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- FIGURE 11-1. Estradiol and to a lesser degree other steroid hormones
- (e.g., progesterone) drive breast cell proliferation which facilitates
- mutation or enhances fixation of mutations or facilitates expression
- of genetic errors by loss of heterozygosity by defects in DNA repair.
- Germline mutations in relevant tumor-suppressor genes accelerate the
- transformation to the malignant phenotype.
-