$Unique_ID{BRK03289}
$Pretitle{}
$Title{phenylpropanolamine and guaifenesin combination}
$Subject{Banex-LA Lu Chem Dura-Vent Dura Entex Norwich-Eaton Guaipax
Vitarine Nolex LA Carnrick Rymed-TR Edwards Tega D&E Ortega Adrenergic
decongestant expectorant phenylpropanolamine guaifenesin coughing congestion
colds sinusitis inflammation sinuses sore throat bronchitis asthma
constricting narrowing blood vessels nasal passages swelling congestion
bronchi}
$Volume{}
$Log{
Entex L.A.*0328901.scf}

Copyright (C) 1993 Publications International, Ltd.


phenylpropanolamine and guaifenesin combination
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BRAND NAMES (Manufacturers)

     Banex-LA (Lu Chem)
     Dura-Vent (Dura)
     Entex L.A. (Norwich-Eaton)
     Guaipax (Vitarine)
     Nolex LA (Carnrick)
     Rymed-TR (Edwards)
     Tega D&E (Ortega)

TYPE OF DRUG

     Adrenergic (decongestant) and expectorant

INGREDIENTs

     phenylpropanolamine and guaifenesin

DOSAGE FORM

     Sustained-release tablets (75 mg phenylpropanolamine and 400 mg or 600 mg
guaifenesin)

STORAGE

     Phenylpropanolamine and guaifenesin combination tablets and capsules
should be stored at room temperature in tightly closed containers.

USES

     This drug combination is used to relieve the coughing and congestion
associated with colds, sinusitis (inflammation of the sinuses), sore throat,
bronchitis, and asthma.
     Phenylpropanolamine belongs to a group of drugs known as adrenergic
agents (decongestants).  They act by constricting (narrowing) blood vessels in
the nasal passages, thereby reducing swelling and congestion.  Guaifenesin is
an expectorant, a drug that loosens bronchial secretions.

TREATMENT

     In order to avoid stomach upset, you can take phenylpropanolamine and
guaifenesin combination with food or with a full glass of milk or water
(unless your doctor directs you to do otherwise).
     These sustained-release tablets should be swallowed whole.  Breaking,
chewing, or crushing them destroys their sustained-release activity and may
increase side effects.
     If you miss a dose of this medication, take the missed dose as soon as
possible, unless it is almost time for your next dose.  In that case, do not
take the missed dose at all; just return to your regular dosing schedule.  Do
not double the next dose.

SIDE EFFECTS

     Minor.

     Insomnia, nervousness, or restlessness.  These side effects should
disappear as your body adjusts to the medication.
     In order to help you avoid difficulty in falling asleep, take the last
dose of this medication several hours before bedtime.

     Major.

     Tell your doctor about any side effects that are persistent or
particularly bothersome.  IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
fainting, headaches, nosebleeds, or palpitations.

INTERACTIONS

     This drug interacts with several other medications:
     1. Monoamine oxidase (MAO) inhibitors (isocarboxazid, pargyline,
phenelzine, or tranylcypromine can increase the side effects of this
medication.  At least 14 days should separate the use of this drug and the use
of an MAO inhibitor.
     2. The blood-pressure-lowering effects of guanethidine may be decreased
by this medication.
     3. The side effects of the decongestant component of this medication can
be increased by digoxin or by over-the-counter (nonprescription) allergy,
asthma, cough, cold, diet, or sinus preparations.
     BE SURE TO TELL YOUR DOCTOR about any medications you are currently
taking, especially any listed above.

WARNINGS

     * Tell your doctor about unusual or allergic reactions you have had to
any medications, especially to guaifenesin or phenylpropanolamine or to other
adrenergic agents (such as albuterol, amphetamines, ephedrine, epinephrine,
isoproterenol, metaproterenol, norepinephrine, pseudoephedrine, and
terbutaline).
     * Tell your doctor if you now have or if you have ever had diabetes
mellitus, glaucoma, heart or blood vessel disease, high blood pressure,
enlarged prostate, or thyroid disease.
     * While you are taking this drug, drink at least eight glasses of water a
day to loosen bronchial secretions.
     * Be sure to tell your doctor if you are pregnant or if you are
breast-feeding an infant.

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The material contained here is "FOR INFORMATION ONLY" and should not replace
the counsel and advice of your personal physician.  Promptly consulting your
doctor is the best path to a quick and successful resolution of any medical
problem.