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- THE WEEK, Page 21HEALTH & SCIENCEEt Cetera
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- BRITTLE BONES
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- Postmenopausal women often get osteoporosis, a weakening of
- the bones that can lead to easy fracture. A report in Science
- may explain why. A drop-off in the hormone estrogen leads to an
- overproduction of osteoclasts, cells whose job is to scour away
- aging bone cells. Trouble is, other cells called osteoblasts,
- which fill in the holes left by osteo clasts, don't increase
- proportionately. If humans respond the same way as lab mice, new
- drugs could supersede current estrogen-replacement therapy,
- which can cause fluid retention and leg cramps.
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