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<TITLE>SilverPlatter-OSH ROM</A> [<I>SilverPlatter-OSH ROM</I>] </TITLE><PRE>
1 of 133
TI: Mortality of 11,500 nickel workers - Extended follow up and relationship
to environmental conditions
AU: Shannon-HS; Walsh-C; Jadon-N; Julian-JA; Weglo-JK; Thornhill-PG; Cecutti-
AG
LA: English
SO: Toxicology and Industrial Health; 1991, Vol.7, No.4, p.277-294. 13 ref.
PY: 1991
AB: An extended follow-up from 1977-84 was achieved in a cohort of 11,567
nickel workers engaged in mining, milling and smelting originally studied
during 1950-76. Exposure data were incorporated into the analysis. One case of
nasal cancer occurred. The lung cancer Standardised Mortality Ratio beyond 15
years from first exposure was significantly high overall (128) and in miners
(153). However, detailed analyses by era of first mining and duration of
mining, as well as cumulative exposure to different nickel species, did not
appear consistent with an occupational aetiology since significant trends were
not observed. At the levels of exposure incurred in nickel refineries
elsewhere, no large increases in lung and nasal cancer were observed.
DA: MORTALITY-; NICKEL-; NEOPLASMS-; OCCUPATION-DISEASE-RELATION
DE: EPIDEMIOLOGIC-STUDY; METAL-MINING; SMELTING-PLANTS; MILLING-INDUSTRY;
LUNG-CANCER; NASAL-CANCER; CANADA-; ONTARIO-
CAS: 7440-02-0
SC: Metal-producing-and-metal-working-industries
SP: Hygiene
AN: 92-1925
RN: 059044
2 of 133
TI: Comparative studies on the carcinogenicity of nickel, different nickel
compounds and nickel alloys
TO: Vergleichende Untersuchungen uber die Kanzerogenitat verschiedener
Nickelverbindungen und Nickellegierungen
AU: Pott-F; Rippe-RM; Roller-M; Rosenbruch-M; Huth-F; Bundesanstalt fur
Arbeitsschutz
LA: German
SO: Wirtschaftsverlag NW, Postfach 10 11 10, Am Alten Hafen 113-115, D-W-2850
Bremerhaven 1, Germany, 1991. 59p. Illus. 45 ref.
IS: 3894291249
PY: 1991
AB: This study is divided into two sections. I. - Bibliographical review (in
tabular form) of the carcinogenic effects on animals of nickel (Ni), nickel
compounds and nickel alloys. II - Assessment, through animal experiments, of
the carcinogenicity of nickel powder, and of six nickel compounds (chloride,
sulfate, acetate, carbonate, subsulfide, oxide) as well as 3 nickel alloys.
Highly soluble nickel compounds (Ni-chloride, -sulfate, -acetate) were very
toxic but only weakly carcinogenic. Ni-subsulfide showed a lower toxicity but
the strongest carcinogenicity of all tested substances (inducement of sarcomas
and mesotheliomas in 56% of animals from 6mg Ni). Higher doses (25 to 50mg Ni)
of two nickel alloys containing 50% or 66% of nickel oxide produced a
carcinogenic but no toxic effect. 100mg Ni injected with a nickel alloy
containing 29% Ni and 160mg of two iron oxides were not proven to be
carcinogenic. Summaries in English, French and German.
DA: CARCINOGENS-; HAZARD-EVALUATION; NICKEL-AND-COMPOUNDS; CARCINOGENIC-
EFFECTS; NICKEL-; NICKEL-ALLOYS
DE: LITERATURE-SURVEY; ANIMAL-EXPERIMENTS
CAS: 7440-02-0; 7786-81-4; 373-02-4; 3333-67-3; 12035-72-2; 1313-99-1; 7718-
54-9
SC: Toxic-and-dangerous-substances
SP: Hygiene
AN: 92-1264
RN: 058345
CN: Forschungsbericht Nr.638
</PRE>