ocr: WHOLE TUMOR CELL VACCINES MODIFIED IN VIVO OR EX VIVO Admixture with adjuvant (chemical, bacterial, or viral) Physical alteration (yirradiation) Gene modification (with IL-2, INF-a, IFN-y, GM-CSF, B7) TUMOR-DERIVED HEAT SHOCK PROTEINS RECOMBINANT AND SYNTHETIC VACCINES Peptides and proteins (pulsed onto dendritic cells or given with adju- vants) Plasmid DNA (intramuscular injection, gene gun") Recombinant viruses (fowlpox, vaccinia, adenovirus) Recombinant organisms (BCG, Listeria, salmonella)
