ocr: Veoadyuvant Adjuvant RATIONALE Early treatment of micrometastases Inverse relationship of tumor burden and cure + + Increased chemosensitivity of small-volume, high-growth fraction tumors + + Decreased chance of spontancous resistance + FACTORS FAVORING NEOADJUVANT THERAPY Chemosensitivity determined case by case in vivo: endpoints more precise Downstaging" of the primary tumor Decreases the extent and need for additional therapy Converts an "unresectable" to a 'resectable" lesion Drug dielivery not compromised by previous surgery or radiotherapy Response may guide treatment advised for the pr ...
