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- Document 0998
- DOCN M9650998
- TI Invasive colitis and hepatitis due to previously uncharacterized
- spirochetes in patients with advanced human immunodeficiency virus
- infection.
- DT 9505
- AU Kostman JR; Patel M; Catalano E; Camacho J; Hoffpauir J; DiNubile MJ;
- Department of Medicine, Cooper Hospital/University Medical; Center,
- University of Medicine and Dentistry of New Jersey/Robert; Wood Johnson
- Medical School, Camden, USA.
- SO Clin Infect Dis. 1995 Nov;21(5):1159-65. Unique Identifier : AIDSLINE
- MED/96125997
- AB We describe three patients with advanced human immunodeficiency virus
- (HIV) infection, two with colitis and one with cholestatic hepatitis,
- for whom results of detailed endoscopic and histologic studies were
- suggestive of invasive spirochetosis. In the two patients with colitis,
- colonoscopic evaluation revealed either diffuse ulcerations or pustules;
- in both cases, there was histologic evidence of extensive superficial
- cell necrosis and infiltration of the mucosa and lamina propria with
- acute inflammatory cells. Spirochetes in the mucosa and crypts were
- visualized by Warthin-Starry silver staining. Morphologically similar
- spirochetes throughout the liver specimen from the patient with
- cholestatic hepatitis were demonstrated by Warthin-Starry silver
- staining. Analysis with electron microscopy revealed these organisms to
- be loosely coiled spirochetes. Despite extensive evaluation, no other
- pathogens were identified. Invasive spirochetal infection, as defined by
- the results of Warthin-Starry silver staining of involved tissues,
- should be considered in the differential diagnosis of patients with HIV
- infection who have otherwise unexplained colitis or cholestatic
- hepatitis.
- DE Adult AIDS-Related Opportunistic Infections/*COMPLICATIONS/DIAGNOSIS/
- MICROBIOLOGY Case Report
- Cholestasis/*COMPLICATIONS/DIAGNOSIS/MICROBIOLOGY
- Colitis/*COMPLICATIONS/DIAGNOSIS/MICROBIOLOGY Diagnosis, Differential
- Female Hepatitis/*COMPLICATIONS/DIAGNOSIS/MICROBIOLOGY Human Male
- Microscopy, Electron Spirochaetales/ISOLATION & PURIF/ULTRASTRUCTURE
- Spirochaetales Infections/*COMPLICATIONS/DIAGNOSIS/MICROBIOLOGY JOURNAL
- ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
-
-