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$Title{trimethobenzamide}
$Subject{Tebamide G W T-Gen Goldline Tigan Beecham Antiemetic antinauseant
trimethobenzamide nausea vomiting vomiting center brain}
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Tigan*0337001.scf}

Copyright (C) 1993 Publications International, Ltd.


trimethobenzamide
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BRAND NAMES (Manufacturers)

     Tebamide (G & W)
     T-Gen (Goldline)
     Tigan (Beecham)
     trimethobenzamide (various manufacturers)

TYPE OF DRUG

     Antiemetic (antinauseant)

INGREDIENT

     trimethobenzamide

DOSAGE FORMS

     Capsules (100 mg and 250 mg)
     Suppositories (100 mg and 200 mg)

STORAGE

     Trimethobenzamide should be stored at room temperature in a tightly
closed container.

USES

     This drug is used to control nausea and vomiting.  It is thought to act
directly on the vomiting center in the brain.

TREATMENT

     Trimethobenzamide capsules can be taken with a full glass of water.
     The suppository form of this medication should be inserted into the
rectum (if the suppository is too soft to insert, run it under cold water or
put it in the refrigerator for 30 minutes).  To insert it, remove the foil
wrapper, moisten the suppository with a little water, and then lie down on
your left side with your right knee bent.  Push the suppository into your
rectum with your finger.  Remain lying down for a few minutes.  Try to avoid
having a bowel movement for an hour or longer after inserting the suppository
in order to allow time for the drug to be absorbed.
     If you miss a dose of this medication, take the missed dose as soon as
possible, unless it is almost time for the next dose.  In that case, do not
take the missed dose at all; return to your regular dosing schedule.  Do not
double the dose.

SIDE EFFECTS

     Minor.

     Diarrhea, dizziness, drowsiness, headache, or muscle cramps.  These side
effects should disappear as your body adjusts to the medication.
     If you feel dizzy or light-headed, sit or lie down for a while; get up
slowly from a sitting or reclining position, and be careful on stairs.

     Major.

     Tell your doctor about any side effects that are persistent or
particularly bothersome.  IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
back pain, blurred vision, convulsions, depression, disorientation, mouth
sores, rash, tremors, unusual bleeding or bruising, unusual hand or face
movements, or yellowing of the eyes or skin.

INTERACTIONS

     Concurrent use of trimethobenzamide with central nervous system
depressants (drugs that slow the activity of the brain and spinal cord), such
as alcohol, antihistamines, barbiturates, benzodiazepine tranquilizers, muscle
relaxants, narcotics, pain medications, phenothiazine tranquilizers, and
sleeping medications, or with tricyclic antidepressants can cause extreme
drowsiness.
     BE SURE TO TELL YOUR DOCTOR about any medications you are currently
taking, especially those listed above.

WARNINGS

     * Tell your doctor about unusual or allergic reactions you have had to
any medications, especially to trimethobenzamide (or to benzocaine or other
local anesthetics if you are using the suppository form).
     * Be sure to tell your doctor if you now have or if you have ever had
acute fever, dehydration, electrolyte imbalance, intestinal infection, or
viral infections.
     * If this drug makes you dizzy or drowsy, do not take part in any
activity that requires alertness, such as driving a car or operating
potentially dangerous machinery.
     * Be sure to tell your doctor if you are pregnant.  Safe use in pregnancy
has not been established.  Extensive studies in pregnant women have not been
conducted.  Also, tell your doctor if you are breast-feeding an infant.  It is
not known whether trimethobenzamide passes into breast milk.

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The material contained here is "FOR INFORMATION ONLY" and should not replace
the counsel and advice of your personal physician.  Promptly consulting your
doctor is the best path to a quick and successful resolution of any medical
problem.