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Text File  |  1999-06-07  |  779 b   |  12 lines
  1. FIGURE 19.6-1. Mechanism of action of methotrexate. Sites of action of
  2. MTX,  its  polyglutamated  antimetabolites  [MTX(Glu(n))], and  folate
  3. byproducts  of the  inhibition of  dihydrofolate  reductase, including
  4. dihydrofolate (FH(2)) and  10-formyldihydrofolate (10-CHO-FH(2)). Also
  5. shown   are  5-10-methylenetetrahydrofolic   acid  (CH(2)-FH(4))   and
  6. 10-formyl-tetrahydrofolate (10-CHO-FH(4)),  which are required  for de
  7. novo  thymidylate and  purine  synthesis,  respectively. IMP,  inosine
  8. monophosphate;   AMP,   adenosine    monophosphate;   GMP,   guanosine
  9. monophosphate,  dUMP,  deoxyuridine   monophosphate;  dTMP,  thymidine
  10. monophosphate; GAR, glycinamide  ribonucleotide transformylase; AICAR,
  11. aminoimidazole carboxamide ribonucleotide transformylase.
  12.