Tweaks
Disk
IO Page Lock Limit
If your system is very IO intensive you can increase the amount of memory that can be locked for IO operations when data is read from or written to the hard disks. When this value is 0, the system uses the default (512 Kbytes). Raising this value can give you a significant performance boost.
Disable NTFS last access update
By enabling this option, NT Filesystem will not record the last time a file was accessed. This can speed up disk operations if applications write many small files very frequently.
Miscellaneous
Hung App Timeout
Windows waits by default a long time to finally acknowledge that a particular program is "Not responding", and only after that allowing you to shut it down by clicking the End Task button.
Wait to Kill App Timeout
This value sets the timeout until Windows shuts down/restarts, while trying to exit all open programs.
Show Menu Delay
Decreasing this value makes the Start Menu cascading menus appear more quickly.
Enable Filename completion
Filename completion is a popular feature of many UNIX shells that saves keystrokes. It is disabled by default in Windows 2000. In a dos console window, if you type the first few letters of a filename and then press the tab key, a matching filename will appear on the command line.