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   ocr: Complication Causes and Risk Factors Management and Prevention Immunologic dyslunction Underlying disease, therapy Appropriate vaccinations Herpes zoster or varicella Underlying disease, therapy Systemic antiviral therapy, zoster immune globulin Pneumococcal sepsis Splenectomy, functional Pretherapy pneumonococcal vaccinc, selected asplenia after RT antibiotic prophylaxis, avoid unnecessary staging splenectomy Nonlymphocytic leukemia Therapy, older than 40 y Avoid combined-modality therapy for Hodgkin's disease. Supportive care, low-dose chemotherapy, aggressive therapy with or without bone ma ...