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- Document 0503
- DOCN M9620503
- TI Prolonged shedding of amantadine-resistant influenzae A viruses by
- immunodeficient patients: detection by polymerase chain
- reaction-restriction analysis.
- DT 9602
- AU Klimov AI; Rocha E; Hayden FG; Shult PA; Roumillat LF; Cox NJ; Influenza
- Branch, Centers for Disease Control and Prevention,; Atlanta, Georgia
- 30333, USA.
- SO J Infect Dis. 1995 Nov;172(5):1352-5. Unique Identifier : AIDSLINE
- MED/96036396
- AB Consecutive A (H3N2) influenza virus isolates from 2 influenza
- virus-infected immunodeficient patients treated with amantadine were
- examined using a novel polymerase chain reaction (PCR)-restriction
- analysis for resistance to this antiviral compound. The data indicate
- that immunodeficient patients may shed resistant viruses for prolonged
- periods and with different drug resistance mutations present at
- different times. This PCR-restriction technique allows rapid detection
- of amantadine- or rimantadine-resistant strains.
- DE Adult Amantadine/*PHARMACOLOGY Antiviral Agents/*PHARMACOLOGY Base
- Sequence Bone Marrow Transplantation/*IMMUNOLOGY Case Report Drug
- Resistance, Microbial DNA Primers Female Human Immunosuppression
- Infant, Newborn Influenza/*ETIOLOGY/VIROLOGY Leukemia, Myelocytic,
- Acute/THERAPY Male Molecular Sequence Data Orthomyxovirus Type A,
- Human/DRUG EFFECTS/GENETICS/*ISOLATION & PURIF Polymerase Chain
- Reaction/*METHODS Severe Combined
- Immunodeficiency/*COMPLICATIONS/THERAPY *Virus Shedding JOURNAL
- ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
-
-