Perl for ISAPI is a plug-in designed to run Perl scripts faster on ISAPI compliant Web servers. Requires Perl for Win32 Core and an ISAPI compliant Web server such as Microsoft Internet Information Server 3.0/4.0
When you launch the ActivePerl installer, Perl for ISAPI is one of the components you can optionally install. You must install, or have previously installed, Perl for Win32 to use Perl for ISAPI.
The Perl for Win32 FAQ has a useful section on Perl for ISAPI. You can find it here.