PyGTK is an extension module for python that gives you access to the GTK+ widget set. Just about anything you can write in C with GTK+ you can write in python with PyGTK (within reason), but with all of python's benefits.
gnome-python-1.0.3: description + notes
PyGNOME is an extension module for python that gives you access to the base GNOME libraries. This means you have access to more widgets, simple configuration interface, metadata support and many other features.
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