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- <text id=93TT1048>
- <title>
- Mar. 01, 1993: AIDS Triple Play
- </title>
- <history>
- TIME--The Weekly Newsmagazine--1993
- Mar. 01, 1993 You Say You Want a Revolution...
- </history>
- <article>
- <source>Time Magazine</source>
- <hdr>
- THE WEEK, Page 16
- HEALTH & SCIENCE
- AIDS Triple Play
- </hdr>
- <body>
- <p>Researchers hit on a new chemical combination to combat the virus
- </p>
-
- <p> It is not a cure. It is not even a treatment yet. But preliminary
- research, revealed in Nature, points to a new way to attack
- the AIDS virus. By targeting a single phase in the virus' life
- cycle with three drugs, Yung-Kang Chow and his colleagues at
- Massachusetts General Hospital found that they could stop the
- infection cold--in the test tube anyway.
- </p>
- <p> Operating alone, each of the three drugs--AZT, ddI and pyridinone--merely slows down the virus' ability to reproduce. Eventually,
- the microbe mutates and becomes resistant to treatment. Chow's
- triple combo, however, appears to overwhelm HIV's ability to
- develop into new strains. More than a month after the scientists
- stopped treatment of their laboratory cultures, they could find
- no virus.
- </p>
- <p> This spring researchers will try out the combination therapy
- on 200 volunteer patients. Chow's approach could still wind
- up on the dustheap of medical history; numerous treatments that
- looked promising in the laboratory failed miserably in the clinic.
- Even if it works, the triple-dose treatment cannot eradicate
- virus particles that have already tunneled their way into human
- chromosomes. However, Chow's approach might transform AIDS into
- a more manageable chronic condition.
- </p>
-
- </body>
- </article>
- </text>
-
-