home *** CD-ROM | disk | FTP | other *** search
- Document 1068
- DOCN M9621068
- TI Campylobacter infections in HIV-infected patients: clinical and
- bacteriological features.
- DT 9602
- AU Molina J; Casin I; Hausfater P; Giretti E; Welker Y; Decazes J; Garrait
- V; Lagrange P; Modai J; Infectious Disease Department, Saint-Louis
- Hospital, Paris,; France.
- SO AIDS. 1995 Aug;9(8):881-5. Unique Identifier : AIDSLINE MED/96014961
- AB OBJECTIVE: To study the clinical and bacteriological features of
- Campylobacter infections in HIV-infected patients. DESIGN: A
- retrospective analysis (1989-1992), followed by a prospective analysis
- (1992-1994). SETTING: Hospital HIV inpatient unit. PATIENTS AND METHODS:
- All patients with Campylobacter spp. identified by the laboratory of
- microbiology at Saint-Louis Hospital, Paris were studied, and their
- clinical features as well as their response to therapy recorded.
- RESULTS: During the study period, Campylobacter infection was documented
- in 38 HIV-infected patients, 76% of whom had AIDS. Campylobacter spp.
- was isolated from stools in 36 cases and from blood cultures in four
- cases. Species identification yielded C. jejuni (84%) and C. coli (16%).
- High-level resistance to quinolones was frequently observed (21%), but
- resistance to erythromycin (3%) and tetracycline (5%) was rare.
- Diarrhoea, fever and abdominal pain were the main clinical features of
- infection. Other intestinal pathogens were found in 42% of patients.
- Most patients had an acute illness with rapid resolution under
- appropriate antimicrobial therapy. However, eight patients (21%),
- experienced chronic diarrhoea with persistent isolation of Campylobacter
- and in vivo selection of resistant strains, requiring multiple courses
- of antibiotics. CONCLUSIONS: Campylobacter usually cause acute diarrhoea
- in patients with HIV infection. Antimicrobial therapy should be guided
- on in vitro susceptibility testing because of the prevalence of
- antibiotic resistance. Despite appropriate therapy, some patients will
- present with prolonged diarrhoea and in vivo selection of multiresistant
- isolates.
- DE Adult Antibiotics/THERAPEUTIC USE AIDS-Related Opportunistic
- Infections/*DIAGNOSIS/DRUG THERAPY/ MICROBIOLOGY *Campylobacter
- coli/DRUG EFFECTS/ISOLATION & PURIF *Campylobacter jejuni/DRUG
- EFFECTS/ISOLATION & PURIF Case Report Diarrhea/COMPLICATIONS/DRUG
- THERAPY/MICROBIOLOGY Drug Resistance, Microbial Feces/VIROLOGY Female
- Human Male Middle Age Prospective Studies Retrospective Studies
- Support, Non-U.S. Gov't JOURNAL ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
-
-