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- Comments: Gated by NETNEWS@AUVM.AMERICAN.EDU
- Path: sparky!uunet!paladin.american.edu!auvm!NIHCU.BITNET!BFU
- Message-ID: <CFS-L%93011923334042@LIST.NIH.GOV>
- Newsgroups: alt.med.cfs
- Date: Tue, 19 Jan 1993 23:30:37 EST
- Sender: Chronic Fatigue Syndrome discussion CFIDS/ME
- <CFS-L@NIHLIST.BITNET>
- From: Roger Burns <BFU@NIHCU.BITNET>
- Subject: Nutrasweet/CFS
- Lines: 73
-
- I posted a query about aspartame (NutraSweet) & its relation to CFS
- to the immune list the other day; below I copy an interesting response.
- Please post any comments you may have about this topic to this list.
-
-
- Roger Burns bfu@cu.nih.gov / bfu@nihcu.bitnet / fidonet 1:109/432
- List-owner, Chronic Fatigue Syndrome discussion
- CFS-L on LISTSERV at NIHLIST.BITNET or LIST.NIH.GOV
- Newsgroup: alt.med.cfs
-
- == Forwarded Mail ==
-
- Date: 19 Jan 93 07:17:24 EST
- From: Pat Wilcox <71340.142@CompuServe.COM>
- To: <immune@weber.ucsd.edu>
- Subject: Nutrasweet/CFS
-
- > Date: 19-Jan-93 02:53 EST
- > From: "Roger Burns" >INTERNET:BFU@CU.NIH.GOV
- > Subj: aspartame (NutraSweet) and chronic fatigue syndrome
-
- > I've read a message on the Fidonet CFS echo which claims that
- > the FDA has information pegging aspartame (NutraSweet) as the
- > cause of chronic fatigue syndrome.
-
- As A cause of chronic fatigue syndrome, not THE cause (look at your
- posting again).
-
- > I have a guess that this
- > is an idea that has already been well discussed but I personally
- > haven't heard of this before. Can anyone fill me in on this?
- > If it is a new claim then I'm inclined to do a lot of phone
- > calling to trace down what this is about.
-
- I've never heard of this before, either, but it's consistent with
- a reference I found last week which lists the amino acid phenylala-
- nine (one component of aspartame) as an inhibitor of the pyruvate
- kinase (PK) enzyme. My model of CFS says that anything that interrupts
- glycolysis (glucose metabolism) will cause the symptoms of CFS (which
- appear to be identical with the symptoms of recurrent episodes of
- glutathione depletion). PK catalyzes the final step of anaerobic
- glycolysis; the glycolytic pathway is intimately involved in gluta-
- thione metabolism.
-
- Studies show that about 1.4% to 1.8% of Northern Europeans are heterozy-
- gotes for PK deficiency, and Valentine et al. in _The Metabolic
- Basis of Inherited Disease_(1989) say that there are even more cases of
- acquired PK deficiency than the inherited variety -- say maybe 5% of
- the population altogether? Certain chemotherapy drugs, and at least
- one of the Polysorbates, are known to inhibit PK. Actually, I'm bet-
- ting that anything with -sorb- in the name (Polysorbate 80, Polysorbate
- 60, sorbitol, sorbitan, sorbic acid) will turn out to inhibit PK. Stay
- away from frozen yogurt and most ice creams, pickles, grated cheese,
- some brands of cottage cheese, most kinds of toothpaste, and sweet corn
- if you have a PK problem. And that's just for starters. I had a bad
- reaction to sublingual B12 tablets which contained sorbitol. Many of
- these things aren't required to list ingredients, and it's hard to find
- out what's in them. 8-(
-
- > Roger Burns bfu@cu.nih.gov / bfu@nihcu.bitnet / fidonet 1:109/432
- > Editor, CFS-NEWS Chronic Fatigue Syndrome Electronic Newsletter
- > CFS-NEWS on LISTSERV at NIHLIST.BITNET or LIST.NIH.GOV
- > newsgroup: bit.listserv.cfs.newsletter
-
- > ======= COPY OF ECHO MESSAGE (part) =================================
- > ...
-
- > I'm new here but I happen to have next to my computer the Drl Lendon
- > Smith's "the Facts" for Oct 91. It says per the Aspartame Consumer
- > Safety Network
- > (ACSN, PO Box 780634, Dallas, TX 75378) that there is FDA information
- > of Aspertane (ASP/Nutrasweet/Equal) has been known to cause Chronic
- > Fatigue Syndrome.
-