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- FIGURE 9-2. Schematic presentation of functional stages in
- experimental carcinogenesis synthesized from several model systems.
- Stages are defined by specific biologic and biochemical alterations
- and linked to genetic changes. The horizontal axis is an approximate
- time line. The thickness of horizontal lines correlates with the
- approximate frequency of progression from one stage to another. This
- serves as a hypothetical framework for additional biochemical studies
- in the context of stage-specific consequences of a particular
- metabolic alteration.
-