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- FIGURE 5-3. (A) Map of the BCR-ABL fusion gene in CML and in some
- adult ALL patients. In this example, the breakpoint has occurred
- between the third and fourth exons included in the bcr region, which
- are equivalent to exons 11 and 12 in the BCR gene. The chimeric mRNA
- is diagrammed below the gene. (B) Map of the fusion gene in some ALL
- patients showing the breakpoint in the first intron of BCR. The
- breakpoint in ABL is identical with that in CML in this example. Only
- one BCR exon is included so that the mRNA is much smaller than in CML.
-