CBM 92-9 MULTIDRUG RESISTANCE January 1988 through September 1992 2250 Citations Prepared by: Loretta D. Ulincy, M.L.S., National Library of Medicine Michael M. Gottesman, M.D., National Cancer Institute U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health National Library of Medicine Reference Section 8600 Rockville Pike Bethesda, Maryland 20894 1992 SERIES NOTE Current Bibliographies in Medicine (CBM) is a continuation in part of the National Library of Medicine's Literature Search Series, which ceased in 1987 with No. 87-15. In 1989 it also subsumed the Specialized Bibliography Series. Each bibliography in the new series covers a distinct subject area of biomedicine and is intended to fulfill a current awareness function. Citations are usually derived from searching a variety of online databases. NLM databases utilized include MEDLINEþ, AVLINEþ, BIOETHICSLINEþ, CANCERLITþ, CATLINEþ, HEALTH, POPLINEþ and TOXLINEþ. The only criterion for the inclusion of a particular published work is its relevance to the topic being presented; the format, ownership, or location of the material is not considered. Comments and suggestions on this series may be addressed to: Karen Patrias, Editor Current Bibliographies in Medicine Reference Section National Library of Medicine Bethesda, MD 20894 Phone: 301-496-6097 Fax: 301-402-1384 Internet: patrias@nlm.nih.gov Ordering Information: Current Bibliographies in Medicine is sold by the Superintendent of Documents, U.S. Government Printing Office, Washington, D.C. 20402. To order the entire CBM series for the calendar year 1992 (approx. 14 bibliographies), send $41.00 ($51.25 foreign) to the Superintendent of Documents citing GPO List ID: CBM92. Orders for individual bibliographies in the series ($3.25, $4.06 foreign) should be sent to the Superintendent of Documents citing the title, CBM number, and the GPO List ID given above. MULTIDRUG RESISTANCE The resistance of cancer cells to multiple chemotherapeutic drugs which are structurally unrelated has been termed "multidrug resistance." In the past several years, several mechanisms of multidrug resistance have been described, including the expression of a cell surface multidrug efflux pump (P-glycoprotein or the multidrug transporter), altered glutathione metabolism, reduced activity of topoisomerase II, and various less clearly defined changes in cellular proteins. Because of evidence that expression of P-glycoprotein is associated with drug-resistance in cancer, P-glycoprotein has been studied extensively from the point of view of its biochemistry and mechanism of action in order to develop inhibitors which can be used clinically to reverse drug resistance of cancers in patients. The clinical significance of the other mechanisms of multidrug resistance are less well- established, but many model systems indicate that they may contribute to clinical resistance. This bibliography lists journal articles, conference proceedings and abstracts, letters, and monographs published from January 1988 through September 1992. Arrangement of the bibliography is by mechanism of this resistance (or by the fact that a novel, but unknown mechanism is responsible for resistance), and deals with both the basic biochemistry and the clinical implications of these mechanisms. The P- glycoprotein section is further subdivided by neoplasm type and by antineoplastic/immunosuppressive drug categories. Citations may be in more than one category. The monographs are listed in a separate category at the end of the bibliography. SEARCH STRATEGY A variety of online databases are usually searched in preparing bibliographies in the CBM series. To assist you in updating or otherwise manipulating the material in this search, the strategy used for the NLM's MEDLINE database is given below. Please note that the search strategies presented here differ from individual demand searches in that they are generally broadly formulated and irrelevant citations edited out prior to printing. SS 1 = (TW) MULTIPLE AND DRUG AND ALL RESISTAN: SS 2 = (TW) MDR OR MDR1 SS 3 = (TW) MULTIDRUG AND ALL RESISTAN: SS 4 = (TW) MULTI AND DRUG AND ALL RESISTAN: SS 5 = P-GLYCOPROTEIN (NM) OR GP170 (TW) SS 6 = EXP DRUG RESISTANCE SS 7 = 6 AND MULTI (TW) OR 6 AND MULTIDRUG (TW) OR 6 AND MULTIPLE (TW) SS 8 = 1 OR 2 OR 3 OR 4 OR 5 OR 7 SS 9 = 8 AND NEOPLASMS (PX) OR 8 AND ALL CHEMOTHERAP: (TW) OR 8 AND EXP ANTINEOPLASTIC AGENTS OR 8 AND TUMOR NECROSIS FACTOR OR 8 AND EXP GENE EXPRESSION OR 8 AND DNA, NEOPLASM OR 8 AND EXP TUMOR CELLS, CULTURED SS 10 = 8 AND EXP MUTAGENESIS, SITE DIRECTED OR 8 AND RNA, NEOPLASM OR 8 AND SEQUENCE ALIGNMENT OR 8 AND EXP MOLECULAR SEQUENCE DATA OR 8 AND EXP PHENOTYPE SS 11 = 8 AND EXP DNA OR 8 AND EXP DNA PROBES SS 12 = 8 AND GENETICS (SH) SS 13 = 9 OR 10 OR 11 OR 12 GRATEFUL MEDþ To make online searching easier and more efficient, the Library offers GRATEFUL MED, microcomputer-based software that provides a user-friendly interface to most NLM databases. This software was specifically developed for health professionals and features multiple choice menus and "fill in the blank" screens for easy search preparation. GRATEFUL MED runs on an IBM PC (or IBM-compatible) with DOS 2.0 or a Macintosh, and requires a Hayes (or Hayes-compatible) modem. It may be purchased from the National Technical Information Service in Springfield, Virginia, for $29.95 (plus $3.00 per order for shipping). SAMPLE CITATIONS Citations in this bibliographic series are formatted according to the rules established for Index Medicusþ*. Sample journal and monograph citations appear below. For journal articles written in a foreign language, the English translation of the title is placed in brackets; for monographs, the title is given in the original language. In both cases the language of publication is shown by a three letter abbreviation appearing at the end of the citation. Note also that a colon (:) may appear within an author's name or article title. The NLM computer system automatically inserts this symbol in the place of a diacritical mark. Journal Article: Authors Article Title LaQuaglia MP, Kopp EB, Spengler BA, Meyers MB, Biedler JL. Multidrug resistance in human neuroblastoma cells. J Pediatr Surg 1991 Sep; 26(9):1107-12. Abbreviated Journal Date Volume Issue Pages Title Monograph: Authors/Editors Title Chou, T.C.; Rideout, D.C., editors. Synergism and antagonism in chemotherapy. New York: Academic Press; 1991. 752 p. Place of Publisher Date Total No. Publication of Pages _________________________________ *For details of the formats used for references, see the following publication: Patrias, Karen. National Library of Medicine recommended formats for bibliographic citation. Bethesda (MD): The Library; 1991 Apr. Available from: NTIS, Springfield, VA; PB91-182030. TABLE OF CONTENTS P-Glycoproteins By Neoplasm Type Brain neoplasms Breast neoplasms Colorectal neoplasms Fibrosarcomas Kidney neoplasms Leukemias Liver neoplasms Lung neoplasms Lymphomas Myelomas Prostate neoplasms Neoplasms (other specific) Neoplasms (general) By Antineoplastic/Immunosuppressive Agent Type Anthracyclines Antimetabolites Immunosuppressive agents Nitrogen mustard compounds Phytogenic compounds Other antineoplastic agents Other Glutathione Topoisomerase Unknown Mechanism Other Monographs P-GLYCOPROTEIN By Neoplasm Type -Brain neoplasms Akiyama SI, Tisgunyram A, Ichikawa M, Sumizawa T, Furukawa T. A molecular basis for multidrug-resistance and reversal of the resistance. In: Tabuchi K, editor. Biological aspects of brain tumors. 8th Nikko Brain Tumor Conference; 1990 Nov 6- 8; Karatsu-shi, Japan. New York: Springer-Verlag; 1991. p. 63-72. Bates SE, Shieh CY, Tsokos M. Expression of mdr-1/P- glycoprotein in human neuroblastoma. Am J Pathol 1991 Aug;139(2):305-15. Bates SE, Mickley LA, Chen YN, Richert N, Rudick J, Biedler JL, Fojo AT. Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid- induced differentiation. Mol Cell Biol 1989 Oct;9(10):4337-44. Becker I, Becker KF, Meyermann R, Hollt V. The multidrug- resistance gene MDR1 is expressed in human glial tumors. Acta Neuropathol (Berl) 1991; 82(6):516-9. Benard J, Bourhis J, Hartmann O, Boccon-Gibod L, Duvillard P, Lhomme C, Michel G, Lemerle J, Goldstein L, Gottesman M, et al. Overexpression of human MDR1 gene is related to prior chemotherapy in ovarian carcinomas and in neuroblastomas. Paper presented at: Symposium on Mechanisms of Drug and Radiation Resistance of Tumor Cells; 1989 Jun 28-30; Villejuif, France. Benard J, Bourhis J, Riou G. [Activation of N-myc oncogene and associated genes to chemoresistance, prognostic value for neuroblastoma]. Bull Cancer (Paris) 1991 Jan;78(1):91-7. (Fre). Biedler JL, Casals D, Chang TD, Meyers MB, Spengler BA, Ross RA. Multidrug-resistant human neuroblastoma cells are more differentiated than controls and retinoic acid further induces lineage-specific differentiation. Prog Clin Biol Res 1991;366:181-91. Bourhis J, Benard J, Hartmann O, Boccon-Gibod L, Lemerle J, Riou G. Correlation of mdr1 gene expression with chemotherapy in neuroblastoma. J Natl Cancer Inst 1989;81(18):1401-5. Bradley G, Georges E, Ling V. Immunohistochemical localization of P-glycoprotein isoforms [abstract]. J Chemother Infect Dis Malig 1989;Suppl 1:A306. Chan HS, Haddad G, Thorner PS, Deboer G, Lin YP, Ondrusek N, Yeger H, Ling V. P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma. N Engl J Med 1991;325(23):1608-14. Chan HS, Thorner PS, Weitzman S, Solh H, Koren G, Thiessen J, Haddad G, Giesbrecht E, Verjee Z, Greenberg ML, et al. Cyclosporin A for reversal of multidrug resistance in childhood malignancies [abstract]. Proc Annu Meet Am Assoc Cancer Res 1992;33:A2854. Cordon-Cardo C, O'Brien JP, Boccia J, Casals D, Bertino JR, Melamed MR. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 1990 Sep;38(9):1277-87. Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR. Multidrug-resistance gene p- glycoprotein is expressed by endothelial cells at blood- brain barrier sites. Proc Natl Acad Sci U S A 1989;86(2):695-8. Doz F, Michon J, Quintana E, Pacquement H, Zucker JM. [Multidrug resistance of solid tumors in children]. Arch Fr Pediatr 1991 Oct;48(8):585-8. (Fre). Feun L, Landy H, Lu K, Li DJ, Kuo MT, Lampidis T, Green B, Savaraj N. MDR1 gene expression in primary malignant brain tumor (MBT) [abstract]. Proc Annu Meet Am Soc Clin Oncol 1989;8:A343. Fleming GF, Amato JM, Agresti M, Safa AR. Megestrol acetate reverses multidrug resistance and interacts with P- glycoprotein. Cancer Chemother Pharmacol 1992;29(6):445-9. Goldstein L, Galski H, Fojo A, Willingham M, Lai SL, Gazdar A, Pirker R, Green A, Crist W, et al. Expression of a multidrug resistance gene in human cancers. J Natl Cancer Inst 1989;81(2):116-24. Goldstein L, Galski H, Fojo A, Willingham M, Green A, Crist W, Gottesman M, Pastan I. Expression of a multidrug- resistance gene in human tumors [abstract]. Proc Annu Meet Am Assoc Cancer Res 1988;29:A1184. Goldstein LJ, Fojo AT, Ueda K, Crist W, Green A, Brodeur G, Pastan I, Gottesman MM. Expression of the multidrug resistance, MDR1, gene in neuroblastomas. J Clin Oncol 1990 Jan; 8(1): 128-36. Gottesman MM, Goldstein LJ, Pastan I. Expression of the multidrug-resistance (MDR1) gene in breast cancer and other cancers. Paper presented at: Biennial International Breast Cancer Research Conference; 1989 Mar 5-9; Tel Aviv University, Tel Aviv. Gottesman MM, Goldstein LJ, Willingham MC, Pastan I. Molecular biology of a human multidrug transporter. Paper presented at: Molecular Diagnostics of Human Cancer. Cold Spring Harbor Meeting on Cancer Cells; 1988 Sep 7-11; Cold Spring Harbor, NY. Gottesman MM, Pastan I. A membrane protein that transports natural product cytotoxic drugs. Serono Symp Publ Raven Press 1989;64:81-7. Ichikawa M, Yoshimura A, Furukawa T, Sumizawa T, Akiyama S. Modulators of the multidrug-transporter, P-glycoprotein, exist in the human plasma. Biochem Biophys Res Commun 1990 Jan 15;166(1):74-80. Ichikawa M, Yoshimura A, Furukawa T, Sumizawa T, Nakazima Y, Akiyama SI. Glycosylation of P-glycoprotein in a multidrug-resistant KB cell line and in the human tissues. Biochim Biophys Acta 1991;1073(2):309-15. LaQuaglia MP, Kopp EB, Spengler BA, Meyers MB, Biedler JL. Altered state of transformation and/or differentiation in multidrug-resistant human neuroblastoma cells [abstract]. Proc Annu Meet Am Assoc Cancer Res 1989;30:A1704. LaQuaglia MP, Kopp EB, Spengler BA, Meyers MB, Biedler JL. Multidrug resistance in human neuroblastoma cells. J Pediatr Surg 1991 Sep; 26(9):1107-12. Mehta BM, Rosa E, Fissekis JD, Bading JR, Biedler JL, Larson SM. In-vivo identification of tumor multidrug resistance with tritium-3-colchicine. J Nucl Med 1992 Jul;33(7):1373-7. Meyers MB, Rittmann-Grauer L, O'Brien JP, Safa AR. Characterization of monoclonal antibodies recognizing a m-r 180000 p-glycoprotein differential expression of the m-r 180000 and m-r 170000 p-glycoproteins in multidrug-resistant human tumor cells. Cancer Res 1989;49(12):3209-14. Meyers MB, Rittmann-Grauer L, O'Brien JP, Safa AR, Cordon-Cardo C, Biedler JL. The 180-KD resistance-related membrane protein recognized by monoclonal antibodies raised against vincristine-resistant human neuroblastoma cells is a P- glycoprotein [abstract]. Proc Annu Meet Am Assoc Cancer Res 1989;30:A2008. Molecular diagnostics of human cancer. Cancer Cells 1989;7:1-414. Murakami T, Ohmori H, Katoh T, Abe T, Higashi K. Cadmium causes increases of N-myc and multidrug-resistance gene mRNA in neuroblastoma cells. Sangyo Ika Daigaku Zasshi 1991 Dec 1;13(4): 271-8. Nabors MW, Griffin CA, Zehnbauer BA, Hruban RH, Phillips PC, Grossman SA, Brem H, Colvin OM. Multidrug resistance gene (MDR1) expression in human brain tumors. J Neurosurg 1991 Dec; 75(6):941-6. Nabors MW, Griffin CA, Zehnbauer BA, Kaufmann SH, Grossman SA, Zhao XL, Brem H, Long DM, Chu YW, Phillips PC, et al. MDR1 expression in human brain tumors [abstract]. Proc Annu Meet Am Assoc Cancer Res 1990;31:A2102. Nakagawara A, Kadomatsu K, Sato S, Kohno K, Takano H, Akazawa K, Nose Y, Kuwano M. Inverse correlation between expression of multidrug resistance gene and N-myc oncogene in human neuroblastomas. Cancer Res 1990 May 15;50(10): 3043-7. O'Brien JP, Spengler BA, Rittmann-Grauer L, Bertino JR, Biedler JL. Collateral sensitivity of human multidrug-resistant cells to verapamil is potentiated by monoclonal antibody HYB-241 recognizing P-glycoprotein [abstract]. Proc Annu Meet Am Assoc Cancer Res 1989;30:A2114. Pastan I, Willingham MC, Gottesman MM. Multidrug resistance. Paper presented at: 6th NCI-EORTC Symposium on New Drugs in Cancer Therapy; 1989 Mar 7-10; Amsterdam. Pileri SA, Sabattini E, Falini B, Tazzari PL, Gherlinzoni F, Michieli MG, Damiani D, Zucchini L, Gobbi M, Tsuruo T, et al. Immunohistochemical detection of the multidrug transport protein P170 in human normal tissues and malignant lymphomas. Histopathology 1991 Aug; 19(2):131-40. Rittmann-Grauer LS, Yong MA, Sanders V, Mackensen DG. Reversal of Vinca alkaloid resistance by anti-P-glycoprotein monoclonal antibody HYB-241 in a human tumor xenograft. Cancer Res 1992 Apr 1; 52(7):1810-6. Schluesener HJ. Multidrug transport in human glioblastoma cells is inhibited by transforming growth factors type beta 1, beta 2, and beta 1.2. J Neurosci Res 1991 Feb;28(2):310-4. Schluesener HJ. Transforming growth factors type beta inhibit multidrug transport in rat astrocyte cell lines. Autoimmunity 1991;9(3):269-75. Schluesener HJ, Meyermann R. Spontaneous multidrug transport in human glioma cells is regulated by transforming growth factors type beta. Acta Neuropathol (Berl) 1991;81(6):641-8. Tebbi CK, Chervinsky D, Baker RM. Modulation of drug resistance in homoharringtonine-resistant C-1300 neuroblastoma cells with cyclosporine A and dipyridamole. J Cell Physiol 1991 Sep;148(3): 464-71. Tebbi CK, Yaeger E, Chervinsky D, Chen Y, Baker R. Dipyrimidole (DPM) is highly effective in reversing multidrug resistance of C1300 neuroblastoma [abstract]. Proc Annu Meet Am Assoc Cancer Res 1990;31:A2096. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC. Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein p170 evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J Histochem Cytochem 1989;37(2):159-64. Tishler DM, Raffel C. Development of multidrug resistance in a primitive neuroectodermal tumor cell line. J Neurosurg 1992 Mar;76(3):502-6. Tishler DM, Weinberg KI, Sender LS, Nolta JA, Raffel C. Multidrug resistance gene expression in pediatric primitive neuroectodermal tumors of the central nervous system. J Neurosurg 1992 Mar; 76(3):507-12. -Breast neoplasms Adams DJ, Knick VC. MDR and non-MDR forms of cellular resistance to 5'-nor-anhydrovinblastine (navelbine) [abstract]. Proc Annu Meet Am Assoc Cancer Res 1992;33:A2760. Aftab DT, Hait WN. Multiple forms of protein kinase C in multidrug resistant MCF-7 human breast cancer cells [abstract]. Proc Annu Meet Am Assoc Cancer Res 1988;29:A1428. Ahmad S, Trepel J, Glazer RI. Protein kinase C isoform-specific mediation of multidrug resistance (MDR) in MDR1-expressing MCF-7 cells [abstract]. Proc Annu Meet Am Assoc Cancer Res 1992;33:A2722. Ahn CH, Fine RL, Anderson WB. Possible involvement of protein- kinase C in the modulation of multidrug resistance [abstract]. Proc Annu Meet Am Assoc Cancer Res 1988;29:A1182. Akman S, Forrest G, Chu FF, Esworthy RS, Stetzler J, Doroshow J. Antioxidant enzyme gene expression in multidrug-resistant MCF-7 breast cancer cells (MCF-7/ADR) [abstract]. Proc Annu Meet Am Assoc Cancer Res 1989;30:A1973. Arredondo M, Guimaraes M, Tsangaris T, Slocum H, Rustum YM. P- glycoprotein content of aneuploid and diploid populations of human breast carcinoma [abstract]. Proc Annu Meet Am Soc Clin Oncol 1992;11:A212. Assaraf YG, Molina A, Schimke RT. Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype. J Natl Cancer Inst 1989 Feb 15;81(4): 290-4. Baird WM, Ferin M, Morgan S, Averbuch SD, Ivy SP, Cowan KH, Myers CE. Metabolism of benzo(a)pyrene (BaP) in the human breast adenocarcinoma cell line MCF-7 and an adriamycin resistant subline Adr(R)MDF-7 [abstract]. Proc Annu Meet Am Assoc Cancer Res 1988;29:A486. Bates SE, Denicoff AM, Cowan K, Tucker E, Begley M, Goldspiel B, Myers C, Fojo T. A study of MDR-1 expression and pharmacologic reversal in human breast cancer [abstract]. Proc Annu Meet Am Soc Clin Oncol 1991;10:A148. Batist G, Schecter R, Woo A, Greene D, Lehnert S. Glutathione depletion in human and in rat multi-drug resistant breast cancer cell lines. Biochem Pharmacol 1991 Feb 15;41(4):631-5. Battifora H. Specificity of immunohistochemical expression of P-glycoprotein [letter]. Hum Pathol 1991 May;22(5):506-7. Benchekroun MM, Schott B, Bennis S, Montaudon D, Robert J. Doxorubicin-induced lipid peroxidation (DILP) and glutathione peroxidase (GPx) activity in multidrug-resistant (MDR) cell lines [abstract]. Proc Annu Meet Am Assoc Cancer Res 1991;32: A2208. Berry JM, Brophy NA, Smith SD, Bergstrom SK, Scudder SA, Roninson IB, Sikic BI. Increased expression of the multidrug resistance gene MDR1 in human cancers [abstract]. Proc Annu Meet Am Soc Clin Oncol 1988;7:A193. Botti G, De Matteis A, Chiappetta G, D'Aiuto G, Esposito G, Picone A. Mammary carcinoma. A multiparametric (MDR-P- glycoprotein expression, regional node status, tumor cells kinetics and receptor status) and immunohistochemical study. J Nucl Med Allied Sci 1990 Oct-Dec;34(4 Suppl): 221-3. Brown R, Keith N, Stallard S, Kaye SB. Expression of mdr1 and gst-pi in breast tumors: correlations with chemoresponsiveness in vitro [abstract]. Proc Annu Meet Am Assoc Cancer Res 1989;30:A2054. Broxterman HJ, Schuurhuis GJ, Lankelma J, Baak JP, Pinedo HM. Towards functional screening for multidrug resistant cells in human malignancies. Pezcoller Found Symp 1990;1:309-29. Chin JE, Soffir R, Noonan KE, Choi K, Roninson IB. Structure and expression of the human mdr p-glycoprotein gene family. Mol Cell Biol 1989; 9(9):3808-20. Cohen D, Piekarz RL, Hsu SI, DePinho RA, Carrasco N, Horwitz SB. Structural and functional analysis of the mouse mdr1b gene promoter. J Biol Chem 1991 Feb 5;266(4):2239-44. Coon JS, Koukoulis G, Roninson I, Weinstein RS. Expression of mdr-1 gene product in benign and malignant breast [abstract]. Lab Invest 1989; 60(1):19A. Cordon-Cardo C, O'Brien JP, Boccia J, Casals D, Bertino JR, Melamed MR. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 1990 Sep;38(9):1277-87. Cordon-Cardo C, O'Brien JP, Casals D, Boccia J, Bertino JR. Immunoanatomic and immunopathologic expression of the multidrug resistance gene product. Cancer Cells 1989; 7:87-93. Critchfield JW, Welsh CJ, Phang JM, Yeh GC. Flavonoids modulate drug accumulation in HCT-15 cells and drug-resistant MCF-7 cells: P-glycoprotein as a possible target [abstract]. Proc Annu Meet Am Assoc Cancer Res 1992;33:A793. Cuvier C, Roblot-Treupel L, Millot JM, Couvreur P, Manfait M, Poupon MF. Doxorubicin, loaded on nanospheres, bypasses multidrug resistance and is detectable as bound to nuclear DNA by microspectrofluorometry. Paper presented at: Symposium on Mechanisms of Drug and Radiation Resistance of Tumor Cells; 1989 Jun 28-30; Villejuif, France. Dalton WS. Mechanisms of drug resistance in breast cancer. Semin Oncol 1990 Aug;17(4 Suppl 7): 37-9. Dalton WS, Grogan TM. Does P-glycoprotein predict response to chemotherapy and if so is there a reliable way to detect it? J Natl Cancer Inst 1991; 83(2):80-1. Degregorio MW, Ford JM, Benz CC, Wiebe VJ. Toremifene pharmacologic and pharmacokinetic basis of reversing multidrug resistance. J Clin Oncol 1989;7(9):1359-64. Dorr RT, Alberts DS, Sami SM, Remers WA. Consistent cytotoxic activity in multidrug resistant tumors for azonafide, a new anthracene analog of amonafide [abstract]. Proc Annu Meet Am Assoc Cancer Res 1991;32:408. Dorr RT, Liddil JD, Von Hoff DD, Soble M, Osborne CK. Antitumor activity and murine pharmacokinetics of parenteral acronycine. Cancer Res 1989;49(2):340-4. Erlichman C, Bjarnason G, Bunting P, DeAngelis C, Kerr I, Maki E, Moore M, Rahemtulla C, Thiessen J, Walker S. Cyclosporin A (CyA) modulation of doxorubicin (D): a pharmacokinetic/ pharmacodynamic trial [abstract]. Proc Annu Meet Am Soc Clin Oncol 1991;10:A314. Salmon SE, Grogan T, Meltzer PS, Dalton WS. Relevance of multidrug resistance to neoadjuvant therapy of cancer. Paper presented at: 2nd International Congress on Neo- Adjuvant Chemotherapy; 1988 Feb 19-21; Paris. Fairchild CR, Cowan KH. Keynote address: Multidrug resistance: a pleiotropic response to cytotoxic drugs. Int J Radiat Oncol Biol Phys 1991 Feb;20(2):361-7. Fairchild CR, Ivy SP, Kao Shan CS, Whang Peng J, Rosen N, Israel MA, Melera PW, Cowan KH, Goldsmith ME. Isolation of amplified and overexpressed DNA sequences from Adriamycin resistant human breast cancer cells. Cancer Res 1987;47(19):5141-8. Fairchild CR, Moscow JA, Ivy SP, Vickers PJ, Cowan KH. An inducible expression vector containing a P-glycoprotein cDNA isolated from adriamycin-resistant MCF-7 cells [abstract]. Proc Annu Meet Am Assoc Cancer Res 1988;29:A1248. Fairchild CR, Moscow JA, O'Brien EE, Cowan KH. Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase-pi. Mol Pharmacol 1990 Jun;37(6):801-9. Fine RL, Carmichael J, Cowan KH, Chabner BA, Patel J. Phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. In: Woolley PV III, Tew KD, editors. Mechanisms of drug resistance in neoplastic cells; 1986 Oct 15-16; Washington, DC. San Diego (CA): Academic Press, Inc.; 1988. p. 87-96. (Bristol-Myers cancer symposia; 9). Fine RL, Patel J, Carmichael J, Chabner BA. Multidrug resistance in human cancer cells: changes in protein phosphorylation and protein kinase. In: Zenser TV, Coe RM, editors. Cancer and aging: progress in research and treatment. New York: Springer Publishing; 1989. p. 158-70. Fine RL, Patel J, Chabner BA. Phorbol esters induce multidrug resistance in human breast cancer cells. Proc Natl Acad Sci U S A 1988;85(2):582-6. Ford JM, Bruggemann EP, Pastan I, Gottesman MM, Hait WN. Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines. Cancer Res 1990 Mar 15;50(6):1748-56. Ford JM, Hait WN. Further characterization of the thioxanthene class of multidrug resistance antagonists [abstract]. Proc Annu Meet Am Assoc Cancer Res 1989;30:570. Ford JM, Prozialeck WC, Hait WN. Identification of active pharmaceuticals against multi-drug resistance through structure activity relationships of calmodulin antagonists [abstract]. Proc Annu Meet Am Assoc Cancer Res 1988;29:313. Ford JM, Prozialeck WC, Hait WN. Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance. Mol Pharmacol 1989;35(1):105-15. Ford JM, Yang JM, Hait WN. Effect of buthionine sulfoximine on toxicity of verapamil and doxorubicin to multidrug resistant cells and to mice. Cancer Res 1991;51(1):67-72. Fuqua SAW, Fitzgerald SD, Fatette NF, Mcguire WL. Expression of mdr-1 in breast cancer [abstract]. Breast Cancer Res Treat 1989;14(1):173. Gewirtz DA, Grant S, Woods KE. Modulation of adriamycin sensitivity in multidrug-resistant MCF-7 breast tumor cells by tomoxifen [abstract]. Proc Annu Meet Am Assoc Cancer Res 1992;33:A2898. Giai M, Biglia N, Sismondi P. Chemoresistance in breast tumors. Eur J Gynaecol Oncol 1991;12(5): 359-73. Goldstein L, Galski H, Fojo A, Willingham M, Green A, Crist W, Gottesman M, Pastan I. Expression of a multidrug- resistance gene in human tumors [abstract]. Proc Annu Meet Am Assoc Cancer Res 1988;29:A1184. Goldstein L, Galski H, Fojo A, Willingham M, Lai SL, Gazdar A, Pirker R, Green A, Crist W, et al. Expression of a multidrug resistance gene in human cancers. J Natl Cancer Inst 1989;81(2):116-24. Gottesman MM, Goldstein LJ, Pastan I. Expression of the multidrug-resistance (MDR1) gene in breast cancer and other cancers. Paper presented at: Biennial International Breast Cancer Research Conference; 1989 Mar 5-9; Tel Aviv University, Tel Aviv. Gottesman MM, Pastan I. A membrane protein that transports natural product cytotoxic drugs. Serono Symp Publ Raven Press 1989;64:81-7. Grandi M, Ballinari D, Capolongo L, Pastori A, Ripamonti M, Suarato A, Spreafico F. [New anthracyclines and multidrug resistance]. Haematologica 1991 Jun;76 Suppl 3:181-3. 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