ocr: Polymorphic Associated Gene Examples of Substrate Site Known Cancer Comments METABOLIC ACTIVATION CYP2D6 Debrisoquine, Yes (mostly) Lung Phenotyping method available; over 13 polymor- dextromethorphan phisms have been identified, and families have been: shown to inheritmultiple.copes,wideracial variation exists. CYPIAI Polycyclic aromatic Yes Lung Dilterent polymorphisms exist in different racial hydrocarbons populations; several studies relate a functionally active polymorphism to lung cancer in Japanese; wide racial variation and crossover occurred in some races. CYP2EI N-nitrosamines, benze ...
