2,3-Methy)o(len)o(edi)o
  2194. (ox)o(y-A)0 2578 y(101)25 b(MDAL)254 b(S)77 b(180)f(N-Allyl-3)o(,4-)o(met)o
  2195. (hy)o(len)o(edi)o(oxy)o(-A)0 2638 y(102)25 b(MDBU)254 b(S)77
  2196. b(40)102 b(N-Butyl-3)o(,4-)o(met)o(hy)o(len)o(edi)o(oxy)o(-A)0
  2197. 2698 y(103)25 b(MDBZ)254 b(S)77 b(150)f(N-Benzyl-)o(3,4)o(-me)o(th)o(yle)o
  2198. (ned)o(iox)o(y-)o(A)951 2825 y Fk(33)p eop
  2199. %%Page: 34 34
  2200. bop 0 50 a Fa(103)25 b(MDIB)254 b(U)231 b(3,4-Methy)o(len)o(edi)o(ox)o(y-N)o
  2201. (-\(i)o(\)-b)o(ut)o(yl-)o(A)0 110 y(103)25 b(MDTB)254 b(U)231
  2202. b(3,4-Methy)o(len)o(edi)o(ox)o(y-N)o(-\(t)o(\)-b)o(ut)o(yl-)o(A)0
  2203. 170 y(103)25 b(MDAM)254 b(U)231 b(3,4-Methy)o(len)o(edi)o(ox)o(y-N)o(-am)o
  2204. (yl-)o(A)0 230 y(103)25 b(MDHE)254 b(U)231 b(3,4-Methy)o(len)o(edi)o(ox)o
  2205. (y-N)o(-\(n)o(\)-h)o(ex)o(yl-)o(A)0 291 y(103)25 b(MDOC)254
  2206. b(U)231 b(3,4-Methy)o(len)o(edi)o(ox)o(y-N)o(-\(n)o(\)-o)o(ct)o(yl-)o(A)0
  2207. 351 y(103)25 b(MDDE)254 b(U)231 b(3,4-Methy)o(len)o(edi)o(ox)o(y-N)o(,N-)o
  2208. (die)o(th)o(yl-)o(A)0 411 y(103)25 b(MDCM)254 b(U)231 b(3,4-Methy)o(len)o
  2209. (edi)o(ox)o(y-N)o(-cy)o(ano)o(me)o(thy)o(l-A)0 471 y(103)25
  2210. b(MDBA)254 b(U)231 b(3,4-Methy)o(len)o(edi)o(ox)o(y-N)o(-\(t)o(\)-b)o(ut)o
  2211. (yla)o(min)o(o-A)0 531 y(104)25 b(MDCPM)228 b(S)77 b(10)102
  2212. b(N-Cyclopr)o(opy)o(lme)o(th)o(yl-)o(3,4)o(-me)o(th)o(yle)o(ned)o(iox)o(y-)o
  2213. (A)0 592 y(105)25 b(MDDM)254 b(S)77 b(150)f(N,N-Dimet)o(hyl)o(-3,)o(4-)o(met)
  2214. o(hyl)o(ene)o(di)o(oxy)o(-A)0 652 y(106)25 b(MDE)280 b(A)26
  2215. b(100-200)d(N-Ethyl-3)o(,4-)o(met)o(hy)o(len)o(edi)o(oxy)o(-A)0
  2216. 712 y(106)i(?)332 b(T)77 b(500)f(3,4-methy)o(len)o(edi)o(xo)o(y-N)o(-\(2)o
  2217. (,2,)o(2-)o(tri)o(flu)o(oro)o(et)o(hyl)o(\)-A)0 772 y(107)25
  2218. b(MDHOET)202 b(S)77 b(50)102 b(N-\(2-Hydr)o(oxy)o(eth)o(yl)o(\)-3)o(,4-)o
  2219. (met)o(hy)o(len)o(edi)o(oxy)o(-A)0 832 y(108)25 b(MDIP)254
  2220. b(T)77 b(250)f(N-Isoprop)o(yl-)o(3,4)o(-m)o(eth)o(yle)o(ned)o(io)o(xy-)o(A)0
  2221. 892 y(109)25 b(MDMA)254 b(A)26 b(80-150)49 b(N-Methyl-)o(3,4)o(-me)o(th)o
  2222. (yle)o(ned)o(iox)o(y-)o(A)0 953 y(110)25 b(MDMC)254 b(T)26
  2223. b(150-250)d(N-Methyl-)o(3,4)o(-et)o(hy)o(len)o(edi)o(oxy)o(-A)0
  2224. 1013 y(111)i(MDMEO)228 b(S)77 b(180)f(N-Methoxy)o(-3,)o(4-m)o(et)o(hyl)o(ene)
  2225. o(dio)o(xy)o(-A)0 1073 y(112)25 b(MDMEOET)176 b(S)77 b(180)f(N-\(2-Meth)o
  2226. (oxy)o(eth)o(yl)o(\)-3)o(,4-)o(met)o(hy)o(len)o(edi)o(oxy)o(-A)0
  2227. 1133 y(113)25 b(MDMP)254 b(T)77 b(110)f(alpha,alp)o(ha,)o(N-T)o(ri)o(met)o
  2228. (hyl)o(-3,)o(4-)o(met)o(hyl)o(ene)o(di)o(oxy)o(-PE)o(A)0 1193
  2229. y(114)25 b(MDOH)254 b(A)26 b(100-160)d(N-Hydroxy)o(-3,)o(4-m)o(et)o(hyl)o
  2230. (ene)o(dio)o(xy)o(-A)0 1254 y(115)i(MDPEA)228 b(N)77 b(300)f(3,4-Methy)o(len)
  2231. o(edi)o(xo)o(y-P)o(EA)0 1314 y(115)25 b(METHYL-MD)o(PE)o(A)48
  2232. b(O)77 b(30)102 b(N-Methyl-)o(3,4)o(-me)o(th)o(yle)o(ned)o(ixo)o(y-)o(PEA)0
  2233. 1374 y(116)25 b(MDPH)254 b(A)26 b(160-240)d(alpha,alp)o(ha-)o(Dim)o(et)o(hyl)
  2234. o(-3,)o(4-m)o(et)o(hyl)o(ene)o(dio)o(xy)o(-PE)o(A)0 1434 y(117)i(MDPL)254
  2235. b(S)77 b(150)f(N-Proparg)o(yl-)o(3,4)o(-m)o(eth)o(yle)o(ned)o(io)o(xy-)o(A)0
  2236. 1494 y(118)25 b(MDPR)254 b(N)77 b(200)f(N-Propyl-)o(3,4)o(-me)o(th)o(yle)o
  2237. (ned)o(iox)o(y-)o(A)0 1555 y(119)25 b(ME)306 b(A)26 b(200-350)d(3,4-Dimet)o
  2238. (hox)o(y-5)o(-e)o(tho)o(xy-)o(PEA)0 1615 y(120)i(MEDA)254 b(N)77
  2239. b(200)f(3,4-Ethyl)o(ene)o(dio)o(xy)o(-5-)o(met)o(hox)o(y-)o(A)0
  2240. 1675 y(120)25 b(MTDA)254 b(S)103 b(8)f(3-Methoxy)o(-4,)o(5-t)o(ri)o(met)o
  2241. (hyl)o(ene)o(di)o(oxy)o(-A)0 1735 y(121)25 b(MEE)280 b(S)77
  2242. b(4.6)f(2-Methoxy)o(-4,)o(5-d)o(ie)o(tho)o(xy-)o(A)0 1795 y(122)25
  2243. b(MEM)280 b(A)51 b(20-50)f(2,5-Dimet)o(hox)o(y-4)o(-e)o(tho)o(xy-)o(A)0
  2244. 1856 y(123)25 b(MEPEA)228 b(A)77 b(300)f(3-Methoxy)o(-4-)o(eth)o(ox)o(y-P)o
  2245. (EA)0 1916 y(124)25 b(META-DOB)150 b(T)26 b(50-100)49 b(5-Bromo-2)o(,4-)o
  2246. (dim)o(et)o(hox)o(y-A)0 1976 y(124)25 b(ORTHO-DOB)124 b(U)231
  2247. b(2-Bromo-4)o(,5-)o(dim)o(et)o(hox)o(y-A)0 2036 y(125)25 b(META-DOT)150
  2248. b(T)77 b(35)102 b(5-Methylt)o(hio)o(-2,)o(4-)o(dim)o(eth)o(oxy)o(-A)0
  2249. 2096 y(126)25 b(METHYL-DM)o(A)99 b(T)77 b(250)f(N-Methyl-)o(2,5)o(-di)o(me)o
  2250. (tho)o(xy-)o(A)0 2156 y(126)25 b(METHYL-TM)o(A)99 b(T)77 b(240)f(N-Methyl-)o
  2251. (3,4)o(,5-)o(tr)o(ime)o(tho)o(xy-)o(A)0 2217 y(126)25 b(METHYL-TM)o(A-)o(2)48
  2252. b(S)77 b(120)f(N-Methyl-)o(2,4)o(,5-)o(tr)o(ime)o(tho)o(xy-)o(A)0
  2253. 2277 y(126)25 b(METHYL-TM)o(A-)o(6)48 b(S)77 b(30)102 b(N-Methyl-)o(2,4)o
  2254. (,6-)o(tr)o(ime)o(tho)o(xy-)o(A)0 2337 y(127)25 b(METHYL-DO)o(B)99
  2255. b(P)k(8)f(4-Bromo-2)o(,5-)o(dim)o(et)o(hox)o(y-N)o(-me)o(th)o(yl-)o(A)0
  2256. 2397 y(128)25 b(METHYL-J)150 b(A)26 b(180-210)d(N-Methyl-)o(alp)o(ha-)o(et)o
  2257. (hyl)o(-3,)o(4-m)o(et)o(hyl)o(ene)o(dio)o(xy)o(-PE)o(A)0 2457
  2258. y(129)i(METHYL-K)150 b(S)77 b(100)f(N-Methyl-)o(alp)o(ha-)o(pr)o(opy)o(l-3)o
  2259. (,4-)o(me)o(thy)o(len)o(edi)o(ox)o(y-P)o(EA)0 2518 y(129)25
  2260. b(K)332 b(U)231 b(2-Amino-1)o(-\(3)o(,4-)o(me)o(thy)o(len)o(edi)o(ox)o(yph)o
  2261. (eny)o(l\)p)o(en)o(tan)o(e)0 2578 y(129)25 b(L)332 b(U)231
  2262. b(2-Amino-1)o(-\(3)o(,4-)o(me)o(thy)o(len)o(edi)o(ox)o(yph)o(eny)o(l\)h)o(ex)
  2263. o(ane)0 2638 y(129)25 b(METHYL-L)150 b(U)231 b(2-Methyla)o(min)o(o-1)o(-\()o
  2264. (3,4)o(-me)o(thy)o(le)o(ned)o(iox)o(yph)o(en)o(yl\))o(hex)o(an)o(e)0
  2265. 2698 y(129)25 b(ETHYL-L)176 b(U)231 b(2-Ethylam)o(ino)o(-1-)o(\(3)o(,4-)o
  2266. (met)o(hyl)o(en)o(edi)o(oxy)o(phe)o(ny)o(l\)h)o(exa)o(ne)951
  2267. 2825 y Fk(34)p eop
  2268. %%Page: 35 35
  2269. bop 0 50 a Fa(130)25 b(METHYL-MA)124 b(P)77 b(100)f(N-Methyl-)o(4-m)o(eth)o
  2270. (ox)o(y-A)0 110 y(130)25 b(4-MNNA)202 b(?)231 b(4-Methoxy)o(-N,)o(N-d)o(im)o
  2271. (eth)o(yl-)o(A)0 170 y(130)25 b(2-MNNA)202 b(?)231 b(2-Methoxy)o(-N,)o(N-d)o
  2272. (im)o(eth)o(yl-)o(A)0 230 y(131)25 b(METHYL-MM)o(DA)o(-2)d(S)77
  2273. b(70)102 b(N-Methyl-)o(2-m)o(eth)o(ox)o(y-4)o(,5-)o(met)o(hy)o(len)o(edi)o
  2274. (oxy)o(-A)0 291 y(131)25 b(DMMDMA)202 b(U)231 b(2,5-Dimet)o(hox)o(y-N)o(-m)o
  2275. (eth)o(yl-)o(3,4)o(-m)o(eth)o(yle)o(ned)o(io)o(xy-)o(A)0 351
  2276. y(132)25 b(MMDA)254 b(A)26 b(100-250)d(3-Methoxy)o(-4,)o(5-m)o(et)o(hyl)o
  2277. (ene)o(dio)o(xy)o(-A)0 411 y(133)i(MMDA-2)202 b(A)51 b(25-50)f(2-Methoxy)o
  2278. (-4,)o(5-m)o(et)o(hyl)o(ene)o(dio)o(xy)o(-A)0 471 y(133)25
  2279. b(2C-2)254 b(S)77 b(2.6)f(2-Methoxy)o(-4,)o(5-m)o(et)o(hyl)o(ene)o(dio)o(xy)o
  2280. (-PE)o(A)0 531 y(133)25 b(4C-2)254 b(U)231 b(1-\(2-Meth)o(oxy)o(-4,)o(5-)o
  2281. (met)o(hyl)o(ene)o(di)o(oxy)o(phe)o(nyl)o(\)-)o(2-a)o(min)o(oB)0
  2282. 592 y(133)25 b(EMDA-2)202 b(A)26 b(135-185)d(2-Ethoxy-)o(4,5)o(-me)o(th)o
  2283. (yle)o(ned)o(iox)o(y-)o(A)0 652 y(134)i(MMDA-3a)176 b(A)51
  2284. b(20-80)f(2-Methoxy)o(-3,)o(4-m)o(et)o(hyl)o(ene)o(dio)o(xy)o(-A)0
  2285. 712 y(135)25 b(MMDA-3b)176 b(T)51 b(60-80)f(4-Methoxy)o(-2,)o(3-m)o(et)o(hyl)
  2286. o(ene)o(dio)o(xy)o(-A)0 772 y(135)25 b(MMDA-5)202 b(T)77 b(30)0
  2287. 832 y(136)25 b(MME)280 b(T)77 b(40)102 b(2,4-Dimet)o(hox)o(y-5)o(-e)o(tho)o
  2288. (xy-)o(A)0 892 y(137)25 b(MP)306 b(N)77 b(240)f(3,4-Dimet)o(hox)o(y-5)o(-p)o
  2289. (rop)o(oxy)o(-PE)o(A)0 953 y(138)25 b(MPM)280 b(T)77 b(30)102
  2290. b(2,5-Dimet)o(hox)o(y-4)o(-p)o(rop)o(oxy)o(-A)0 1013 y(138)25
  2291. b(MIPM)254 b(U)231 b(2,5-Dimet)o(hox)o(y-4)o(-\()o(i\)-)o(pro)o(pox)o(y-)o(A)
  2292. 0 1073 y(138)25 b(MBM)280 b(S)77 b(12)102 b(4-\(n\)-But)o(oxy)o(-2,)o(5-)o
  2293. (dim)o(eth)o(oxy)o(-A)0 1133 y(138)25 b(MAM)280 b(S)77 b(12)102
  2294. b(4-\(n\)-Amy)o(l-2)o(,5-)o(di)o(met)o(hox)o(y-A)0 1193 y(139)25
  2295. b(ORTHO-DOT)124 b(S)77 b(25)102 b(2-Methylt)o(hio)o(-4,)o(5-)o(dim)o(eth)o
  2296. (oxy)o(-A)0 1254 y(140)25 b(P)332 b(A)51 b(30-60)f(3,5-Dimet)o(hox)o(y-4)o
  2297. (-p)o(rop)o(oxy)o(-PE)o(A)0 1314 y(141)25 b(PE)306 b(S)77 b(150)f(3,5-Dimet)o
  2298. (hox)o(y-4)o(-p)o(hen)o(eth)o(ylo)o(xy)o(-PE)o(A)0 1374 y(142)25
  2299. b(PEA)280 b(N)51 b(1600)76 b(PEA)0 1434 y(142)25 b(MPEA)254
  2300. b(N)77 b(400)f(4-Methoxy)o(-PE)o(A)0 1494 y(142)25 b(4-Cl-PEA)150
  2301. b(N)77 b(500)f(4-Chloro-)o(PEA)0 1555 y(143)25 b(PROPYNYL)150
  2302. b(T)77 b(80)102 b(4-Propyny)o(lox)o(y-3)o(,5)o(-di)o(met)o(hox)o(y-)o(PEA)0
  2303. 1615 y(144)25 b(SB)306 b(N)77 b(240)f(3,5-Dieth)o(oxy)o(-4-)o(me)o(tho)o(xy-)
  2304. o(PEA)0 1675 y(145)25 b(TA)306 b(T)77 b(35)102 b(2,3,4,5-T)o(etr)o(ame)o(th)o
  2305. (oxy)o(-A)0 1735 y(146)25 b(3-TASB)202 b(A)77 b(160)f(4-Ethoxy-)o(3-e)o(thy)o
  2306. (lt)o(hio)o(-5-)o(met)o(ho)o(xy-)o(PEA)0 1795 y(147)25 b(4-TASB)202
  2307. b(P)26 b(60-100)49 b(3-Ethoxy-)o(4-e)o(thy)o(lt)o(hio)o(-5-)o(met)o(ho)o(xy-)
  2308. o(PEA)0 1856 y(148)25 b(5-TASB)202 b(P)26 b(120-160)d(3,4-Dieth)o(oxy)o(-5-)o
  2309. (me)o(thy)o(lth)o(io-)o(PE)o(A)0 1916 y(149)i(TB)306 b(T)26
  2310. b(60-120)49 b(4-Thiobut)o(oxy)o(-3,)o(5-)o(dim)o(eth)o(oxy)o(-P)o(EA)0
  2311. 1976 y(150)25 b(3-TE)254 b(A)51 b(60-80)f(4-Ethoxy-)o(5-m)o(eth)o(ox)o(y-3)o
  2312. (-me)o(thy)o(lt)o(hio)o(-PE)o(A)0 2036 y(151)25 b(4-TE)254
  2313. b(A)51 b(20-30)f(3,5-Dimet)o(hox)o(y-4)o(-e)o(thy)o(lth)o(io-)o(PE)o(A)0
  2314. 2096 y(152)25 b(2-TIM)228 b(N)77 b(240)f(2-Methylt)o(hio)o(-3,)o(4-)o(dim)o
  2315. (eth)o(oxy)o(-P)o(EA)0 2156 y(153)25 b(3-TIM)228 b(N)77 b(240)f(3-Methylt)o
  2316. (hio)o(-2,)o(4-)o(dim)o(eth)o(oxy)o(-P)o(EA)0 2217 y(154)25
  2317. b(4-TIM)228 b(S)77 b(160)f(4-Methylt)o(hio)o(-2,)o(3-)o(dim)o(eth)o(oxy)o(-P)
  2318. o(EA)0 2277 y(155)25 b(3-TM)254 b(A)26 b(60-100)49 b(3-Methylt)o(hio)o(-4,)o
  2319. (5-)o(dim)o(eth)o(oxy)o(-P)o(EA)0 2337 y(156)25 b(4-TM)254
  2320. b(A)51 b(20-40)f(4-Methylt)o(hio)o(-3,)o(5-)o(dim)o(eth)o(oxy)o(-P)o(EA)0
  2321. 2397 y(157)25 b(TMA)280 b(A)26 b(100-250)d(3,4,5-Tri)o(met)o(hox)o(y-)o(A)0
  2322. 2457 y(158)i(TMA-2)228 b(A)51 b(20-40)f(2,4,5-Tri)o(met)o(hox)o(y-)o(A)0
  2323. 2518 y(159)25 b(TMA-3)228 b(S)77 b(100)f(2,3,4-Tri)o(met)o(hox)o(y-)o(A)0
  2324. 2578 y(160)25 b(TMA-4)228 b(A)77 b(80)102 b(2,3,5-Tri)o(met)o(hox)o(y-)o(A)0
  2325. 2638 y(161)25 b(TMA-5)228 b(A)77 b(30)102 b(2,3,6-Tri)o(met)o(hox)o(y-)o(A)0
  2326. 2698 y(161)25 b(2C-TMA-5)150 b(U)231 b(2,3,6-Tri)o(met)o(hox)o(y-)o(PEA)951
  2327. 2825 y Fk(35)p eop
  2328. %%Page: 36 36
  2329. bop 0 50 a Fa(162)25 b(TMA-6)228 b(A)51 b(25-50)f(2,4,6-Tri)o(met)o(hox)o(y-)
  2330. o(A)0 110 y(162)25 b(2C-TMA-6)150 b(U)231 b(2,4,6-Tri)o(met)o(hox)o(y-)o(PEA)
  2331. 0 170 y(163)25 b(3-TME)228 b(A)26 b(60-100)49 b(4,5-Dimet)o(hox)o(y-3)o(-e)o
  2332. (thy)o(lth)o(io-)o(PE)o(A)0 230 y(164)25 b(4-TME)228 b(A)26
  2333. b(60-100)49 b(3-Ethoxy-)o(5-m)o(eth)o(ox)o(y-4)o(-me)o(thy)o(lt)o(hio)o(-PE)o
  2334. (A)0 291 y(165)25 b(5-TME)228 b(N)77 b(200)f(3-Ethoxy-)o(4-m)o(eth)o(ox)o
  2335. (y-5)o(-me)o(thy)o(lt)o(hio)o(-PE)o(A)0 351 y(166)25 b(2T-MMDA-3)o(a)99
  2336. b(S)77 b(12)102 b(2-Methylt)o(hio)o(-3,)o(4-)o(met)o(hyl)o(ene)o(di)o(oxy)o
  2337. (-A)0 411 y(167)25 b(4T-MMDA-2)124 b(S)77 b(25)102 b(4,5-Thiom)o(eth)o(yle)o
  2338. (ne)o(xoy)o(-2-)o(met)o(ho)o(xy-)o(A)0 471 y(168)25 b(TMPEA)228
  2339. b(N)77 b(300)f(2,4,5-Tri)o(met)o(hox)o(y-)o(PEA)0 531 y(169)25
  2340. b(2-TOET)202 b(T)77 b(65)102 b(4-Ethyl-5)o(-me)o(tho)o(xy)o(-2-)o(met)o(hyl)o
  2341. (th)o(io-)o(A)0 592 y(170)25 b(5-TOET)202 b(A)51 b(12-25)f(4-Ethyl-2)o(-me)o
  2342. (tho)o(xy)o(-5-)o(met)o(hyl)o(th)o(io-)o(A)0 652 y(170)25 b(2C-5-TOET)124
  2343. b(U)231 b(4-Ethyl-2)o(-me)o(tho)o(xy)o(-5-)o(met)o(hyl)o(th)o(io-)o(PEA)0
  2344. 712 y(171)25 b(2-TOM)228 b(A)26 b(60-100)49 b(5-Methoxy)o(-4-)o(met)o(hy)o
  2345. (l-2)o(-me)o(thy)o(lt)o(hio)o(-A)0 772 y(171)25 b(2C-2-TOM)150
  2346. b(U)231 b(5-Methoxy)o(-4-)o(met)o(hy)o(l-2)o(-me)o(thy)o(lt)o(hio)o(-PE)o(A)0
  2347. 832 y(172)25 b(5-TOM)228 b(A)51 b(30-50)f(2-Methoxy)o(-4-)o(met)o(hy)o(l-5)o
  2348. (-me)o(thy)o(lt)o(hio)o(-A)0 892 y(172)25 b(2C-5-TOM)150 b(U)231
  2349. b(2-Methoxy)o(-4-)o(met)o(hy)o(l-5)o(-me)o(thy)o(lt)o(hio)o(-PE)o(A)0
  2350. 953 y(173)25 b(TOMSO)228 b(A)77 b(150)f(5-Methoxy)o(-4-)o(met)o(hy)o(l-5)o
  2351. (-me)o(thy)o(ls)o(ulf)o(iny)o(l-A)0 1013 y(174)25 b(TP)306
  2352. b(A)51 b(20-25)f(4-Propylt)o(hio)o(-3,)o(5-)o(dim)o(eth)o(oxy)o(-P)o(EA)0
  2353. 1073 y(175)25 b(TRIS)254 b(N)77 b(240)f(3,4,5-Tri)o(eth)o(oxy)o(-P)o(EA)0
  2354. 1133 y(176)25 b(3-TSB)228 b(N)77 b(200)f(3-Ethoxy-)o(5-e)o(thy)o(lt)o(hio)o
  2355. (-4-)o(met)o(ho)o(xy-)o(PEA)0 1193 y(177)25 b(4-TSB)228 b(N)77
  2356. b(240)f(3,5-Dieth)o(oxy)o(-4-)o(me)o(thy)o(lth)o(io-)o(PE)o(A)0
  2357. 1254 y(178)25 b(3-T-TRIS)150 b(S)77 b(160)f(4,5-Dieth)o(oxy)o(-3-)o(et)o(hyl)
  2358. o(thi)o(o-P)o(EA)0 1314 y(179)25 b(4-T-TRIS)150 b(N)77 b(200)f(3,5-Dieth)o
  2359. (oxy)o(-4-)o(et)o(hyl)o(thi)o(o-P)o(EA)951 2825 y Fk(36)p eop
  2360. %%Trailer
  2361. end
  2362. userdict /end-hook known{end-hook}if
  2363. %%EOF
  2364.