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<TITLE>MicroPatent-CAPS</A> [<I>MicroPatent-CAPS</I>] </TITLE><PRE>
Patent Number 5186913
Issue Date 1993 02 16
Appl. Data 692110 1991 04 26
Assignee Martin Marietta Energy Systems, Inc.
Inventor(s) Knapp, Jr., Furn F.
Lisic, Edward C.
Mirzadeh, Saed
Callahan, Alvin P.
State/Country TN
Title Tungsten-188/carrier-free rhenium-188 perrhenic acid
generator system
Abstract A generator system for providing a carrier-free
radioisotope in the form of an acid comprises a
chromatography column in tandem fluid connection with an
ion exchange column, the chromatography column containing a
charge of a radioactive parent isotope. The chromatography
column, charged with a parent isotope, is eluted with an
alkali metal salt solution to generate the radioisotope in
the form of an intermediate solution, which is passed
through the ion-exchange column to convert the radioisotope
to a carrier-free acid form.
Exmp. Claim 1
Ex Claim text A method for generating carrier-free Re-188 perrhenic acid
comprising the steps of:
providing a chromatography column and a cation-exchange
column;
applying to said chromatography column a charge of W-188;
eluting said chromatography column with a metal salt
solution to generate Re-188 in the form of an intermediate
solution; and,
passing said intermediate solution through said
cation-exchange column to convert said Re-188 to a
carrier-free acid form.
U.S. Class 423/2 423/249 423/49 423/54 424/1.1 250/423PD
IPC C01G 41/00 C01G 47/00
U.S. Refs 4280053 4521381 4572823 4599223 4683123 4859431
4935222 5021235
Foreign Refs GBX 197809 2005651A
GBX 197809 2009119A
Other Refs Ehrhardt et al "An Improved Tungsten-188/Rhenium-188
Generator for Radiotherapeutic Applications," Proc. of 34th
Ann. Mtg, Society of Nucl. Medicine, Abs. #416, J. Nucl.
Med. 28; 4, pp. 656,657 (1987).
A. P. Callahan et al "Availability of Rhenium-188 . . .
from a Tungsten-188/Re- 188 Generator for Therapeutic
Applications," Ibid; Abs. #417.
R. E. Lewis. "Production of 70-Day Tungsten-188 and
Development of a 17 Hour Rhenium-188 Radioisotope
Generator," J. Nucl. Med. 7, pp. 804-805 (1966).
R. L. Hayes et al, "Rhenium-188 as a Possible Diagnostic
Agents," Oak Ridge Associated Universities Medical Division
Report, ORAU 101, pp. 74-77 (1966).
Mikheev et al, U.S.S.R. publication, pp. 248-251, 1972.
J. Blachot et al, International Journal of Applied
Radiation and Isotopes, 20, pp. 467-470 (1969).
Examiner Stoll, Robert L.
Agent Marasco, J. A.
Adams, H. W.
Image Disc # This patent is on PatentImages disc# 1993\014 and
PatentImages(chemical) disc# 1993\c05
</PRE>