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   ocr: Transcription and cell cycle control E1A Rb MYC E2F g Irradiation Developmental p53 Mdm2 cues p21, - GADD45 CDK, PCNA Fasl./TNF Bcl-2 family inhibition Mcl-1 Bcl-21--Bax Bak Nbk FAS/TNFR1 E1B 19K Bcl-KL--Bcl-xs Bad Growth arrest ? Survival factors ICE-like cysteine proteases ICE Mch-2 TX/ICErer'lich-2 ICErer-lll ch-1/NEDD2 CPP32 CrmA I p35 1 / - * - * IL1-b lamins and other substrates PARP I / . Inflammation Apoptosis