ocr: DOMINANT ONCOGENES Point mutation (RAS) Gene amplification (MYC family, HER2/neu, also called ERBB2) Deregulated overexpression by unknown mechanism (BCL2, MYC, HER2/neu, KIT) RECESSIVE ONCOGENES (ASSOCIATED LOSS OF WILD-TYPE ALLELE) Point mutations resulting in single amino acid substitutions (p53) Point mutations and few base-pair deletions or insertions resulting in stop codons and protem truncation p53,RB) Splicing errors resulting in a variety of amino acid sequence changes (p33, RB, FHIT) Intragenic deletions (RB, p16) Larger deletions (RB, p16, FHIT, and other 3p recessive oncogenes) Hy ...
