ocr: 500 400 GM-CSF 300 - (pg/ml) 200 100 - 0 100 Stimulator 80 None Autol Breast TU TNF-a 60 - l L Allo Autol 8 Breast Cell TU1 (pg/ml) 40 - Allo Allo Breast Breast TU: TU: 3 2 Allo Breast TU4 20 0 50 40 - IFN-y 30 (U/ml) 20 - 10 1 2 3 Days in Culture FIGURE 18-2. Demonstration of unique tumor antigens on breast cancer as evidenced by specific cytokine secretion by TIL. TIL from a patient with breast cancer secreted granulocgte-macrophage colony- stimulating factor. INF-a, andinterferon-yonly when cocultured with the autologous breast cancer (0) and not with an autologous B-cell line (A) or with f ...
