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- Document 0216
- DOCN M9620216
- TI Brain lesions in patients with AIDS: H-1 MR spectroscopy.
- DT 9602
- AU Chang L; Miller BL; McBride D; Cornford M; Oropilla G; Buchthal S;
- Chiang F; Aronow H; Ernst T; Department of Neurology, Harbor-University
- of California Los; Angeles Medical Center, University of California Los
- Angeles; School of Medicine, Torrance 90509, USA.
- SO Radiology. 1995 Nov;197(2):525-31. Unique Identifier : AIDSLINE
- MED/96027971
- AB PURPOSE: To evaluate the role of proton (hydrogen-1) magnetic resonance
- (MR) spectroscopy in the differential diagnosis of focal brain lesions
- in patients with acquired immunodeficiency syndrome (AIDS). MATERIALS
- AND METHODS: Twenty-six men with 35 AIDS-related brain lesions underwent
- MR imaging and localized H-1 MR spectroscopy. Lesions consisted of 11
- toxoplasmic abscesses, 12 progressive multifocal leukoencephalopathic
- lesions, eight lymphomas, and four cryptococcomas. Metabolite peak areas
- in the lesions were compared with those in the contralateral hemisphere
- in each patient. RESULTS: H-1 MR spectroscopic findings showed
- significantly different biochemical profiles for each diagnostic group
- (P = .0001) with regard to N-acetyl compounds, total creatine pool,
- choline-containing compounds, myoinositol, and lactate. H-1 MR
- spectroscopy alone helped correctly diagnose 94% (84% with jackknifed
- classification) of the brain lesions, without overlap between
- toxoplasmosis and lymphoma. CONCLUSION: H-1 MR spectroscopy is a
- sensitive and potentially specific noninvasive adjunctive method for
- differential diagnosis of focal brain lesions in AIDS.
- DE Abscess/DIAGNOSIS/METABOLISM/PARASITOLOGY Adult Aspartic Acid/ANALOGS
- & DERIVATIVES/METABOLISM AIDS Dementia
- Complex/*DIAGNOSIS/METABOLISM/MICROBIOLOGY/ PARASITOLOGY Brain
- Diseases/*DIAGNOSIS/METABOLISM/MICROBIOLOGY Brain
- Neoplasms/DIAGNOSIS/METABOLISM Choline/METABOLISM Comparative Study
- Creatine/METABOLISM Cryptococcosis/DIAGNOSIS/METABOLISM Diagnosis,
- Differential Human Hydrogen Inositol/METABOLISM Lactates/METABOLISM
- Leukoencephalopathy, Progressive Multifocal/DIAGNOSIS/METABOLISM
- Lymphoma, AIDS-Related/DIAGNOSIS/METABOLISM Magnetic Resonance Imaging
- Male Middle Age Nuclear Magnetic Resonance/*DIAGNOSTIC USE
- Sensitivity and Specificity Support, U.S. Gov't, P.H.S. Toxoplasmosis,
- Cerebral/DIAGNOSIS/METABOLISM JOURNAL ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
-
-