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- Document 1000
- DOCN M9651000
- TI Tuberculosis among urban health care workers: a study using restriction
- fragment length polymorphism typing.
- DT 9505
- AU Sepkowitz KA; Friedman CR; Hafner A; Kwok D; Manoach S; Floris M;
- Martinez D; Sathianathan K; Brown E; Berger JJ; et al; Division of
- Infectious Diseases, Cornell University Medical; College, New York, New
- York, USA.
- SO Clin Infect Dis. 1995 Nov;21(5):1098-101. Unique Identifier : AIDSLINE
- MED/96125988
- AB Cases of tuberculosis identified during 1992-1994 through an active
- tuberculosis surveillance network among six hospitals that serve New
- York City (the TBNetwork) were analyzed according to the occupational
- status of the patients. Clinical data were obtained by review of medical
- records, and restriction fragment length polymorphism (RFLP) typing of
- Mycobacterium tuberculosis isolates was performed. No known nosocomial
- outbreaks of tuberculosis occurred at these hospitals in the study
- period. Occupational status was known for 142 of 201 patients whose
- isolates were available for strain typing. Patients infected by
- organisms with a clustered strain typing pattern, as determined by RFLP
- analysis, were presumed to have recently acquired disease. RFLP typing
- revealed that isolates from 13 (65%) of 20 health care workers and 50
- (41%) of 122 non-health care workers had a clustered RFLP pattern. The
- strains infecting eight (89%) of nine health care workers seropositive
- for human immunodeficiency virus (HIV) had a clustered RFLP pattern.
- Multivariate analysis of 75 patients with known HIV and occupational
- status revealed that HIV status (P = .03) and health care worker status
- (P = .02; RR = 2.77) were independent risk factors for a clustered RFLP
- strain. These findings suggest that many of the apparently sporadic
- cases of tuberculosis among health care workers may be due to
- unrecognized occupational transmission.
- DE Adult Bacterial Typing Techniques Cluster Analysis Epidemiology,
- Molecular Female *Health Personnel Human Male Middle Age
- Mycobacterium tuberculosis/CLASSIFICATION/GENETICS/ISOLATION & PURIF
- New York City/EPIDEMIOLOGY Occupational
- Diseases/*EPIDEMIOLOGY/MICROBIOLOGY Polymorphism, Restriction Fragment
- Length Risk Factors Support, Non-U.S. Gov't Tuberculosis,
- Pulmonary/*EPIDEMIOLOGY/MICROBIOLOGY/TRANSMISSION Urban Population
- JOURNAL ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
-
-