ocr: Strategies Examples of Potential Expermental Approaches GENETIC MODIFICATION OF THE IMMUNE RESPONSE Active immunization Modification of tumor cells with genes that Patient mmunization with tumor cells modified by the introduction of cytokine genes enhance tumor mmunogenicaty (eg.IL-2orGM-CSE): or costimulatory molecules (e.g., B7-1); gene transferi into cumor cells can be performed in the laboratory (ex vivo) or directly in the patient (in vivo) Immunization with genes encoding cumor Patient immunization with genes encoding melanoma antigens recognized by T cells, antigens such as MARI-1; ammu ...
