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answer2
PTHrP
Parathyroid Hormone Releasing Peptide, (PTHrP), is correct. This is a hormone which
mimics the effects of PTH on bone and kidney and is the commonest
reason for hypercalcaemia in malignancy.
answer2
answer2
pthrp
BoneMetastases
EctopicPTH
OtherFactor
answer2
Parathyroid
answer2
Hormone
answer2
related
answer2
peptide
Parathyroid Hormone Releasing Peptide, (PTHrP), is correct. This is a hormone which
mimics the effects of PTH on bone and kidney and is the commonest
reason for hypercalcaemia in malignancy.
answer2
answer2
pthrp
BoneMetastases
EctopicPTH
OtherFactor
answer2
Parathyroid
answer2
Hormone
answer2
releasing
answer2
peptide
Parathyroid Hormone Releasing Peptide, (PTHrP), is correct. This is a hormone which
mimics the effects of PTH on bone and kidney and is the commonest
reason for hypercalcaemia in malignancy.
answer2
answer2
pthrp
BoneMetastases
EctopicPTH
OtherFactor
Wrong. Parathyroid Hormone Releasing Peptide, (PTHrP), is correct. This is a hormone which
mimics the effects of PTH on bone and kidney and is the commonest
reason for hypercalcaemia in malignancy.
answer2
pthrp
BoneMetastases
EctopicPTH
OtherFactor
Hyperparathyroidism Test
Cause of Back Pain
Likely Diagnosis after Testing
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Medi-CAL
nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnng Unit
University of Aberdeenberdeen
University of Aberdeen
Hypercalcaemia IIeee
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Introduction
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To refer or not to refer
Outcome after Treatment
Summary after Treatment
-- Case Study Series
HDr Neil M Hamilton
'Two V2.0a
-- Copyright University
Aberdeen
-- 07/06/93
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Case Study Two. Developed by the Medical Faculty CAL Unit, University
of Aberdeen. Medical Content by Stuart Ralston, MD, FRCP. Design by Neil M Hamilton, BSc, PhD.
ReadTheNotes
A seventy two year old woman was sent up to the clinic
with back pain and chest pains. Her GP discovered that she was
hypertensive (180/100) some five years previously and has
treated her with bendrofluazide 2.5mg/day. The referral letter
contains details of blood tests performed by the GP.
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Medi-CAL
nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnng Unit
University of Aberdeenberdeen
University of Aberdeen
Hypercalcaemia IIeee
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Medi-CAL
nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnng Unit
University of Aberdeenberdeen
University of Aberdeenn
explain
Hypercalcaemia Ieeee
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"Exit the
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"Remember - You should have a hand-out"&&\
"on hypercalcaemia which details reference material."&&\
"Read those references
more information."&&\
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f"Yes"
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Remember - You should have a hand-out
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Summary after Treatment
Browse Backwards.
University of Aberdeen, 1993
Portions of this application are the copyright of Asymetrix Corporationnn""""
txclassname
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Main Points
This is a typical case of PHPT. The disease is commonest in post-menopausal women and this group seem to run an increased risk of osteoporosis and the presence of osteoporosis is a positive indication for surgical treatment. Bone density generally increases (often quite substantially) after successful surgery. The reversal of hypertension after PTX is also well documented.
Go to the first page.
To refer or not to refer
EnterPage
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"two"
"three"
"four"
"five"
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Browse Forwards.
Nothing
No - some sort of follow up would be indicated.
MonitorCalcium
Yes - check weekly. Also, think
about giving prophylaxis.
GiveProphylaxis
A good suggestion, although life expectancy of these patients is short and not all will need prophylaxis. Monitoring calcium is also recommended.
TestOptionText
The diagnosis looks like PHPT. Osteoporosis is a well recognised complication of PHPT in postmenopausal women (see reference 16 in main document). What would you do now?
Give bisphosphonates
Observe
"one"
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"five"
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Parathyroid scan de levels to see if they are raised
Refer for parathyroidectomy
Limit dietary calcium intake
Parathyroid scan: No, localising investigations are not indicated in PHPT, except in the very rare cases where a neck exploration has failed to uncover a PT adenoma. Parathyroids can occasionally be 'ectopic' and lie in the mediastinum.............................
three
Observe: No. She has complications (osteoporosis and hypertension) which may respond to parathyroidectomy........
Limit dietary calcium intake: No. This actually would make her osteoporosis worse and would make little impact on the hypercalcaemia..............................ractures.
Bisphosphonates: No. These can be helpful in patients with severe hypercalcaemia in the pre-operative phase. They do not work well in mild PHPT since the hypercalcaemia is often largely due to increased renal tubular calcium reabsorption.
Parathyroidectomy: Yes. The treatment of choice for PHPT.
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Treatment
The Patient Presents
LastPage
Relevant Drug Intake
Medi-CAL
nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnng Unit
University of Aberdeenberdeen
University of Aberdeenn
Hypercalcaemia IIeee
txclassname
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Main Points
MainPoints
Hypercalcaemia is a common problem both in hospital medicine and in general practice. It is not a disease in itself, but metabolic complication of disease. Many underlying diseases can be complicated by hypercalcaemia and because of this most doctors will encounter hypercalcaemic as a diagnostic and theraputic problem.
MAIN POINTS
(1) Hypercalcaemia is not a disease in itself but a metabolic complication of one of many underlying disease processes.
(2) Hypercalcaemia is due to failure of the normal homeostatic mechanisms responsible for regulation of plasma calcium. These involve the calciotropic hormones PTH and 1,25 DHCC and their sites of action in bone intestine and kidney.
(3) Mild hypercalcaemia may be asymptomatic but symptoms become progressively more common as hypercalcaemia worsens.
(4) The symptoms of hypercalcaemia are non-specific and often overlooked or mistaken for those of other diseases.
(5) Severe hypercalcaemia is a MEDICAL EMERGENCY; it can cause irreversible organ damage and may be fatal!
(6) The two most common causes of hypercalcaemia are cancer and primary hyperparathyroidism.
(7) The best method of treating hypercalcaemia is to define and treat the underlying cause.
(8) Medical antihypercalcaemia therapy may be required where the primary cause cannot be treated (usually in cancer patients)
(9) Medical antihypercalcaemic therapy consists of intravenous saline (to increase urinary calcium excretion) and bisphosphonates (to inhibit bone resorption) bone resorption)))))))))))))))))ause cannot be treated (usually in cancer patients)
(9) Medical antihypercalcaemic therapy consists of intravenous saline (to increase urinary calcium excretion) and bisphosphonates (to inhibit bone resorption)))))))))))))))))))))common problem both in hospital medicine and in general practice. It is
not a
disease in itself, but metabolic complication of disease. Many underlying diseases can be
complicated by hypercalcaemia and because of this most doctors will encounter
hypercalcaemic as a
diagnostic and theraputic problem. This programme gives details on the normal control of
calcium
homeostasis, differential diagnosis and management of hypercalcaemia.
ESTIMATED STUDY TIME
1-2 Hours
HOW TO USE THIS MATERIAL
You can complete this program in two ways:
(1) By working through the document on computer (Mac and PC versions available)
(2) By working through the written document.
Whatevere you choose, test your knowledge at the end by working through the
hypercalcaemia quiz
(on disk, available from library issue desk).
LEARNING POINTS
(1) Hypercalcaemia is not a disease in itself but a metabolic complication of one of many
underlying
disease processes.
(2) Hypercalcaemia is due to failure of the normal homeostatic mechanisms responsible for
regulation
of plasma calcium. These involve the calciotropic hormones PTH and 1,25 DHCC and their
sites of
action in bone intestine and kidney.
(3) Mild hypercalcaemia may be asymptomatic but symptoms become progressively more
common as
hypercalcaemia worsens.
(4) The symptoms of hypercalcaemia are non-specific and often overlooked or mistaken for
those of
other diseases.
(4) Severe hypercalcaemia is a MEDICAL EMERGENCY; it can cause irreversible organ
damage and
may be fatal!
(5) The two most common causes of hypercalcaemia are cancer and primary
hyperparathyroidism.
(6) The best method of treating hypercalcaemia is to define and treat the underlying cause.
(8) Medical antihypercalcaemia therapy may be required where the primary cause cannot be
treated
(usually in cancer patients)
(9) Medical antihypercalcaemic therapy consists of intravenous saline (to increase urinary
calcium
excretion) and bisphosphonates (to inhibit bone resorption).
underlying cause.
(8) Medical antihypercalcaemia therapy may be required where the primary cause cannot be
treated
(usually in cancer patients)
(9) Medical antihypercalcaemic therapy consists of intravenous saline (to increase urinary
calcium
excretion) and bisphosphonates (to inhibit bone resorption).
tes (to inhibit bone resorption).
nhibit bone resorption).
apy consists of intravenous saline (to increase urinary
calcium
excretion) and bisphosphonates (to inhibit bone resorption).
txclassname
3DFrame
HYPERCALCAEMIA SELF LEARNING MODULE
This text is taken directly from the handout
ASSESSMENT AND MANAGEMENT OF HYPERCALCAEMIAA ASSESSMENT AND MANAGEMENT OF HYPERCALCAEMIAAAAAAAAA MANAGEMENT OF HYPERCALCAEMIA
Browse Backwards.
3DFrame Recessed
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Summary after Treatment
Browse Backwards.
University of Aberdeen, 1993
Portions of this application are the copyright of Asymetrix Corporationnn""""
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Main Points
This is a typical case of PHPT. The disease is commonest in post-menopausal women and this group seem to run an increased risk of osteoporosis and the presence of osteoporosis is a positive indication for surgical treatment. Bone density generally increases (often quite substantially) after successful surgery. The reversal of hypertension after PTX is also well documented.
EnterPage
"explain"
default
LeavePage
EnterPage
LeavePage
EnterPage
explain
default
LeavePage
Outcome after Treatment
The patient undergoes parathyroidectomy and a single adenoma is removed from the R inferior position. One year later she is feeling well. There have been no more episodes of back pain and spinal bone density measurements have shown an increase of 15%!!
Her BP is now normal without therapy.
Well done ! Please move on one page for a summary....
answerbox1
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txclassname
Main Points
Possible Thiazide Involvement
First Moves
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Browse Forwards.
TestOptionText
What would you do now ? to perform? Choose only relevant tests.. Look at the values and decide whether they are normal or abnormal. The next page will reitterate these results so don't worry about copying them down...
Take a detailed drug history
Order a whole body MRI scan with contrast enhancementttt
Tell her that her doctor was worrying about nothing and she has probably just pulled
a muscle in her back
"one"
"two"
"three"
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Pulled Muscle: Find a good lawyer - you'll need one for the GMC hearing and the litigation.
Drug History: Yes. You would of course do this anyway but it is especially important in hypercalcaemia.
three
Whole Body MRI Scan: There's no such thing.
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Calcium Antagonists
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Considering Diagnoses
Outcome after Treatment
The patient undergoes parathyroidectomy and a single adenoma is removed from the R inferior position. One year later she is feeling well. There have been no more episodes of back pain and spinal bone density measurements have shown an increase of 15%!!
Her BP is now normal without therapy.
Well done ! Please move on one page for a summary....
answerbox1
txclassname
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Browse Forwards.
The Patient Presents
Browse Backwards.
EnterPage
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EnterPage
EnterPage
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A seventy two year old woman is sent up to the clinic with back pain and chest pains. Her GP discovered that she was hypertensive (180/100) some five years previously and has treated her with bendrofluazide 2.5mg/day. The referral letter contains details of blood tests performed by the GP. Your aim is to identify the correct treatment.
txclassname
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--This handler tests
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"help"
B"TheTumor"
B"Hyperparathyroidism"
B"Theconfusion"
B"Theanaemia"
PTH),
"Sorry.
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Type your answer in the yellow box. Do not use numbers,
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answer1
Yes. Parathyroid Hormone, (PTH), is correct. The PTH would be raised.
answer1
answer1
TheTumor
Hyperparathyroidism
Theconfusion
Theanaemia
answer1
Parathyroid Hormone
Yes. Parathyroid Hormone, (PTH), is correct. The PTH would be raised.
answer1
answer1
TheTumor
Hyperparathyroidism
Theconfusion
Theanaemia
Sorry. Parathyroid Hormone, (PTH), is correct. The PTH would be raised.
answer1
TheTumor
Hyperparathyroidism
Theconfusion
Theanaemia
Thiazide Experiment Results
System
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se Study One
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Case Study Two
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First Moves
Introduction
Introduction
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Click the browse button marked & to starttrt
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University of Aberdeen, 1993
Portions of this application are the copyright of Asymetrix Corporationnn""""
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Click the Help button marked ? or choose Help from the menubar at the top of the page if you are stuck. Glossary of Complications.
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Hyperparathyroidism Test
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You have now eliminated thiazide induced hypercalcaemia as a diagnosis. That leaves you with hyperparathyroidism as a possibility.
If you could do a single test to make the diagnosis, what would it be?
answer1
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Medi-CAL
nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnng Unit
University of Aberdeenberdeen
University of Aberdeenn
Hypercalcaemia IIeee
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The Patient Presents
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A seventy two year old woman is sent up to the clinic with back pain and chest pains. Her GP discovered that she was hypertensive (180/100) some five years previously and has treated her with bendrofluazide 2.5mg/day. The referral letter contains details of blood tests performed by the GP. Your aim is to identify the correct treatment.
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Cause of Back Pain
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Frusemide
Frusemide: No.This would just make him dehydrated and make things worse. Try some of the other options.ions.
Fluids
Fluids: Yes. Intravenous fluids will help calcium excretion. Use saline not dextrose though, since a sodium diuresis promotes a calcium diuresis by reducing calcium reabsorption in the proximal renal tubule. Try some of the other options.ions..
Mithramycin
Mithramycin: No. Mithramycin is too toxic and has been superseded. Try some of the other options..ons.
Calcitonin
Calcitonin: Possibly. This is an effective hypercalcaemic drug, however the reaction of calcitonin is relatively short. Calcitonin is useful for the rapid control of more severe hypercalcaemia since it works quickly. Try some of the other options........e above options.
Bisphosphonate
Bisphosphonate: Yes. Bisphosphonates are potent inhibitors of bone resorption and with their long duration of action are the treatment of choice ! Try some of the other options..ons.ht be worth considering ?
TestOptionText
Of course doctors (especially the physicians) never just do one test !! In this patient we also want to find out the cause of the back pain. How would you investigate this?
Bone scan
CT Scan abdomen
X-ray spine iazide levels to see if they are raised
Barium enema
Bone density
Xray spine: Good. The X-ray shows osteopaenia with several collapsed vertebrae. litigation.
three
CT Scan: No, the clinical history suggests musculo-skeletal pain and other investigations take precedence.
Bone density: Not a bad idea, but it would not tell you about the origin of the pain. Osteopaenia (i.e. low bone density) does not cause pain in the absence of fractures.
Bone scan: I would do x-ray first. Bone scan is better if you suspect metastases but here we do not....................................
Barium enema: ??**!!???
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Browse Forwards.
Relevant Drug Intake
Browse Forwards.y
HypercalcText
Which of the following drug intakes are relevant to hypercalcaemia ?
Hint - there are 4 correct choices !?????
"Yes, but very rare. One reported
Mwas a"&&\
"Californian vegan who lived only on carrot juice."&&\
"Remember retinoic acid derivatives
acne!"
buttonup
buttonup
120,50,100
Yes, but very rare. One reported case was a
Californian vegan who lived only on carrot juice.
Remember retinoic acid derivatives in acne!
Vitamin A
"No."
buttonup
buttonup
0,50,100
Vitamin K
"Yes. This
obvious cause
hypercalcaemia."
buttonup
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120,50,100
Yes. This is an obvious cause of hypercalcaemia.
Vitamin D
Three
"Yes - especially Rennies
the like, which"&&\
"are 'over
counter' treatments
often forgotten about."&&\
"These can cause
b'milk-alkali' syndrome,
r should"&&\
"probably be renamed
'calcium-
buttonup
buttonup
120,50,100
Yes - especially Rennies and the like, which
are 'over the counter' treatments and often forgotten about.
These can cause the 'milk-alkali' syndrome, which should
probably be renamed the 'calcium-alkali' syndrome.
Antacids
"Yes, thiazides cause hypercalcaemia
Hcausing"&&\
"sodium/ECF volume depletion. This
turn
said
"increase calcium reabsorption
Hthe proximal renal tubule."&&\
"For some reason lop diuretics DO NOT
buttonup
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120,50,100
Yes, thiazides cause hypercalcaemia by causing
sodium/ECF volume depletion. This in turn is said to
increase calcium reabsorption by the proximal renal tubule.
For some reason lop diuretics DO NOT cause hypercalcaemia.
Diuretics
"No."
buttonup
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0,50,100
Digoxin
Eight
,#>b
"No."
buttonup
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Beta Blockers
seven
"No."
buttonup
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0,50,100
Calcium Antagonists
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Browse Forwards.
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"answer1"
c"PTH"
"Yes. Parathyroid Hormone,(
correct."&&\
"The
; would be raised.
now assaying
you will receive
results
due course."
c"serum
PTH),
response1
"Wrong. You answered" &&
".
buttonUp
buttonUp
alphacheck
answer1
Yes. Parathyroid Hormone,(PTH), is correct.
The PTH would be raised. The lab is now assaying for PTH
and you will receive the results in due course.
answer1
answer1
serum PTH
Yes. Parathyroid Hormone,(PTH), is correct.
The PTH would be raised. The lab is now assaying for PTH
and you will receive the results in due course.
answer1
answer1
serum Parathyroid Hormone
Yes. Parathyroid Hormone,(PTH), is correct.
The PTH would be raised. The lab is now assaying for PTH
and you will receive the results in due course.
answer1
answer1
Parathyroid Hormone
Yes. Parathyroid Hormone,(PTH), is correct.
The PTH would be raised. The lab is now assaying for PTH
and you will receive the results in due course.
answer1
answer1
Wrong. You answered
. Parathyroid Hormone,(PTH), is correct.
The PTH would be raised. The lab is now assaying for PTH
and you will receive the results in due course.
response1
Considering Diagnoses
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Accept answer
answer1
pthtext
How to type in your answer
Click in the yellow box and
type the test name which would confirm the diagnosis of hyperparathyroidism (you can use an abbreviation if you want).
If you make a mistake you can type over or delete the word.
When you are satisfied with your answer click on the 'Accept Answer' button.
HypercalcText
It turns out that, apart from the bendrofluazide, she is on no therapy. Except that is, for Rennies which she takes "on occasion".
On closer history taking, it emerges that the back pain was sudden in onset and precipitated by lifting a heavy weight. There is nil to find on examination apart from a mild kyphosis. BP is normal at 150/85.
What diagnoses are you considering ?
(Hint: at least 2 are possible.)one of which unlikely.)
txclassname
3DFrame Recessed
"Thiazide could be responsible
the hypercalcaemia."
buttonup
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120,50,100
Thiazide could be responsible for the hypercalcaemia.
Thiazide induced
"Unlikely. There
nothing
exam"&&\
suggest sarcoid."
buttonup
buttonup
0,50,100
Unlikely. There is nothing in the history or exam
to suggest sarcoid.
Sarcoid
"Very possible
otherwise well"&&\
"patient
fhypercalcaemia."
buttonup
buttonup
120,50,100
Very possible in an otherwise well
patient with hypercalcaemia.
Hyperparathyroidism
Three
"Possible but unlikely. These patients are almost"&&\
"always alkalotic (
)'s C02
lowish)
have"&&\
"renal impairment.
They also
be taking a "&&\
Rennies etc. (2-3 pkts per day)."
buttonup
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60,50,100
Possible but unlikely. These patients are almost
always alkalotic (this patient's C02 is lowish) and have
renal impairment. They also have to be taking a
lot of Rennies etc. (2-3 pkts per day).
Milk-alkali syndrome
"Unlikely
view
the negative clinical exam
ormal albumin."
buttonup
buttonup
0,50,100
Unlikely in view of the negative clinical exam and
the normal albumin.
Cancer
"No. These patients are hypotensive usually
have other"&&\
"electrolyte abnormalities (low Na, high K)."
buttonup
buttonup
0,50,100
No. These patients are hypotensive usually and have other
electrolyte abnormalities (low Na, high K).
Addison's disease
answerbox1
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Likely Diagnosis after Testing
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Nothing
No - some sort of follow up would be indicated.
MonitorCalcium
Yes - check weekly. Also, think
about giving prophylaxis.
GiveProphylaxis
A good suggestion, although life expectancy of these patients is short and not all will need prophylaxis. Monitoring calcium is also recommended.
HypercalcText
OK. You have a patient with osteoporosis, fractures and hypercalcaemia. She is also hypertensive. The result of the PTH has just come back and is 8 ng/l (normal 2-8). Her ESR is 10 (normal).
What is the likely diagnosis ? by lifting a heavy weight.
There is nil to find on examination apart from a mild kyphosis. BP is normal at 150/85.
What diagnoses are you considering ?
"Rare but possible; PTH levels
usually detectable"&&\
sometimes raised
condition. Exclude
Hmeasurement"&&\
fasting urine ratio
calcium/creatinine"&&\
<0.01 suggests FHH)."
buttonup
buttonup
60,50,100
Rare but possible; PTH levels are usually detectable
and sometimes raised in this condition. Exclude by measurement
of fasting urine ratio of calcium/creatinine
(ratio<0.01 suggests FHH).
Familial Hypocalciuric Hypercalcaemia
"No. Although a cause
unlikely"&&\
%she has a
wESR, (
= 10),"&&\
wglobulin."
buttonup
buttonup
0,50,100
No. Although a cause it is unlikely
in this case as she has a normal ESR, (ESR = 10),
and normal globulin.
Myeloma
Three
"No. Although a possible cause
hypercalcaemia"&&\
"there
no clinical evidence
Hyperthyroidism."
buttonup
buttonup
0,50,100
No. Although a possible cause of hypercalcaemia
there is no clinical evidence for Hyperthyroidism.
Hyperthyroidism
B"one"
"Almost certainly yes. The PTH
)the upper limit
innapropriate
'hypercalcaemia,
%"&&\
"such indicates parathyroid overactivity.
A rare, but"&&\
"possible alternative diagnosis could be familial"&&\
"hypocalciuric
buttonup
buttonup
120,50,100
Almost certainly yes. The PTH at the upper limit of
normal is innapropriate to the hypercalcaemia, and as
such indicates parathyroid overactivity. A rare, but
possible alternative diagnosis could be familial
hypocalciuric hypercalcaemia.
Primary hyperparathyroidism
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Nothing
No - some sort of follow up would be indicated.
MonitorCalcium
Yes - check weekly. Also, think
about giving prophylaxis.
GiveProphylaxis
A good suggestion, although life expectancy of these patients is short and not all will need prophylaxis. Monitoring calcium is also recommended.
HypercalcText
OK. You have a patient with osteoporosis, fractures and hypercalcaemia. She is also hypertensive. The result of the PTH has just come back and is 8 ng/l (normal 2-8). Her ESR is 10 (normal).
What is the likely diagnosis ? by lifting a heavy weight.
There is nil to find on examination apart from a mild kyphosis. BP is normal at 150/85.
What diagnoses are you considering ?
"Rare but possible; PTH levels
usually detectable"&&\
sometimes raised
condition. Exclude
Hmeasurement"&&\
fasting urine ratio
calcium/creatinine"&&\
<0.01 suggests FHH)."
buttonup
buttonup
60,50,100
Rare but possible; PTH levels are usually detectable
and sometimes raised in this condition. Exclude by measurement
of fasting urine ratio of calcium/creatinine
(ratio<0.01 suggests FHH).
Familial Hypocalciuric Hypercalcaemia
"No. Although a cause
unlikely"&&\
%she has a
wESR, (
= 10),"&&\
wglobulin."
buttonup
buttonup
0,50,100
No. Although a cause it is unlikely
in this case as she has a normal ESR, (ESR = 10),
and normal globulin.
Myeloma
Three
"No. Although a possible cause
hypercalcaemia"&&\
"there
no clinical evidence
Hyperthyroidism."
buttonup
buttonup
0,50,100
No. Although a possible cause of hypercalcaemia
there is no clinical evidence for Hyperthyroidism.
Hyperthyroidism
B"one"
"Almost certainly yes. The PTH
)the upper limit
innapropriate
'hypercalcaemia,
%"&&\
"such indicates parathyroid overactivity.
A rare, but"&&\
"possible alternative diagnosis could be familial"&&\
"hypocalciuric
buttonup
buttonup
120,50,100
Almost certainly yes. The PTH at the upper limit of
normal is innapropriate to the hypercalcaemia, and as
such indicates parathyroid overactivity. A rare, but
possible alternative diagnosis could be familial
hypocalciuric hypercalcaemia.
Primary hyperparathyroidism
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Results
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Na 145
Urea 6.5
Creat 100
Alk P 80
ggt GGT 24
Albumin 45
Globulin 28
Calcium 2.85
AST 24
CO2 25
K 3.4 Bil 12
Phosphate 0.8 mmol/l
"Sorry, try
buttonUp
buttonUp
Sorry, try again
"Sorry, try
buttonUp
buttonUp
Sorry, try again
"Yes, the serum calcium
slightly elevated."&&\
"None
0other tests are relevant
Lproblem."
buttonUp
buttonUp
Yes, the serum calcium is slightly elevated.
None of the other tests are relevant to the problem.
typed
Na 145
K 3.4
CO2 25
Urea 6.5
Creat 100
AST 24
Bil 12
ALkP 80
GGT 24
Albumin 45
Calcium 2.85
Globulin 28
Phosphate 0.8 mmol/ll
"Yes, the serum calcium
slightly elevated."&&\
"None
.other results are relevant
Lproblem."
buttonUp
buttonUp
Yes, the serum calcium is slightly elevated.
None of the other results are relevant to the problem.
"Sorry, try
buttonUp
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Sorry, try again
"Sorry, try
buttonUp
buttonUp
Sorry, try again
typedhelp
Look at the
original letter.. handwriting by clicking here.
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B"helpbutton"
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Look at the blood results which he has written on the back of the letter. Click on the result(s) which might be relevant to the problem..
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Thiazide Experiment Results
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You stop the thiazide and see the patient in 4 weeks. Her blood pressure is now 160/105. Look at the blood results.
5 mmol/l; K 3.9 mmol/l; C02 25; Urea 4.5 mmol/l;
Creat 90
mol/l, Albumin 46 g/l; Calcium 2.9 mmol/l; phosphate 0.75 mmol/l
now ? (you may choose to do more than just one thing).
Was it the thiazide causing the hypercalcaemia ?
"Correct,
since
was"&&\
"controlling
&hypertension."
buttonup
buttonup
120,50,100
Correct, put her back on it since it was
controlling her hypertension.
"Wrong, you should
since
was"&&\
"controlling
&hypertension."
buttonup
buttonup
0,50,100
Wrong, you should put her back on it since it was
controlling her hypertension.
New Results:
BP 160/105
Na 145 mmol/l
K 3.9 mmol/l
C02 25
Urea 4.5 mmol/l
Creat 90
mol/l
Albumin 46 g/l
Calcium 2.9 mmol/l Phosphate 0.75 mmol/llllllll'
Original Results:
BP 150/85
Na 145 mmol/l
K 3.4 mmol/l
C02 25
Urea 6.5 mmol/l
Creat 100
mol/l
Albumin 45 g/l
Calcium 2.85 mmol/l; Phosphate 0.8 mmol/lll
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"No."
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Calcium Antagonists
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Possible Thiazide Involvement
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The possible diagnoses are Milk-Alkalai syndrome, (unlikely), hyperparathyroidism, (possible), and thiazide induced, (possible).
How would you investigate the possible involvement of thiazide ? ? his further?
Check urine calcium
Stop treatment to see what happens
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Check serum thiazide
levels to see if they
are raised
Check PTH
Serum thiazide: No. a good lawyer - you'll need one for the GMC hearing and the litigation.
Urine calcium: Not useful unless you suspect familial hypocalciuric hypercalcaemia.nt in hypercalcaemia.
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Stop treatment: Yes - and repeat calcium after 2-4 weeks. See also 'Check PTH'....
PTH: Yes - it would be low in true thiazide hypercalcaemia. I would try stopping the drug first though. See also 'Stop treatment'.
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