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- FIGURE 14-1. Carcinogenesis is a multistep process. The transition
- from completely normal to frankly malignant occurs through a series of
- mutations in genes that control cell growth and differentiation.
- Epigenetic phenomena, such as methylation, also play a role. Early
- "hits" may have little apparent phenotypic effect, but ultimately
- growth patterns and cellular morphology are altered.
-