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- FIGURE 38.3-12. The T-10 regimen from Memorial Sloan-Kettering Cancer
- Center. (A) All patients receive the initial 16-week regimen. The
- presurgical chemotherapy regimen features four weekly courses of
- high-dose methotrexate and leucovorin rescue followed by resection of
- amputation. Patients undergoing endoprosthetic replacement receive 16
- weeks of presurgical chemotherapy. (B) Postoperative chemotherapy is
- determined by the histologic grade of response of the primary tumor to
- presurgical chemotherapy. Patients who achieve an unfavorable response
- in the primary tumor (grades I and II) receive T-10A regimen
- postoperatively, featuring doxorubicin, cisplatin, and the BCD
- combination. Patients achieving a favorable response (grades III and
- IV) receive the T-10B regimen postoperatively and continue to receive
- high-dose methotrexate with doxorubicin and the BCD combination.
- (Rosen G, et al. Primary osteogenic sarcoma: eight-year experience
- with adjuvant chemotherapy. J Cancer Res Clin Oncol
- 1983;106[Suppl]:55)
-