Ms. Leeson's work over the past 30 years has included photography, film, computer-interactive installations, performance and video. All of her work questions the idea of truth. She often employs the documentary format to achieve this.

She has had over 150 exhibitions in museums and galleries throughout the world, including The Museum of Modern Art (New York and Paris), The Whitney Museum of American Art, and the ICA, London. She is considered a pioneer of many art forms, having produced the first interactive laser disk in 1979.