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1994-08-27
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Document 0662
DOCN M9480662
TI Langerhans cell histiocytosis: lack of a viral etiology.
DT 9410
AU McClain K; Jin H; Gresik V; Favara B; Baylor College of Medicine, Texas
Children's Hospital, Houston; 77030.
SO Am J Hematol. 1994 Sep;47(1):16-20. Unique Identifier : AIDSLINE
MED/94317638
AB Langerhans cell histiocytosis (LCH) is an enigmatic histiocytic
proliferative disorder of unknown etiology that affects children
primarily. We have investigated the possibility that viruses are
etiological or that they have a triggering effect in LCH. Sensitive in
situ hybridization and polymerase chain reaction (PCR) techniques were
used in 56 cases of LCH. We sought and failed to find evidence of
genomes for adenovirus, cytomegalovirus, Epstein-Barr virus, herpes
simplex virus, human herpesvirus type 6, human immunodeficiency virus,
human T-cell leukemia virus types I and II, and parvovirus. Although
some probes hybridized to tissues from several cases, PCR failed to
confirm the presence of viral genome in any. We conclude that there is
no evidence that these viruses are associated with LCH.
DE Adenovirus Infections, Human/COMPLICATIONS Base Sequence Child Child,
Preschool Cytomegalovirus Infections/COMPLICATIONS Genes,
Viral/GENETICS Herpesviridae Infections/COMPLICATIONS Herpesvirus 4,
Human Histiocytosis, Langerhans-Cell/*ETIOLOGY/GENETICS/MICROBIOLOGY
Human HIV Infections/*COMPLICATIONS In Situ Hybridization Molecular
Sequence Data Parvoviridae Infections/COMPLICATIONS Polymerase Chain
Reaction Support, Non-U.S. Gov't Tumor Virus Infections/COMPLICATIONS
Virus Diseases/*COMPLICATIONS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).