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- FIGURE 2-2. MAP kinase pathways. At least three MAP kinase signal
- transduction modules have been identified in mammalian cells. These
- modules each result in the activation of different MAP kinase
- homologues, ERKs, SAP kinase, and p38. The MAP kinases are activated
- by dual specificity MAP kinase kinases (MEKs and MKKs), which are in
- turn phosphorylated and activated by MAP kinase kinase kinases (Rafs
- and MEKKs).
-