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   ocr: Disease Marker* Means of Detection Principal Applications FAMILIAL CANCERS Breast BRGAI, BRCA2 mutation Colonic APC, MSH2, MLH1, PMSI, PMS2 mutation Retinoblastoma, various RB mutation PCR/SSCP Diagnosis of hereditary sarcomas WTT mutation PCR/BRC predisposition Wilms tumor TP53 mutation PCR/DGGE Li-Fraumeni syndrome RET mutation PCK/sequence analysis MEN la and 2 VHL mutation Kidney cancer NFI, NF2 mutation Neurofibrosarcoma