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- Document 0034
- DOCN M9620034
- TI Implications of human T-lymphotropic virus type-I and type-II testing in
- donors and patients.
- DT 9602
- AU Fischer HE; Lichtiger B; Glassman AB; Division of Laboratory Medicine,
- University of Texas M. D.; Anderson Cancer Center, Houston 77030, USA.
- SO Ann Clin Lab Sci. 1995 Sep-Oct;25(5):373-80. Unique Identifier :
- AIDSLINE MED/96042726
- AB The retroviruses known as Human T-Lymphotropic Virus Types I and II
- (HTLV-I and -II) were recognized before the human immunodeficiency virus
- (HIV-1). Associated diseases of HTLV-I infection, including a particular
- kind of leukemia or the development of a specific demyelinating disease,
- have also been observed. Screening of blood donors for antibodies to
- HTLV was mandated in November of 1988. This paper examines the biology
- of HTLV-I and HTLV-II and reviews the testing methods for HTLV-I/II.
- Data from 39,908 blood donations of volunteer donors at The University
- of Texas M. D. Anderson Cancer Center (UTMDACC), Division of Laboratory
- Medicine, Section of Transfusion Medicine are presented. Initially
- reactive specimens for HTLV antibodies were 158 (0.4 percent). Of these
- 0.26 percent or 105 of 39,908 were repeatedly reactive. Eight hundred
- and sixty-seven cancer patients were also tested for HTLV antibodies.
- Eight or 0.9 percent were repeatedly reactive for HTLV antibodies by
- enzyme immunoassays (EIA), but only one could be confirmed as positive.
- HTLV-I/II has a very low incidence in the ambulatory population. The
- relationship of clinical sequelae and the rate of transmission of these
- viruses remain unclear. A readily applicable confirmatory test is not
- yet available. Even significant improvements in the sensitivity and
- specificity of testing will present ongoing problems for identification
- of true HTLV carriers. The clinical decision-making process related to
- the meaning of these results continues to be difficult.
- DE Adult Aged *Blood Donors Female Human HTLV-I Antibodies/*BLOOD
- HTLV-II Antibodies/*BLOOD Male Middle Age Neoplasms/VIROLOGY
- Support, Non-U.S. Gov't JOURNAL ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
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-