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   ocr: Tumor Direct gonadal involvement Reproductive tract involvement Hypothalamic and pituitary involvement Concern about heritability of cancer susceptibility Surgery Removal of gonad Genital mutilation Failure of emission and retrograde ejaculation Impotence and loss of orgasm Radiotherapy or Germ cell depletion chemotherapy Loss of gonadal hormones Mutagenic changes in germ cells Teratogenic effects on fetus Chemotherapy Seminal transmission of drug Radiotherapy Loss of gonadotropic hormones (cranial)