ocr: Cell Type Nodular Lymphocyte Predominance Classic Tumor cells Lymphocytic and histiocytic or popcorn cells Diagnostic Reed-Sternberg cells; mononuclear or lacunar cells Diagnostic Reed- Usually absent Present Sternberg cells Pattern Nodular, at least in part Nodular, diffuse, or interfollicular CD15 Negative Usually positive CD30 Negative Usually positive CD20 Positive Usually negative CD45 Positive Usually negative Epstein-Barr virus Negative Often positive (40%-70%)