ocr: p53 pathway Normal p53 Mutant p53 pathway pathway T - Increased p53 DNA Damage No functional p53 - - - aa - - - - G1a arrest for DNArepair No G1 arrest; continued cell cycling - Apoptosis if DNA - - not repairable IDNA 00 repaired . 00 00 Cell cycle continues DNA not repaired: genetic damage maintained through successive cell generations
