home *** CD-ROM | disk | FTP | other *** search
- FIGURE 37.1-3. Flow diagram of proven and postulated events in thyroid
- follicular cell tumorigenesis. Mutations in the RAS oncogene are
- believed to be early events in the genesis of follicular neoplasms.
- Activation of the RET and TRK receptor tyrosine kinases is specific to
- papillary thyroid carcinomas. The association of mutations in the p53
- tumor suppressor gene with undifferentiated thyroid tumors suggests
- that mutations in TP53 are a critical event in the progression of
- follicular carcinoma to anaplastic carcinoma.
-